The Billion Dollar Molecule
One Company's Quest for the Perfect Drug
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The Billion Dollar Molecule
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Narrado por:
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Stephen Bowlby
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De:
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Barry Werth
Acerca de esta escucha
Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research.
Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing - atom by atom - both a new life-saving immunosuppressant drug and a drug to combat the virus that causes AIDS.
You will be hooked from start to finish, as you go from the labs, where obsessive, fiercely competitive scientists struggle for a breakthrough, to Wall Street, where the wheeling and dealing takes on a life of its own, as Boger courts investors and finally decides to take Vertex public. Here is a fascinating, no-holds-barred account of the business of science that includes an updated epilogue about the most recent developments in the quest for a drug to cure AIDS.
©1994 Barry Werth; Introduction copyright 2014 by Barry Werth (P)2021 TantorLos oyentes también disfrutaron...
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Historia4 out of 5 stars 68
In 1989, the charismatic Joshua Boger left Merck, then America's most admired business, to found a drug company that would challenge industry giants and transform health care. Barry Werth described the company's tumultuous early days during the AIDS crisis in The Billion-Dollar Molecule, a celebrated classic of science and business journalism. Now he returns to tell a riveting story of Vertex's bold endurance and eventual success.
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2 out of 5 stars
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For me this was not interesting
- De Yan en 06-26-17
De: Barry Werth
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The Drug Hunters
- The Improbable Quest to Discover New Medicines
- De: Donald R. Kirsch PhD, Ogi Ogas PhD
- Narrado por: James Foster
- Duración: 7 h y 35 m
- Versión completa
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General4.5 out of 5 stars 1,175
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Narración:4.5 out of 5 stars 1,065
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Historia4.5 out of 5 stars 1,064
The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity - by chewing, brewing, and snorting - some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the 5,000-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze Age medicine, a worm-killing birch fungus, knotted to his leggings.
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3 out of 5 stars
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Aargh!
- De Curmud the prof en 05-20-17
De: Donald R. Kirsch PhD, y otros
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For Blood and Money
- Billionaires, Biotech, and the Quest for a Blockbuster Drug
- De: Nathan Vardi
- Narrado por: Rob Shapiro
- Duración: 8 h y 33 m
- Versión completa
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General4.5 out of 5 stars 241
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Narración:4.5 out of 5 stars 201
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Historia4.5 out of 5 stars 200
For Blood and Money tells the little-known story of how an upstart biotechnology company created a one-in-a-million cancer drug and how the core team—denied their share of the profits—went and did it again. In this epic saga of money and science, veteran financial journalist Nathan Vardi explains how the invention of two of the biggest cancer drugs in history became (for their backers) two of the greatest Wall Street bets of all time.
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5 out of 5 stars
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Must-read for biotech enthusiasts and scientists
- De Anonymous User en 03-16-23
De: Nathan Vardi
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From Breakthrough to Blockbuster
- The Business of Biotechnology
- De: Donald L. Drakeman, Lisa N. Drakeman, Nektarios Oraiopoulos
- Narrado por: Chris Andrew Ciulla
- Duración: 7 h y 1 m
- Versión completa
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General4.5 out of 5 stars 10
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Narración:4.5 out of 5 stars 7
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Historia4.5 out of 5 stars 7
Beginning in the 1970s, several scientific breakthroughs promised to transform the creation of new medicines. As investors sought to capitalize on these Nobel Prize-winning discoveries, the biotech industry grew to thousands of small companies around the world. Each sought to emulate what the major pharmaceutical companies had been doing for a century or more, but without the advantages of scale, scope, experience, and massive resources. From Breakthrough to Blockbuster focuses on both the companies themselves and the broader biotech ecosystem that supports them.
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2 out of 5 stars
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Nothing to learn for pharma professionals
- De Anonymous User en 09-12-23
De: Donald L. Drakeman, y otros
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Ten Drugs
- How Plants, Powders, and Pills Have Shaped the History of Medicine
- De: Thomas Hager
- Narrado por: Angelo Di Loreto
- Duración: 8 h y 39 m
- Versión completa
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General4.5 out of 5 stars 4,929
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Narración:4.5 out of 5 stars 4,265
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Historia4.5 out of 5 stars 4,247
Beginning with opium, the “joy plant,” which has been used for 10,000 years, Thomas Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.
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4 out of 5 stars
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Engrossing to physicians & lay persons alike
- De C. White en 03-08-19
De: Thomas Hager
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Pharma
- Greed, Lies, and the Poisoning of America
- De: Gerald Posner
- Narrado por: Jacques Roy
- Duración: 22 h y 55 m
- Versión completa
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General4.5 out of 5 stars 199
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Narración:5 out of 5 stars 169
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Historia4.5 out of 5 stars 167
Pharmaceutical breakthroughs such as antibiotics and vaccines rank among some of the greatest advancements in human history. Yet, exorbitant prices for life-saving drugs, safety recalls affecting tens of millions of Americans, and soaring rates of addiction and overdose on prescription opioids have caused many to lose faith in drug companies. Now, Americans are demanding a national reckoning with a monolithic industry.
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5 out of 5 stars
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Great book, but with some issues
- De Irina en 06-12-20
De: Gerald Posner
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Bottle of Lies
- The Inside Story of the Generic Drug Boom
- De: Katherine Eban
- Narrado por: Katherine Eban
- Duración: 14 h y 26 m
- Versión completa
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General5 out of 5 stars 1,084
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Narración:4.5 out of 5 stars 950
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Historia5 out of 5 stars 948
From an award-winning Fortune reporter, an explosive narrative investigation of the generic drug boom that reveals the life-threatening dangers posed by globalization - The Jungle for pharmaceuticals.
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1 out of 5 stars
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overbearing self-righteous indignation
- De VB en 01-13-20
De: Katherine Eban
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Human Errors
- A Panorama of Our Glitches, from Pointless Bones to Broken Genes
- De: Nathan H. Lents
- Narrado por: L.J. Ganser
- Duración: 7 h y 54 m
- Versión completa
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General4.5 out of 5 stars 2,281
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Narración:4.5 out of 5 stars 2,007
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Historia4.5 out of 5 stars 2,002
We humans like to think of ourselves as highly evolved creatures. But if we are supposedly evolution's greatest creation, why do we have such bad knees? Why do we catch head colds so often - 200 times more often than a dog does? How come our wrists have so many useless bones? And are we really supposed to swallow and breathe through the same narrow tube? Surely there's been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last.
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4 out of 5 stars
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From Pointless Bones to Broken Genes to...Aliens?
- De Katy.LED en 12-04-18
De: Nathan H. Lents
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An Epidemic of Absence
- A New Way of Understanding Allergies and Autoimmune Diseases
- De: Moises Velasquez-Manoff
- Narrado por: Chris Sorensen
- Duración: 17 h y 6 m
- Versión completa
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General4.5 out of 5 stars 55
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Narración:4.5 out of 5 stars 48
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Historia4.5 out of 5 stars 49
An Epidemic of Absence asks what will happen in developing countries, which, as they become more affluent, have already seen an uptick in allergic disease: Will India end up more allergic than Europe? Velasquez-Manoff also details a controversial underground movement that has coalesced around the treatment of immune-mediated disorders with parasites. Against much of his better judgment, he joins these do-it-yourselfers and reports his surprising results.
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5 out of 5 stars
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The point of view from a Veterinarian immunologist
- De rtgymnast en 11-03-17
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The Theory That Would Not Die
- How Bayes' Rule Cracked the Enigma Code, Hunted Down Russian Submarines, and Emerged Triumphant from Two Centuries of Controversy
- De: Sharon Bertsch McGrayne
- Narrado por: Laural Merlington
- Duración: 11 h y 51 m
- Versión completa
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General4.5 out of 5 stars 488
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Narración:4 out of 5 stars 410
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Historia4.5 out of 5 stars 410
Bayes' rule appears to be a straightforward, one-line theorem: by updating our initial beliefs with objective new information, we get a new and improved belief. To its adherents, it is an elegant statement about learning from experience. To its opponents, it is subjectivity run amok. Sharon Bertsch McGrayne here explores this controversial theorem and the human obsessions surrounding it.
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4 out of 5 stars
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Who is the intended audience?
- De Billy en 07-21-14
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Liquid Rules
- The Delightful and Dangerous Substances That Flow Through Our Lives
- De: Mark Miodownik
- Narrado por: Michael Page
- Duración: 7 h y 16 m
- Versión completa
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General4.5 out of 5 stars 2,251
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Narración:4.5 out of 5 stars 1,948
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Historia4.5 out of 5 stars 1,950
We all know that without water we couldn't survive, and that sometimes a cup of coffee or a glass of wine feels just as vital. But do we really understand how much we rely on liquids, or the destructive power they hold? Set over the course of a flight from London to San Francisco, Liquid Rules offers listeners a fascinating tour of these formless substances, told through the language of molecules, droplets, heartbeats, and ocean waves.
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5 out of 5 stars
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Interesting book!
- De Wayne en 08-04-19
De: Mark Miodownik
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The Epigenetics Revolution
- How Modern Biology Is Rewriting Our Understanding of Genetics, Disease, and Inheritance
- De: Nessa Carey
- Narrado por: Donna Postel
- Duración: 11 h y 16 m
- Versión completa
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General4.5 out of 5 stars 475
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Narración:4.5 out of 5 stars 409
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Historia4.5 out of 5 stars 406
Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the 20-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics.
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3 out of 5 stars
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Begins Accessible, Then Becomes Too Technical
- De wbiro en 07-26-17
De: Nessa Carey
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Ageless
- The New Science of Getting Older Without Getting Old
- De: Andrew Steele
- Narrado por: Andrew Steele
- Duración: 9 h y 47 m
- Versión completa
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General4.5 out of 5 stars 209
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Narración:4.5 out of 5 stars 176
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Historia4.5 out of 5 stars 171
Aging - not cancer, not heart disease - is the underlying cause of most human death and suffering. The same cascade of biological changes that renders us wrinkled and gray also opens the door to dementia and disease. We work furiously to conquer each individual disease, but we never think to ask: Is aging itself necessary? Nature tells us it is not: There are tortoises and salamanders who are spry into old age and whose risk of dying is the same no matter how old they are.
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3 out of 5 stars
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General overview of aging and aging research
- De RealWoman8 en 03-31-21
De: Andrew Steele
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The Song of the Cell
- An Exploration of Medicine and the New Human
- De: Siddhartha Mukherjee
- Narrado por: Dennis Boutsikaris
- Duración: 16 h y 3 m
- Versión completa
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General4.5 out of 5 stars 878
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Narración:4.5 out of 5 stars 743
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Historia4.5 out of 5 stars 737
From the author of The Emperor of All Maladies, winner of the Pulitzer Prize, and The Gene, a #1 New York Times bestseller, comes his most spectacular book yet, an exploration of medicine and our radical new ability to manipulate cells. Rich with Mukherjee’s revelatory and exhilarating stories of scientists, doctors, and the patients whose lives may be saved by their work, The Song of the Cell is the third book in this extraordinary writer’s exploration of what it means to be human.
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5 out of 5 stars
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Beyond Words Wonderful
- De Lynn en 11-27-22
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The Catalyst
- RNA and the Quest to Unlock Life's Deepest Secrets
- De: Thomas R. Cech
- Narrado por: Joshua Saxon
- Duración: 6 h y 54 m
- Versión completa
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General4 out of 5 stars 18
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Narración:3.5 out of 5 stars 16
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Historia4 out of 5 stars 16
A gripping journey of discovery, The Catalyst moves from the early experiments that first hinted at RNA's spectacular powers, to Cech's own paradigm-shifting finding that it can catalyze cellular reactions, to the cutting-edge biotechnologies poised to reshape our health.
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5 out of 5 stars
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Captivating
- De Auinash Kalsotra en 09-16-24
De: Thomas R. Cech
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The Myth of Artificial Intelligence
- Why Computers Can’t Think the Way We Do
- De: Erik J. Larson
- Narrado por: Perry Daniels
- Duración: 10 h y 9 m
- Versión completa
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General4.5 out of 5 stars 121
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Narración:4.5 out of 5 stars 106
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Historia4.5 out of 5 stars 104
Futurists insist that AI will soon eclipse the capacities of the most gifted human mind. What hope do we have against superintelligent machines? But we aren't really on the path to developing intelligent machines. In fact, we don't even know where that path might be. Erik Larson takes us on a tour of the landscape of AI to show how far we are from superintelligence and what it would take to get there.
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1 out of 5 stars
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dead wrong after 2 years
- De K. Lyon en 07-11-23
De: Erik J. Larson
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Deep Medicine
- How Artificial Intelligence Can Make Healthcare Human Again
- De: Eric Topol
- Narrado por: Graham Winton
- Duración: 11 h y 6 m
- Versión completa
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General4.5 out of 5 stars 764
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Narración:4.5 out of 5 stars 646
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Historia4.5 out of 5 stars 642
Medicine has become inhuman, to disastrous effect. The doctor-patient relationship - the heart of medicine - is broken: doctors are too distracted and overwhelmed to truly connect with their patients, and medical errors and misdiagnoses abound. In Deep Medicine, leading physician Eric Topol reveals how artificial intelligence can help. AI has the potential to transform everything doctors do, from notetaking and medical scans to diagnosis and treatment, greatly cutting down the cost of medicine and reducing human mortality.
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5 out of 5 stars
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a must book for all doctors and patients.
- De adva onn en 04-21-19
De: Eric Topol
Lo que los oyentes dicen sobre The Billion Dollar Molecule
Calificaciones medias de los clientesReseñas - Selecciona las pestañas a continuación para cambiar el origen de las reseñas.
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Total4 out of 5 stars
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Ejecución1 out of 5 stars
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Historia4 out of 5 stars
- Alexa
- 05-05-23
Book is interesting but narrator is not
Nothing against the author but it was really hard for me to stay engaged with the narrator. I would find myself spacing out consistently which would detract from the story because of the performance. Because of this I returned the book
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