The Philadelphia Chromosome
A Mutant Gene and the Quest to Cure Cancer at the Genetic Level
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The Philadelphia Chromosome
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Narrado por:
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Heather Henderson
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De:
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Jessica Wapner
Acerca de esta escucha
Almost daily, headlines announce newly discovered links between cancers and their genetic causes. Science journalist Jessica Wapner vividly relates the backstory behind those headlines, reconstructing the crucial breakthroughs, explaining the science behind them, and giving due to the dozens of researchers, doctors, and patients whose curiosity and determination restored the promise of a future to the more than 50,000 people diagnosed each year with chronic myeloid leukemia (CML). It is an astonishing tale that will provide victims of other cancers and their loved ones realistic hope that cures may yet be found in their lifetimes.
The Philadelphia Chromosome charts the milestones that led to present-day cancer treatment and tells the inspiring story of the dedicated men and women who, working individually and in concert, have sought to plum the mysteries of the human genome in order to conquer those deadly and most feared diseases called cancer.
©2013 Jessica Wapner (P)2013 HighBridge Company.Los oyentes también disfrutaron...
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p53: The Gene That Cracked the Cancer Code reveals the tale of the search for this gene, as well as the excitement of the hunt for new cures - the hype, the lost opportunities, the blind alleys, and the thrilling breakthroughs. As the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms starts to take off at last, p53 is still at the forefront of the game. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.
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5 out of 5 stars
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Excellent story! Unfortunate narration at start
- De Adriana en 12-25-14
De: Sue Armstrong
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Rigor Mortis
- How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions
- De: Richard Harris
- Narrado por: Joe Delafield
- Duración: 5 h y 56 m
- Versión completa
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General4.5 out of 5 stars 116
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Narración:4.5 out of 5 stars 99
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Historia4.5 out of 5 stars 98
American taxpayers spend $30 billion annually funding biomedical research, but over half of these studies can't be replicated due to poor experimental design, improper methods, and sloppy statistics. Bad science doesn't just hold back medical progress, it can sign the equivalent of a death sentence for terminal patients. In Rigor Mortis, Richard Harris explores these urgent issues with vivid anecdotes, personal stories, and interviews with the top biomedical researchers. We need to fix our dysfunctional biomedical system - before it's too late.
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5 out of 5 stars
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Eye opening introduction to biomedical R&D
- De Amazon Customer en 09-18-18
De: Richard Harris
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The Emperor of All Maladies
- A Biography of Cancer
- De: Siddhartha Mukherjee
- Narrado por: Fred Sanders
- Duración: 22 h y 18 m
- Versión completa
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General5 out of 5 stars 4,736
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Narración:5 out of 5 stars 4,145
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Historia5 out of 5 stars 4,123
The Emperor of All Maladies reveals the many faces of an iconic, shape-shifting disease that is the defining plague of our generation. The story of cancer is a story of human ingenuity, resilience, and perseverance but also of hubris, arrogance, paternalism, and misperception, all leveraged against a disease that, just three decades ago, was thought to be easily vanquished in an all-out "war against cancer".
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5 out of 5 stars
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Incredible
- De S.R.E. en 03-02-16
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A Crack in Creation
- Gene Editing and the Unthinkable Power to Control Evolution
- De: Jennifer A. Doudna, Samuel H. Sternberg
- Narrado por: Erin Bennett
- Duración: 9 h y 22 m
- Versión completa
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General4.5 out of 5 stars 1,367
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Narración:4.5 out of 5 stars 1,169
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Historia4.5 out of 5 stars 1,168
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.
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5 out of 5 stars
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In to the abyss we ascend, a scary future
- De Philomath en 06-17-17
De: Jennifer A. Doudna, y otros
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The Compatibility Gene
- How Our Bodies Fight Disease, Attract Others, and Define Our Selves
- De: Daniel M. Davis
- Narrado por: Christopher Grove
- Duración: 7 h y 48 m
- Versión completa
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General4.5 out of 5 stars 53
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Narración:4.5 out of 5 stars 43
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Historia4.5 out of 5 stars 43
Most of the 25,000 genes we possess are the same for all of us. Compatibility genes are those that vary most from person to person and give each of us a unique molecular signature. These genes determine both the extent to which we are susceptible to a vast range of illnesses and the different ways each of us fights disease.
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5 out of 5 stars
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If interested in medicine, got to read
- De Howard Sterling en 06-29-16
De: Daniel M. Davis
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Happy Accidents
- Serendipity in Major Medical Breakthroughs in the Twentieth Century
- De: Morton A. Meyers
- Narrado por: Richard Waterhouse
- Duración: 12 h y 37 m
- Versión completa
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General4.5 out of 5 stars 49
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Narración:4 out of 5 stars 44
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Historia4.5 out of 5 stars 43
Happy Accidents is a fascinating, entertaining, and highly accessible look at the surprising role serendipity has played in some of the most important medical discoveries in the 20th century. What do penicillin, chemotherapy drugs, X-rays, Valium, the Pap smear, and Viagra have in common? They were each discovered accidentally, stumbled upon in the search for something else. In discussing medical breakthroughs, Dr. Morton Meyers makes a cogent, highly engaging argument for a more creative, rather than purely linear, approach to science. And it may just save our lives!
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1 out of 5 stars
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Don't waste your money!
- De Amazon Customer en 03-20-16
De: Morton A. Meyers
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The Language of Life
- DNA and the Revolution in Personalized Medicine
- De: Francis S. Collins
- Narrado por: Greg Itzin
- Duración: 10 h y 45 m
- Versión completa
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General4 out of 5 stars 148
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Narración:4.5 out of 5 stars 99
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Historia4 out of 5 stars 98
A scientific and medical revolution has crept up on us, based on study after study, from hundreds of laboratories around the world. It is no longer just a theoretical shift: every one of us will be touched by it, and many of us already have been. The meaning of disease, our understanding of the human body, and crucial decisions about what we all need to know and what choices we make about our health are at stake. Welcome to the new world of personalized medicine.
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5 out of 5 stars
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The future of medicine
- De Ronald E en 04-12-10
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The Cancer Chronicles
- Unlocking Medicine's Deepest Mystery
- De: George Johnson
- Narrado por: Arthur Morey
- Duración: 8 h y 19 m
- Versión completa
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General4.5 out of 5 stars 63
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Narración:4.5 out of 5 stars 54
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Historia4.5 out of 5 stars 54
When the woman he loved was diagnosed with a metastatic cancer, science writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is a revolution under way - an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease.
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5 out of 5 stars
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A quick read - hard to put down
- De Digital Dilema en 09-06-13
De: George Johnson
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Influenza
- The Hundred-Year Hunt to Cure the 1918 Spanish Flu Pandemic
- De: Dr. Jeremy Brown
- Narrado por: Holter Graham
- Duración: 6 h y 28 m
- Versión completa
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General4.5 out of 5 stars 360
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Narración:4.5 out of 5 stars 309
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Historia4.5 out of 5 stars 307
On the 100th anniversary of the devastating pandemic of 1918, Jeremy Brown, a veteran ER doctor, explores the troubling, terrifying, and complex history of the flu virus, from the origins of the Great Flu that killed millions, to vexing questions such as: are we prepared for the next epidemic, should you get a flu shot, and how close are we to finding a cure?
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5 out of 5 stars
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Important read
- De Kathryn C. en 12-21-18
De: Dr. Jeremy Brown
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Ten Drugs
- How Plants, Powders, and Pills Have Shaped the History of Medicine
- De: Thomas Hager
- Narrado por: Angelo Di Loreto
- Duración: 8 h y 39 m
- Versión completa
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General4.5 out of 5 stars 4,926
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Narración:4.5 out of 5 stars 4,262
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Historia4.5 out of 5 stars 4,244
Beginning with opium, the “joy plant,” which has been used for 10,000 years, Thomas Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.
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4 out of 5 stars
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Engrossing to physicians & lay persons alike
- De C. White en 03-08-19
De: Thomas Hager
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Editing Humanity
- The CRISPR Revolution and the New Era of Genome Editing
- De: Kevin Davies
- Narrado por: Kevin Davies
- Duración: 16 h y 17 m
- Versión completa
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General4.5 out of 5 stars 76
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Narración:4.5 out of 5 stars 65
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Historia4.5 out of 5 stars 65
Engrossing and captivating, Editing Humanity takes listeners inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to edit the DNA of any organism down to the individual building blocks of the genetic code. Davies introduces listeners to arguably the most profound scientific breakthrough of our time. He tracks the scientists on the front lines of its research to the patients whose powerful stories bring the narrative movingly to human scale.
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4 out of 5 stars
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Excellent content, solid execution
- De Samuel Finlayson en 01-25-21
De: Kevin Davies
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The Secret History of the War on Cancer
- De: Devra Davis Ph.D.
- Narrado por: Pam Ward
- Duración: 19 h y 11 m
- Versión completa
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General4.5 out of 5 stars 36
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Narración:4.5 out of 5 stars 23
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Historia4.5 out of 5 stars 24
The War on Cancer was run by leaders of industries that made cancer-causing products and sometimes also profited from drugs and technologies for finding and treating the disease. Filled with compelling personalities and never-before-revealed information, The Secret History of the War on Cancer shows how we began fighting the wrong war, with the wrong weapons, against the wrong enemies, a legacy that persists to this day.
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2 out of 5 stars
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Silly Book
- De Adam Smith en 12-24-14
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The Demon Under The Microscope
- De: Thomas Hager
- Narrado por: Stephen Hoye
- Duración: 12 h y 14 m
- Versión completa
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General4.5 out of 5 stars 3,494
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Narración:4.5 out of 5 stars 2,548
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Historia4.5 out of 5 stars 2,546
The Nazis discovered it. The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic medication. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine.
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5 out of 5 stars
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Great Book!!!!!
- De Amazon Customer en 05-21-08
De: Thomas Hager
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The Antidote
- Inside the World of New Pharma
- De: Barry Werth
- Narrado por: Sean Pratt
- Duración: 16 h y 27 m
- Versión completa
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General4 out of 5 stars 78
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Narración:4 out of 5 stars 67
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Historia4 out of 5 stars 68
In 1989, the charismatic Joshua Boger left Merck, then America's most admired business, to found a drug company that would challenge industry giants and transform health care. Barry Werth described the company's tumultuous early days during the AIDS crisis in The Billion-Dollar Molecule, a celebrated classic of science and business journalism. Now he returns to tell a riveting story of Vertex's bold endurance and eventual success.
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2 out of 5 stars
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For me this was not interesting
- De Yan en 06-26-17
De: Barry Werth
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Plague of Corruption
- Restoring Faith in the Promise of Science
- De: Dr. Judy Mikovits, Kent Heckenlively, Robert F. Kennedy Jr.
- Narrado por: Mariel Hemingway
- Duración: 10 h y 10 m
- Versión completa
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General5 out of 5 stars 814
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Narración:4.5 out of 5 stars 727
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Historia5 out of 5 stars 725
Dr. Judy Mikovits is a modern-day Rosalind Franklin, a brilliant researcher shaking up the old boys' club of science with her groundbreaking discoveries. And like many women who have trespassed into the world of men, she uncovered decades-old secrets that many would prefer to stay buried.
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5 out of 5 stars
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If only most of the public knew these facts
- De David Getoff, CCN en 06-18-20
De: Dr. Judy Mikovits, y otros
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Denialism
- How Irrational Thinking Hinders Scientific Progress, Harms the Planet, and Threatens Our Lives
- De: Michael Specter
- Narrado por: Richard Poe
- Duración: 8 h y 33 m
- Versión completa
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General4 out of 5 stars 150
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Narración:4 out of 5 stars 100
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Historia4 out of 5 stars 99
New Yorker staff writer Michael Specter has twice won the Global Health Council’s Excellence in Media Award, as well as the Science Journalism Award from the American Association for the Advancement of Science. In Denialism, he fervently argues that people are turning away from new technologies and engaging in a kind of magical thinking that is hindering scientific progress.
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5 out of 5 stars
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A compelling read
- De S en 05-17-11
De: Michael Specter
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A Shot to Save the World
- The Inside Story of the Life-or-Death Race for a COVID-19 Vaccine
- De: Gregory Zuckerman
- Narrado por: Jack Armstrong
- Duración: 12 h y 6 m
- Versión completa
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General4.5 out of 5 stars 174
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Narración:4.5 out of 5 stars 147
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Historia4.5 out of 5 stars 146
Few were ready when a mysterious respiratory illness emerged in Wuhan, China, in January 2020. Politicians, government officials, business leaders, and public-health professionals were unprepared for the most devastating pandemic in a century. Many of the world’s biggest drug and vaccine makers were slow to react or couldn’t muster an effective response. It was up to a small group of unlikely and untested scientists and executives to save civilization.
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5 out of 5 stars
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Wow! Do not miss this one.
- De Jacob en 11-18-21
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Missing Microbes
- How the Overuse of Antibiotics Is Fueling Our Modern Plagues
- De: Martin J. Blaser
- Narrado por: Patrick Lawlor
- Duración: 8 h y 43 m
- Versión completa
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General4.5 out of 5 stars 385
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Narración:4.5 out of 5 stars 328
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Historia4.5 out of 5 stars 330
In Missing Microbes, Dr. Martin J. Blaser invites us into the wilds of the human microbiome, where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the health and equilibrium of our body. Now this invisible eden is being irrevocably damaged by some of our most revered medical advances-antibiotics-threatening the extinction of our irreplaceable microbes with terrible health consequences.
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5 out of 5 stars
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Very enlightening and information well supported
- De James en 05-03-15
De: Martin J. Blaser
Lo que los oyentes dicen sobre The Philadelphia Chromosome
Calificaciones medias de los clientesReseñas - Selecciona las pestañas a continuación para cambiar el origen de las reseñas.
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Total5 out of 5 stars
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Ejecución5 out of 5 stars
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Historia5 out of 5 stars
- Ronda
- 03-17-16
Great topic for those in medicine
This book details the research and development and treatment for CML patients with the Philadelphia Chromosome defect. I work with cancer patients so I found the book extremely interesting--not overly technical for the lay person, but technical enough to keep me interested and listening with anticipation.
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esto le resultó útil a 3 personas
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Total4 out of 5 stars
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Ejecución4 out of 5 stars
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Historia5 out of 5 stars
- Michael D. Stone
- 06-27-13
GREAT story.
If you could sum up The Philadelphia Chromosome in three words, what would they be?
Encouraging wonderful story
Who was your favorite character and why?
Dr Brian Druker.... a TRUE modern day HERO!
Have you listened to any of Heather Henderson’s other performances before? How does this one compare?
No
Was there a moment in the book that particularly moved you?
anything that referred to Dr Drukers drive to see this all the way through
Any additional comments?
A REALLY good and important book. Inspirational. Criticism? a tad too repetetive.
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esto le resultó útil a 3 personas