The Antidote
Inside the World of New Pharma
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The Antidote
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Narrado por:
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Sean Pratt
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De:
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Barry Werth
Acerca de esta escucha
In 1989, the charismatic Joshua Boger left Merck, then America's most admired business, to found a drug company that would challenge industry giants and transform health care. Barry Werth described the company's tumultuous early days during the AIDS crisis in The Billion-Dollar Molecule, a celebrated classic of science and business journalism. Now he returns to tell a riveting story of Vertex's bold endurance and eventual success.
The $325-billion-a-year pharmaceutical business is America's toughest and one of its most profitable. It is riskier and more rigorous at just about every stage than any other business, from the towering biological uncertainties inherent in its mission to treat disease; to the 30-to-1 failure rate in bringing out a successful medicine even after a molecule clears all the hurdles to get to human testing; to the multibillion-dollar cost of ramping up a successful product; to operating in the world's most regulated industry, matched only by nuclear power.
Werth captures the full scope of Vertex's 25-year drive to deliver breakthrough medicines. At a time when America struggles to maintain its innovative edge, The Antidote is a powerful inside look at one of the most intriguing and important business stories of recent decades.
©2014 Barry Werth (P)2014 TantorLos oyentes también disfrutaron...
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Lee Hood did that rarest of things. He enabled scientists to see things they couldn't see before and do things they hadn't dreamed of doing. Scientists can now sequence complete human genomes in a day, setting in motion a revolution that is personalizing medicine. Hood, a son of the American West, was an unlikely candidate to transform biology. But with ferocious drive, he led a team at Caltech that developed the automated DNA sequencer, the tool that paved the way for the Human Genome Project.
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4 out of 5 stars
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A Revealing Biography
- De Jean en 07-27-17
De: Luke Timmerman, y otros
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Mastering the VC Game
- A Venture Capital Insider Reveals How to Get from Start-Up to IPO on Your Terms
- De: Jeffrey Bussgang
- Narrado por: Ramon De Ocampo
- Duración: 7 h y 14 m
- Versión completa
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General4.5 out of 5 stars 166
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Narración:4.5 out of 5 stars 134
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Historia4.5 out of 5 stars 134
Finding the right venture capitalist to back your start-up is a challenge. Even if you manage to get backing, you want your VC to be a partner, not some dictator who will undermine your vision and take control of your life's work. Jeffrey Bussgang is one of a very few people who have played on both sides of this high-stakes game. Now he draws on his unique perspective to offer high-level insights, colorful stories, and practical advice. He reveals how to get noticed, perfect a pitch, and negotiate a partnership that works for everyone.
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5 out of 5 stars
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slow in beginning but gets really good
- De Diana en 04-11-19
De: Jeffrey Bussgang
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Rigor Mortis
- How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions
- De: Richard Harris
- Narrado por: Joe Delafield
- Duración: 5 h y 56 m
- Versión completa
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General4.5 out of 5 stars 116
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Narración:4.5 out of 5 stars 99
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Historia4.5 out of 5 stars 98
American taxpayers spend $30 billion annually funding biomedical research, but over half of these studies can't be replicated due to poor experimental design, improper methods, and sloppy statistics. Bad science doesn't just hold back medical progress, it can sign the equivalent of a death sentence for terminal patients. In Rigor Mortis, Richard Harris explores these urgent issues with vivid anecdotes, personal stories, and interviews with the top biomedical researchers. We need to fix our dysfunctional biomedical system - before it's too late.
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5 out of 5 stars
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Eye opening introduction to biomedical R&D
- De Amazon Customer en 09-18-18
De: Richard Harris
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A Shot to Save the World
- The Inside Story of the Life-or-Death Race for a COVID-19 Vaccine
- De: Gregory Zuckerman
- Narrado por: Jack Armstrong
- Duración: 12 h y 6 m
- Versión completa
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General4.5 out of 5 stars 174
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Narración:4.5 out of 5 stars 147
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Historia4.5 out of 5 stars 146
Few were ready when a mysterious respiratory illness emerged in Wuhan, China, in January 2020. Politicians, government officials, business leaders, and public-health professionals were unprepared for the most devastating pandemic in a century. Many of the world’s biggest drug and vaccine makers were slow to react or couldn’t muster an effective response. It was up to a small group of unlikely and untested scientists and executives to save civilization.
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5 out of 5 stars
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Wow! Do not miss this one.
- De Jacob en 11-18-21
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Where Does It Hurt?
- An Entrepreneur's Guide to Fixing Health Care
- De: Jonathan Bush, Stephen Baker
- Narrado por: Patrick Lawlor
- Duración: 7 h y 21 m
- Versión completa
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General4.5 out of 5 stars 145
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Narración:4.5 out of 5 stars 114
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Historia4.5 out of 5 stars 116
A bold new remedy for the sprawling and wasteful health care industry. In this provocative book, Jonathan Bush, cofounder and CEO of athenahealth, calls for a revolution in health care to give customers more choices, freedom, power, and information, and at far lower prices.
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2 out of 5 stars
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No critical thinking
- De Steve from MD en 07-31-14
De: Jonathan Bush, y otros
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American Icon
- Alan Mulally and the Fight to Save Ford Motor Company
- De: Bryce G. Hoffman
- Narrado por: Pete Larkin
- Duración: 14 h y 45 m
- Versión completa
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General4.5 out of 5 stars 2,278
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Narración:4.5 out of 5 stars 1,985
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Historia4.5 out of 5 stars 1,984
At the end of 2008, Ford Motor Company was just months away from running out of cash. With the auto industry careening toward ruin, Congress offered all three Detroit automakers a bailout. General Motors and Chrysler grabbed the taxpayer lifeline, but Ford decided to save itself. Under the leadership of charismatic CEO Alan Mulally, Ford had already put together a bold plan to unify its divided global operations, transform its lackluster product lineup, and overcome a dysfunctional culture of infighting, backstabbing, and excuses.
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5 out of 5 stars
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The best business book I ever read
- De Michael en 10-07-12
De: Bryce G. Hoffman
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Open
- How Compaq Ended IBM's PC Domination and Helped Invent Modern Computing
- De: Rod Canion
- Narrado por: Paul Boehmer
- Duración: 6 h y 19 m
- Versión completa
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General4.5 out of 5 stars 118
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Narración:4 out of 5 stars 110
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Historia4.5 out of 5 stars 108
Open provides valuable lessons in leadership in times of crisis, management decision-making under the pressure of extraordinary growth, and the power of a unique, pervasive culture. Open tells the incredible story of Compaq’s meteoric rise from humble beginnings to become the PC industry leader in just over a decade. Along the way, Compaq helped change the face of computing while establishing the foundation for today’s world of tablets and smart phones.
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3 out of 5 stars
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Wrong narrator for this book
- De Wick Smith en 07-13-14
De: Rod Canion
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The Firm
- The Story of McKinsey and Its Secret Influence on American Business
- De: Duff McDonald
- Narrado por: Tom Weiner
- Duración: 11 h y 19 m
- Versión completa
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General4.5 out of 5 stars 723
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Narración:4.5 out of 5 stars 606
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Historia4 out of 5 stars 605
A behind-the-scenes, revelatory history of McKinsey & Company, America's most influential and controversial business consulting firm, told by one of the nation's leading financial journalists. In The Firm, Duff McDonald uncovers how these high-powered, high-priced business savants have ushered in waves of structural, financial, and technological shifts. With unrivaled access to company documents and current and former employees, McDonald reveals the inner workings of what just might be the most influential private organization in America.
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3 out of 5 stars
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Warning: Non consultants should avoid
- De R. Jaeger en 11-04-13
De: Duff McDonald
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Overhaul
- An Insider's Account of the Obama Administration's Emergency Rescue of the Auto Industry
- De: Steven Rattner
- Narrado por: Joe Barrett
- Duración: 13 h y 28 m
- Versión completa
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General4.5 out of 5 stars 54
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Narración:4.5 out of 5 stars 43
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Historia4.5 out of 5 stars 43
This first real look inside Team Obama mixes political warfare and big-business shakeups in equal proportions, and comes from a uniquely informed source. Steve Rattner is not just the man brought in by the president to save the auto industry, he is a former New York Times financial reporter who also earned a place among the top tier of Wall Street's most informed investment bankers and corporate experts.
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5 out of 5 stars
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Overhaul - A Memoir
- De Roy en 12-05-10
De: Steven Rattner
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Who Says Elephants Can't Dance?
- Inside IBM's Historic Turnaround
- De: Louis V. Gerstner Jr.
- Narrado por: Edward Herrmann
- Duración: 8 h y 29 m
- Versión completa
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General4.5 out of 5 stars 902
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Narración:4.5 out of 5 stars 566
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Historia4.5 out of 5 stars 563
In 1990, IBM had its most profitable year ever. By 1993, the company was on a watch list for extinction, victimized by its own lumbering size, an insular corporate culture, and the PC era IBM had itself helped invent.
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5 out of 5 stars
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Moderate Start, Picks up FAST!
- De Art H en 02-08-05
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Epic Measures
- One Doctor. Seven Billion Patients.
- De: Jeremy N. Smith
- Narrado por: Patrick Lawlor
- Duración: 10 h y 12 m
- Versión completa
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General4.5 out of 5 stars 62
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Narración:4.5 out of 5 stars 51
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Historia4.5 out of 5 stars 49
Moneyball meets medicine in this remarkable chronicle of one of the greatest scientific quests of our time - the groundbreaking program to answer the most essential question for humanity: How do we live and die? - and the visionary mastermind behind it.
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5 out of 5 stars
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Fabulously insightful read!
- De Dr. Jack E. Fincham en 10-08-15
De: Jeremy N. Smith
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Good for the Money
- My Fight to Pay Back America
- De: Bob Benmosche
- Narrado por: Sean Pratt
- Duración: 9 h y 33 m
- Versión completa
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General4.5 out of 5 stars 70
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Narración:5 out of 5 stars 65
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Historia4.5 out of 5 stars 64
In 2009, at the peak of the financial crisis, AIG - the American insurance behemoth - was sinking fast. It was the peg upon which the nation hung its ire and resentment during the financial crisis: the pinnacle of Wall Street arrogance and greed. When Bob Benmosche climbed aboard as CEO, it was widely assumed that he would go down with his ship. In mere months, he turned things around, pulling AIG from the brink of financial collapse and restoring its profitability.
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4 out of 5 stars
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Worthwhile, informative, and just short of inspiring
- De Preston en 11-17-21
De: Bob Benmosche
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Silent Invasion
- The Untold Story of the Trump Administration, Covid-19, and Preventing the Next Pandemic Before It's Too Late
- De: Deborah Birx
- Narrado por: Kathe Mazur
- Duración: 22 h y 3 m
- Versión completa
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General4.5 out of 5 stars 132
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Narración:4.5 out of 5 stars 114
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Historia4.5 out of 5 stars 115
In late February 2020, Dr. Deborah Birx—a lifelong federal health official who had worked at the CDC, the State Department, and the US Army across multiple presidential administrations—was asked to join the Trump White House Coronavirus Task Force and assist the already faltering federal response to the Covid-19 pandemic. For weeks, she’d been raising the alarm behind the scenes about what she saw happening in public—from the apparent lack of urgency at the White House to the routine downplaying of the risks to Americans.
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5 out of 5 stars
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Great insight into Public Health
- De Ann-Karen Weller en 05-09-22
De: Deborah Birx
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No Better Time
- The Brief, Remarkable Life of Danny Lewin, the Genius Who Transformed the Internet
- De: Molly Knight Raskin
- Narrado por: Christine Marshall
- Duración: 6 h y 22 m
- Versión completa
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General4.5 out of 5 stars 65
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Narración:4.5 out of 5 stars 61
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Historia4.5 out of 5 stars 60
No Better Time tells of a young, driven mathematical genius who wrote a set of algorithms that would create a faster, better Internet. It's the story of a beautiful friendship between a loud, irreverent student and his soft-spoken MIT professor, of a husband and father who spent years struggling to make ends meet only to become a billionaire almost overnight with the success of Akamai Technologies, the Internet content delivery network he cofounded with his mentor.
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4 out of 5 stars
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An Overlooked Hero of 9-11
- De Jean en 05-27-16
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A Bigger Prize
- How We Can Do Better Than the Competition
- De: Margaret Heffernan
- Narrado por: Margaret Heffernan
- Duración: 15 h y 48 m
- Versión completa
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General4.5 out of 5 stars 40
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Narración:4.5 out of 5 stars 31
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Historia4 out of 5 stars 31
From the cranberry bogs of Massachusetts to the classrooms of Singapore and Finland, from tiny start-ups to global engineering firms and beloved American organizations like Ocean Spray, Eileen Fisher, Gore, and Boston Scientific, Heffernan discovers ways of living and working that foster creativity, spark innovation, reinforce our social fabric, and feel so much better than winning.
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5 out of 5 stars
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Margaret Heffernan is brilliant!
- De Eric Willingham en 06-09-16
-
Good to Great
- Why Some Companies Make the Leap...And Others Don't
- De: Jim Collins
- Narrado por: Jim Collins
- Duración: 10 h y 1 m
- Versión completa
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General4.5 out of 5 stars 17,618
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Narración:4.5 out of 5 stars 14,495
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Historia4.5 out of 5 stars 14,399
Built To Last, the defining management study of the 90s, showed how great companies triumph over time and how long-term sustained performance can be engineered into the DNA of an enterprise from the very beginning. But what about companies that are not born with great DNA? How can good companies, mediocre companies, even bad companies achieve enduring greatness?
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3 out of 5 stars
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Good info, over-the-top narration
- De Anaxamaxan en 08-31-10
De: Jim Collins
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Finish Big
- How Great Entrepreneurs Exit Their Companies on Top
- De: Bo Burlingham
- Narrado por: Sean Pratt
- Duración: 10 h y 17 m
- Versión completa
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General4.5 out of 5 stars 158
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Narración:4.5 out of 5 stars 130
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Historia4.5 out of 5 stars 128
When pioneering business journalist and Inc. magazine editor at large Bo Burlingham wrote Small Giants, it became an instant classic for its original take on a common business problem - how to handle the pressure to grow. Now Burlingham is back to tackle an even more common problem - how to exit your company well. Sooner or later, all entrepreneurs leave their businesses and all businesses get sold, given away, or liquidated.
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5 out of 5 stars
-
Begin with the end in mind
- De D. Hartzell en 02-05-15
De: Bo Burlingham
-
Data-ism
- The Revolution Transforming Decision Making, Consumer Behavior, and Almost Everything Else
- De: Steve Lohr
- Narrado por: Steve Lohr
- Duración: 6 h y 33 m
- Versión completa
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General4 out of 5 stars 117
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Narración:4 out of 5 stars 100
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Historia4 out of 5 stars 97
Coal, iron ore, and oil were the key productive assets that fueled the Industrial Revolution. Today data is the vital raw material of the information economy. The explosive abundance of this digital asset, more than doubling every two years, is creating a new world of opportunity and challenge. Data-ism is about this next phase, in which vast, Internet-scale data sets are used for discovery and prediction in virtually every field. It is a journey across this emerging world with people, illuminating narrative examples, and insights.
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4 out of 5 stars
-
More business case than serious analysis
- De Godfried Gubbels en 06-03-15
De: Steve Lohr
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Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research. Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing - atom by atom - both a new life-saving immunosuppressant drug and a drug to combat the virus that causes AIDS.
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The Antidote
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From Pulitzer finalist, MacArthur Fellowship recipient, and bestselling author of Swamplandia! and Vampires in the Lemon Grove Karen Russell comes a gripping dust bowl epic about five characters whose fates become entangled after a storm ravages their small Nebraskan town The Antidote opens on Black Sunday, as a historic dust storm ravages the fictional town of Uz, Nebraska. But Uz is already collapsing—not just under the weight of the Great Depression and the dust bowl drought, but beneath its own violent histories.
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Beginning with opium, the “joy plant,” which has been used for 10,000 years, Thomas Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.
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Beginning in the 1970s, several scientific breakthroughs promised to transform the creation of new medicines. As investors sought to capitalize on these Nobel Prize-winning discoveries, the biotech industry grew to thousands of small companies around the world. Each sought to emulate what the major pharmaceutical companies had been doing for a century or more, but without the advantages of scale, scope, experience, and massive resources. From Breakthrough to Blockbuster focuses on both the companies themselves and the broader biotech ecosystem that supports them.
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Wonderful book!
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Genentech
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In the fall of 1980, Genentech, Inc., a little-known California genetic engineering company, became the overnight darling of Wall Street, raising over $38 million in its initial public stock offering. Lacking marketed products or substantial profit, the firm nonetheless saw its share price escalate from $35 to $89 in the first few minutes of trading. Coming at a time of economic recession and declining technological competitiveness in the United States, the event ignited a period of speculative frenzy over biotechnology.
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2 out of 5 stars
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Shallow and lifeless
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For Blood and Money tells the little-known story of how an upstart biotechnology company created a one-in-a-million cancer drug and how the core team—denied their share of the profits—went and did it again. In this epic saga of money and science, veteran financial journalist Nathan Vardi explains how the invention of two of the biggest cancer drugs in history became (for their backers) two of the greatest Wall Street bets of all time.
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Must-read for biotech enthusiasts and scientists
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Lo que los oyentes dicen sobre The Antidote
Calificaciones medias de los clientesReseñas - Selecciona las pestañas a continuación para cambiar el origen de las reseñas.
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Total5 out of 5 stars
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Ejecución4 out of 5 stars
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Historia5 out of 5 stars
- Michael Bigger
- 10-28-16
Creating Societal Value
Enjoyed listening to the inside stories about the challenges of creating life enhancing products for humanity. A+
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Total5 out of 5 stars
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Ejecución5 out of 5 stars
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Historia5 out of 5 stars
- Paul Gerard
- 06-27-15
Development of elegant new medicine
The author brings us inside the finance and science of the development of an entirely new concept in medicine. Vertex looks at chronic illness at the mechanism and focuses on fixing the problem rather than the symptoms. This is the 21st century in health care.
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Total2 out of 5 stars
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Ejecución4 out of 5 stars
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Historia1 out of 5 stars
- Yan
- 06-26-17
For me this was not interesting
Sorry for the harsh commentary.... It's like someone compiled all of their stock market announcements into a book, flavored with some irrelevant details about the employees... I was hoping to hear some insights about the pharma market. The book started well.
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