
The Billion Dollar Molecule
One Company's Quest for the Perfect Drug
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Narrado por:
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Stephen Bowlby
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De:
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Barry Werth
Acerca de esta escucha
Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research.
Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing - atom by atom - both a new life-saving immunosuppressant drug and a drug to combat the virus that causes AIDS.
You will be hooked from start to finish, as you go from the labs, where obsessive, fiercely competitive scientists struggle for a breakthrough, to Wall Street, where the wheeling and dealing takes on a life of its own, as Boger courts investors and finally decides to take Vertex public. Here is a fascinating, no-holds-barred account of the business of science that includes an updated epilogue about the most recent developments in the quest for a drug to cure AIDS.
©1994 Barry Werth; Introduction copyright 2014 by Barry Werth (P)2021 TantorLos oyentes también disfrutaron...
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Eye opening introduction to biomedical R&D
- De Amazon Customer en 09-18-18
De: Richard Harris
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The Demon Under The Microscope
- De: Thomas Hager
- Narrado por: Stephen Hoye
- Duración: 12 h y 14 m
- Versión completa
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The Nazis discovered it. The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic medication. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine.
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Great Book!!!!!
- De Amazon Customer en 05-21-08
De: Thomas Hager
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101 Theory Drive
- A Neuroscientist's Quest for Memory
- De: Terry McDermott
- Narrado por: Stephen Hoye
- Duración: 8 h y 55 m
- Versión completa
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It's not fiction: Gary Lynch is the real thing, the epitome of the rebel scientist - malnourished, contentious, inspiring, explosive, remarkably ambitious, consistently brilliant. He is one of the foremost figures of contemporary neuroscience, and his decades-long quest to understand the inner workings of the brain's memory machine has begun to pay off.
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Pretty Dang Funny
- De Will en 05-14-10
De: Terry McDermott
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A Shot to Save the World
- The Inside Story of the Life-or-Death Race for a COVID-19 Vaccine
- De: Gregory Zuckerman
- Narrado por: Jack Armstrong
- Duración: 12 h y 6 m
- Versión completa
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Few were ready when a mysterious respiratory illness emerged in Wuhan, China, in January 2020. Politicians, government officials, business leaders, and public-health professionals were unprepared for the most devastating pandemic in a century. Many of the world’s biggest drug and vaccine makers were slow to react or couldn’t muster an effective response. It was up to a small group of unlikely and untested scientists and executives to save civilization.
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Wow! Do not miss this one.
- De Jacob en 11-18-21
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Headstrong
- 52 Women Who Changed Science-and the World
- De: Rachel Swaby
- Narrado por: Lauren Fortgang
- Duración: 7 h y 1 m
- Versión completa
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In 2013, the New York Times published an obituary for Yvonne Brill. It began: “She made a mean beef stroganoff, followed her husband from job to job, and took eight years off from work to raise three children.” It wasn’t until the second paragraph that readers discovered why the Times had devoted several hundred words to her life: Brill was a brilliant rocket scientist who invented a propulsion system to keep communications satellites in orbit, and had recently been awarded the National Medal of Technology and Innovation.
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Role models for young women
- De mtsuda90 en 06-25-16
De: Rachel Swaby
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The Idea Factory
- Bell Labs and the Great Age of American Innovation
- De: Jon Gertner
- Narrado por: Chris Sorensen
- Duración: 17 h y 28 m
- Versión completa
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In The Idea Factory, New York Times Magazine writer Jon Gertner reveals how Bell Labs served as an incubator for scientific innovation from the 1920s through the1980s. In its heyday, Bell Labs boasted nearly 15,000 employees, 1200 of whom held PhDs and 13 of whom won Nobel Prizes. Thriving in a work environment that embraced new ideas, Bell Labs scientists introduced concepts that still propel many of today’s most exciting technologies.
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Great story -- horrible pauses
- De Rodney en 01-29-13
De: Jon Gertner
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Sellout
- How Washington Gave Away America's Technological Soul, and One Man's Fight to Bring It Home
- De: Victoria Bruce
- Narrado por: Tom Parks
- Duración: 10 h y 44 m
- Versión completa
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American technological prowess used to be unrivaled. But because of globalization, and with the blessing of the US government, once proprietary materials, components, and technologies are increasingly commercialized outside the United States. Nowhere is this more dangerous than in China's monopoly of rare earth elements - materials that are essential for nearly all modern consumer goods, gadgets, and weapons systems.
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Uncovering unsung heroes of modern America
- De Ben DeNardo en 08-24-17
De: Victoria Bruce
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No Better Time
- The Brief, Remarkable Life of Danny Lewin, the Genius Who Transformed the Internet
- De: Molly Knight Raskin
- Narrado por: Christine Marshall
- Duración: 6 h y 22 m
- Versión completa
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No Better Time tells of a young, driven mathematical genius who wrote a set of algorithms that would create a faster, better Internet. It's the story of a beautiful friendship between a loud, irreverent student and his soft-spoken MIT professor, of a husband and father who spent years struggling to make ends meet only to become a billionaire almost overnight with the success of Akamai Technologies, the Internet content delivery network he cofounded with his mentor.
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An Overlooked Hero of 9-11
- De Jean en 05-27-16
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Big Science
- Ernest Lawrence and the Invention That Launched the Military-Industrial Complex
- De: Michael Hiltzik
- Narrado por: Bob Saouer
- Duración: 14 h y 48 m
- Versión completa
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Since the 1930s, the scale of scientific endeavors has grown exponentially. The birth of Big Science can be traced to Berkeley, California, nearly nine decades ago, when a resourceful young scientist pondered his new invention and declared, "I'm going to be famous!" Ernest Orlando Lawrence's cyclotron would revolutionize nuclear physics, but that was only the beginning of its impact.This is the incredible story of how one invention changed the world and of the man principally responsible for it all. Michael Hiltzik tells the riveting full story here for the first time.
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An informative and thought-provoking book
- De Jean en 08-23-15
De: Michael Hiltzik
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The Chaos Imperative
- How Chance and Disruption Increase Innovation, Effectiveness, and Success
- De: Ori Brafman, Judah Pollack
- Narrado por: Drew Birdseye
- Duración: 4 h y 28 m
- Versión completa
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Ori Brafman and management consultant Judah Pollack dramatically demonstrate how even the best and most efficient organizations - from Fortune 500 companies to today's US Army - can become more innovative by allowing a little unstructured space and "contained chaos" into their planning and decision-making. Through their consulting work, they realized that while structure and hierarchy are essential both in large corporations and small groups, too much of either can stifle creativity.
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a must read!!
- De Kelly Pavich en 05-26-19
De: Ori Brafman, y otros
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The Birth of the Pill
- How Four Crusaders Reinvented Sex and Launched a Revolution
- De: Jonathan Eig
- Narrado por: Gayle Hendrix
- Duración: 12 h y 26 m
- Versión completa
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We know it simply as "the pill", yet its genesis was anything but simple. Jonathan Eig's masterful narrative revolves around four principal characters: the fiery feminist Margaret Sanger, who was a champion of birth control in her campaign for the rights of women but neglected her own children in pursuit of free love; the beautiful Katharine McCormick, who owed her fortune to her wealthy husband, the son of the founder of International Harvester and a schizophrenic.
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Overall Excellent Read
- De Rachel en 04-02-22
De: Jonathan Eig
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Seeing What Others Don't
- The Remarkable Ways We Gain Insights
- De: Gary Klein
- Narrado por: Christopher Lane
- Duración: 9 h
- Versión completa
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Insights—like Darwin's understanding of the way evolution actually works, and Watson and Crick's breakthrough discoveries about the structure of DNA-can change the world. We also need insights into the everyday things that frustrate and confuse us so that we can more effectively solve problems and get things done. Yet we know very little about when, why, or how insights are formed—or what blocks them. In Seeing What Others Don't, renowned cognitive psychologist Gary Klein unravels the mystery.
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Not enough actionable ideas
- De Blair en 02-24-15
De: Gary Klein
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Genentech
- The Beginnings of Biotech
- De: Sally Smith Hughes
- Narrado por: Suzie Althens
- Duración: 7 h y 12 m
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In the fall of 1980, Genentech, Inc., a little-known California genetic engineering company, became the overnight darling of Wall Street, raising over $38 million in its initial public stock offering. Lacking marketed products or substantial profit, the firm nonetheless saw its share price escalate from $35 to $89 in the first few minutes of trading. Coming at a time of economic recession and declining technological competitiveness in the United States, the event ignited a period of speculative frenzy over biotechnology.
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Shallow and lifeless
- De LTS en 11-26-23
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The Antidote
- Inside the World of New Pharma
- De: Barry Werth
- Narrado por: Sean Pratt
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In 1989, the charismatic Joshua Boger left Merck, then America's most admired business, to found a drug company that would challenge industry giants and transform health care. Barry Werth described the company's tumultuous early days during the AIDS crisis in The Billion-Dollar Molecule, a celebrated classic of science and business journalism. Now he returns to tell a riveting story of Vertex's bold endurance and eventual success.
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For me this was not interesting
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The Drug Hunters
- The Improbable Quest to Discover New Medicines
- De: Donald R. Kirsch PhD, Ogi Ogas PhD
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The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity - by chewing, brewing, and snorting - some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the 5,000-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze Age medicine, a worm-killing birch fungus, knotted to his leggings.
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Aargh!
- De Curmud the prof en 05-20-17
De: Donald R. Kirsch PhD, y otros
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For Blood and Money
- Billionaires, Biotech, and the Quest for a Blockbuster Drug
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- Narrado por: Rob Shapiro
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For Blood and Money tells the little-known story of how an upstart biotechnology company created a one-in-a-million cancer drug and how the core team—denied their share of the profits—went and did it again. In this epic saga of money and science, veteran financial journalist Nathan Vardi explains how the invention of two of the biggest cancer drugs in history became (for their backers) two of the greatest Wall Street bets of all time.
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Must-read for biotech enthusiasts and scientists
- De Anonymous User en 03-16-23
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Ten Drugs
- How Plants, Powders, and Pills Have Shaped the History of Medicine
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Beginning with opium, the “joy plant,” which has been used for 10,000 years, Thomas Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.
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Engrossing to physicians & lay persons alike
- De C. White en 03-08-19
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From Breakthrough to Blockbuster
- The Business of Biotechnology
- De: Donald L. Drakeman, Lisa N. Drakeman, Nektarios Oraiopoulos
- Narrado por: Chris Andrew Ciulla
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Beginning in the 1970s, several scientific breakthroughs promised to transform the creation of new medicines. As investors sought to capitalize on these Nobel Prize-winning discoveries, the biotech industry grew to thousands of small companies around the world. Each sought to emulate what the major pharmaceutical companies had been doing for a century or more, but without the advantages of scale, scope, experience, and massive resources. From Breakthrough to Blockbuster focuses on both the companies themselves and the broader biotech ecosystem that supports them.
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Wonderful book!
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De: Donald L. Drakeman, y otros
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Genentech
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In the fall of 1980, Genentech, Inc., a little-known California genetic engineering company, became the overnight darling of Wall Street, raising over $38 million in its initial public stock offering. Lacking marketed products or substantial profit, the firm nonetheless saw its share price escalate from $35 to $89 in the first few minutes of trading. Coming at a time of economic recession and declining technological competitiveness in the United States, the event ignited a period of speculative frenzy over biotechnology.
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Shallow and lifeless
- De LTS en 11-26-23
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The Antidote
- Inside the World of New Pharma
- De: Barry Werth
- Narrado por: Sean Pratt
- Duración: 16 h y 27 m
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In 1989, the charismatic Joshua Boger left Merck, then America's most admired business, to found a drug company that would challenge industry giants and transform health care. Barry Werth described the company's tumultuous early days during the AIDS crisis in The Billion-Dollar Molecule, a celebrated classic of science and business journalism. Now he returns to tell a riveting story of Vertex's bold endurance and eventual success.
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For me this was not interesting
- De Yan en 06-26-17
De: Barry Werth
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The Drug Hunters
- The Improbable Quest to Discover New Medicines
- De: Donald R. Kirsch PhD, Ogi Ogas PhD
- Narrado por: James Foster
- Duración: 7 h y 35 m
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The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity - by chewing, brewing, and snorting - some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the 5,000-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze Age medicine, a worm-killing birch fungus, knotted to his leggings.
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Aargh!
- De Curmud the prof en 05-20-17
De: Donald R. Kirsch PhD, y otros
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For Blood and Money
- Billionaires, Biotech, and the Quest for a Blockbuster Drug
- De: Nathan Vardi
- Narrado por: Rob Shapiro
- Duración: 8 h y 33 m
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Historia
For Blood and Money tells the little-known story of how an upstart biotechnology company created a one-in-a-million cancer drug and how the core team—denied their share of the profits—went and did it again. In this epic saga of money and science, veteran financial journalist Nathan Vardi explains how the invention of two of the biggest cancer drugs in history became (for their backers) two of the greatest Wall Street bets of all time.
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Must-read for biotech enthusiasts and scientists
- De Anonymous User en 03-16-23
De: Nathan Vardi
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Ten Drugs
- How Plants, Powders, and Pills Have Shaped the History of Medicine
- De: Thomas Hager
- Narrado por: Angelo Di Loreto
- Duración: 8 h y 39 m
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Beginning with opium, the “joy plant,” which has been used for 10,000 years, Thomas Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.
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Engrossing to physicians & lay persons alike
- De C. White en 03-08-19
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From Breakthrough to Blockbuster
- The Business of Biotechnology
- De: Donald L. Drakeman, Lisa N. Drakeman, Nektarios Oraiopoulos
- Narrado por: Chris Andrew Ciulla
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Beginning in the 1970s, several scientific breakthroughs promised to transform the creation of new medicines. As investors sought to capitalize on these Nobel Prize-winning discoveries, the biotech industry grew to thousands of small companies around the world. Each sought to emulate what the major pharmaceutical companies had been doing for a century or more, but without the advantages of scale, scope, experience, and massive resources. From Breakthrough to Blockbuster focuses on both the companies themselves and the broader biotech ecosystem that supports them.
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Wonderful book!
- De Momo Abbasi en 04-28-24
De: Donald L. Drakeman, y otros
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Pharma
- Greed, Lies, and the Poisoning of America
- De: Gerald Posner
- Narrado por: Jacques Roy
- Duración: 22 h y 55 m
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Pharmaceutical breakthroughs such as antibiotics and vaccines rank among some of the greatest advancements in human history. Yet, exorbitant prices for life-saving drugs, safety recalls affecting tens of millions of Americans, and soaring rates of addiction and overdose on prescription opioids have caused many to lose faith in drug companies. Now, Americans are demanding a national reckoning with a monolithic industry.
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Great book, but with some issues
- De Irina en 06-12-20
De: Gerald Posner
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Bottle of Lies
- The Inside Story of the Generic Drug Boom
- De: Katherine Eban
- Narrado por: Katherine Eban
- Duración: 14 h y 26 m
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General
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From an award-winning Fortune reporter, an explosive narrative investigation of the generic drug boom that reveals the life-threatening dangers posed by globalization - The Jungle for pharmaceuticals.
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overbearing self-righteous indignation
- De VB en 01-13-20
De: Katherine Eban
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Regenesis
- How Synthetic Biology Will Reinvent Nature and Ourselves
- De: George M. Church, Ed Regis
- Narrado por: Peter Lerman
- Duración: 10 h y 47 m
- Versión completa
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General
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Narración:
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Historia
In Regenesis, George Church and science writer Ed Regis explore the possibilities of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies - far from the out-of-control nightmare depicted in science fiction - have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span.
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Brilliant! But please update!
- De Nick en 01-28-21
De: George M. Church, y otros
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The Myth of Artificial Intelligence
- Why Computers Can’t Think the Way We Do
- De: Erik J. Larson
- Narrado por: Perry Daniels
- Duración: 10 h y 9 m
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General
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Narración:
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Historia
Futurists insist that AI will soon eclipse the capacities of the most gifted human mind. What hope do we have against superintelligent machines? But we aren't really on the path to developing intelligent machines. In fact, we don't even know where that path might be. Erik Larson takes us on a tour of the landscape of AI to show how far we are from superintelligence and what it would take to get there.
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dead wrong after 2 years
- De K. Lyon en 07-11-23
De: Erik J. Larson
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The Song of the Cell
- An Exploration of Medicine and the New Human
- De: Siddhartha Mukherjee
- Narrado por: Dennis Boutsikaris
- Duración: 16 h y 3 m
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General
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Historia
From the author of The Emperor of All Maladies, winner of the Pulitzer Prize, and The Gene, a #1 New York Times bestseller, comes his most spectacular book yet, an exploration of medicine and our radical new ability to manipulate cells. Rich with Mukherjee’s revelatory and exhilarating stories of scientists, doctors, and the patients whose lives may be saved by their work, The Song of the Cell is the third book in this extraordinary writer’s exploration of what it means to be human.
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Beyond Words Wonderful
- De Lynn en 11-27-22
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Human Errors
- A Panorama of Our Glitches, from Pointless Bones to Broken Genes
- De: Nathan H. Lents
- Narrado por: L.J. Ganser
- Duración: 7 h y 54 m
- Versión completa
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General
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Historia
We humans like to think of ourselves as highly evolved creatures. But if we are supposedly evolution's greatest creation, why do we have such bad knees? Why do we catch head colds so often - 200 times more often than a dog does? How come our wrists have so many useless bones? And are we really supposed to swallow and breathe through the same narrow tube? Surely there's been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last.
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From Pointless Bones to Broken Genes to...Aliens?
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De: Nathan H. Lents
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Deep Medicine
- How Artificial Intelligence Can Make Healthcare Human Again
- De: Eric Topol
- Narrado por: Graham Winton
- Duración: 11 h y 6 m
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Medicine has become inhuman, to disastrous effect. The doctor-patient relationship - the heart of medicine - is broken: doctors are too distracted and overwhelmed to truly connect with their patients, and medical errors and misdiagnoses abound. In Deep Medicine, leading physician Eric Topol reveals how artificial intelligence can help. AI has the potential to transform everything doctors do, from notetaking and medical scans to diagnosis and treatment, greatly cutting down the cost of medicine and reducing human mortality.
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a must book for all doctors and patients.
- De adva onn en 04-21-19
De: Eric Topol
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Superconvergence
- How the Genetics, Biotech, and AI Revolutions Will Transform our Lives, Work, and World
- De: Jamie Metzl
- Narrado por: James Anderson Foster, Jamie Metzl
- Duración: 15 h y 44 m
- Versión completa
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General
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Leading futurist and OneShared.World founder Jamie Metzl explores how genome sequencing, gene editing, artificial intelligence, and other technologies are not only changing our lives, but catalyzing each other in radical and accelerating ways. These technologies have the potential to improve our health, feed billions of people, supercharge our economies, and store essential information for millions of years, but can also—if we are not careful—do immeasurable harm.
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Great Book Somewhat Spoiled by Self-Promotion
- De Jack E. Koepke en 06-22-24
De: Jamie Metzl
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Sickening
- How Big Pharma Broke American Health Care and How We Can Repair It
- De: John Abramson
- Narrado por: Kevin Stillwell
- Duración: 9 h y 17 m
- Versión completa
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General
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Narración:
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Historia
The United States spends an excess $1.5 trillion annually on health care compared to other wealthy countries—yet the amount of time that Americans live in good health ranks a lowly 68th in the world. At the heart of the problem is Big Pharma, which funds most clinical trials and therefore controls the research agenda, withholds the real data from those trials as corporate secrets, and shapes most of the information relied upon by health care professionals.
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Great info, but I’m confused…
- De Iread en 04-04-22
De: John Abramson
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The Demon Under The Microscope
- De: Thomas Hager
- Narrado por: Stephen Hoye
- Duración: 12 h y 14 m
- Versión completa
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General
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Narración:
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Historia
The Nazis discovered it. The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic medication. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine.
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Great Book!!!!!
- De Amazon Customer en 05-21-08
De: Thomas Hager
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Information Architecture
- For the Web and Beyond
- De: Louis Rosenfeld, Peter Morville, Jorge Arango
- Narrado por: Theodore O'Brien
- Duración: 11 h
- Versión completa
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General
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Narración:
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Historia
Information architecture (IA) is far more challenging - and necessary - than ever. To guide you through this broad ecosystem, this popular guide - now in its fourth edition - provides essential concepts, methods, and techniques for digital design that have withstood the test of time. UX designers, product managers, developers, and anyone involved in digital design will learn how to create semantic structures that will help people engage with your message.
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Well organized and right to the points
- De Coco en 06-08-23
De: Louis Rosenfeld, y otros
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The Catalyst
- RNA and the Quest to Unlock Life's Deepest Secrets
- De: Thomas R. Cech
- Narrado por: Joshua Saxon
- Duración: 6 h y 54 m
- Versión completa
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General
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Historia
A gripping journey of discovery, The Catalyst moves from the early experiments that first hinted at RNA's spectacular powers, to Cech's own paradigm-shifting finding that it can catalyze cellular reactions, to the cutting-edge biotechnologies poised to reshape our health.
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Captivating
- De Auinash Kalsotra en 09-16-24
De: Thomas R. Cech
Lo que los oyentes dicen sobre The Billion Dollar Molecule
Calificaciones medias de los clientesReseñas - Selecciona las pestañas a continuación para cambiar el origen de las reseñas.
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- Alexa
- 05-05-23
Book is interesting but narrator is not
Nothing against the author but it was really hard for me to stay engaged with the narrator. I would find myself spacing out consistently which would detract from the story because of the performance. Because of this I returned the book
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