Junk DNA
A Journey Through the Dark Matter of the Genome
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Narrado por:
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Cat Gould
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De:
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Nessa Carey
Acerca de esta escucha
For decades after the identification of the structure of DNA, scientists focused only on genes, the regions of the genome that contain codes for the production of proteins. Other regions that make up 98 percent of the human genome were dismissed as "junk," sequences that serve no purpose. But researchers have recently discovered variations and modulations in this junk DNA that are involved with a number of intractable diseases.
Junk DNA can play vital and unanticipated roles in the control of gene expression, from fine-tuning individual genes to switching off entire chromosomes. These functions have forced scientists to revisit the very meaning of the word "gene" and have engendered a spirited scientific battle over whether or not this genomic "nonsense" is the source of human biological complexity. Drawing on her experience with leading scientific investigators in Europe and North America, Nessa Carey provides a clear and compelling introduction to junk DNA and its critical involvement in phenomena as diverse as genetic diseases, viral infections, sex determination in mammals, and evolution. Nessa Carey's book is an essential resource for navigating the history and controversies of this fast-growing, hotly disputed field.
©2015 Nessa Carey (P)2020 TantorLos oyentes también disfrutaron...
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- Duración: 9 h
- Versión completa
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General4 out of 5 stars 106
-
Narración:4 out of 5 stars 91
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Historia4 out of 5 stars 92
Over a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way.
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3 out of 5 stars
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Great Scientific Writing/ Wrong Narrator
- De Richard en 11-24-15
De: John Parrington
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Human Errors
- A Panorama of Our Glitches, from Pointless Bones to Broken Genes
- De: Nathan H. Lents
- Narrado por: L.J. Ganser
- Duración: 7 h y 54 m
- Versión completa
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General4.5 out of 5 stars 2,278
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Narración:4.5 out of 5 stars 2,004
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Historia4.5 out of 5 stars 1,999
We humans like to think of ourselves as highly evolved creatures. But if we are supposedly evolution's greatest creation, why do we have such bad knees? Why do we catch head colds so often - 200 times more often than a dog does? How come our wrists have so many useless bones? And are we really supposed to swallow and breathe through the same narrow tube? Surely there's been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last.
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4 out of 5 stars
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From Pointless Bones to Broken Genes to...Aliens?
- De Katy.LED en 12-04-18
De: Nathan H. Lents
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Welcome to the Microbiome
- Getting to Know the Trillions of Bacteria and Other Microbes In, On, and Around You
- De: Rob DeSalle, Susan L. Perkins
- Narrado por: Stephen McLaughlin
- Duración: 7 h y 25 m
- Versión completa
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General4.5 out of 5 stars 36
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Narración:4.5 out of 5 stars 35
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Historia4.5 out of 5 stars 34
Suddenly, research findings require a paradigm shift in our view of the microbial world. The Human Microbiome Project at the National Institutes of Health is well under way, and unprecedented scientific technology now allows the censusing of trillions of microbes inside and on our bodies as well as in the places where we live, work, and play. This intriguing, up-to-the-minute book for scientists and nonscientists alike explains what researchers are discovering about the microbe world and what the implications are for modern science and medicine.
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5 out of 5 stars
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I learned so much from this book. I am happy.
- De Jonathan Miller en 09-08-18
De: Rob DeSalle, y otros
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The Language of Life
- DNA and the Revolution in Personalized Medicine
- De: Francis S. Collins
- Narrado por: Greg Itzin
- Duración: 10 h y 45 m
- Versión completa
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General4 out of 5 stars 148
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Narración:4.5 out of 5 stars 99
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Historia4 out of 5 stars 98
A scientific and medical revolution has crept up on us, based on study after study, from hundreds of laboratories around the world. It is no longer just a theoretical shift: every one of us will be touched by it, and many of us already have been. The meaning of disease, our understanding of the human body, and crucial decisions about what we all need to know and what choices we make about our health are at stake. Welcome to the new world of personalized medicine.
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5 out of 5 stars
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The future of medicine
- De Ronald E en 04-12-10
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Evolving Ourselves
- How Unnatural Selection and Nonrandom Mutation are Changing Life on Earth
- De: Juan Enriquez, Steve Gullans
- Narrado por: Rob Shapiro
- Duración: 10 h y 50 m
- Versión completa
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General4.5 out of 5 stars 205
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Narración:4.5 out of 5 stars 179
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Historia4.5 out of 5 stars 182
Why are conditions like autism, asthma, obesity, and allergies exploding at unprecedented rates? Why are we living longer, getting smarter, having far fewer kids? If Darwin were alive today, how would he explain this new world?
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5 out of 5 stars
-
fascinating ideas and science
- De Joel en 07-04-15
De: Juan Enriquez, y otros
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The Compatibility Gene
- How Our Bodies Fight Disease, Attract Others, and Define Our Selves
- De: Daniel M. Davis
- Narrado por: Christopher Grove
- Duración: 7 h y 48 m
- Versión completa
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General4.5 out of 5 stars 53
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Narración:4.5 out of 5 stars 43
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Historia4.5 out of 5 stars 43
Most of the 25,000 genes we possess are the same for all of us. Compatibility genes are those that vary most from person to person and give each of us a unique molecular signature. These genes determine both the extent to which we are susceptible to a vast range of illnesses and the different ways each of us fights disease.
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5 out of 5 stars
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If interested in medicine, got to read
- De Howard Sterling en 06-29-16
De: Daniel M. Davis
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A Crack in Creation
- Gene Editing and the Unthinkable Power to Control Evolution
- De: Jennifer A. Doudna, Samuel H. Sternberg
- Narrado por: Erin Bennett
- Duración: 9 h y 22 m
- Versión completa
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General4.5 out of 5 stars 1,367
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Narración:4.5 out of 5 stars 1,169
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Historia4.5 out of 5 stars 1,168
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.
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5 out of 5 stars
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In to the abyss we ascend, a scary future
- De Philomath en 06-17-17
De: Jennifer A. Doudna, y otros
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Herding Hemingway's Cats
- Understanding How Our Genes Work
- De: Kat Arney
- Narrado por: Kat Arney
- Duración: 8 h y 39 m
- Versión completa
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General4.5 out of 5 stars 53
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Narración:4.5 out of 5 stars 47
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Historia4.5 out of 5 stars 46
The language of genes has become common parlance. We know they make your eyes blue, your hair curly or your nose straight. The media tells us that our genes control the risk of cancer, heart disease, alcoholism or Alzheimer's. The cost of DNA sequencing has plummeted from billions of pounds to a few hundred, and gene-based advances in medicine hold huge promise. So we've all heard of genes, but how do they actually work?
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2 out of 5 stars
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A non-scientists misguided interpretation
- De AraSevera en 05-15-16
De: Kat Arney
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The Gene
- An Intimate History
- De: Siddhartha Mukherjee
- Narrado por: Dennis Boutsikaris
- Duración: 19 h y 22 m
- Versión completa
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General4.5 out of 5 stars 5,913
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Narración:4.5 out of 5 stars 5,185
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Historia4.5 out of 5 stars 5,138
The extraordinary Siddhartha Mukherjee has written a biography of the gene as deft, brilliant, and illuminating as his extraordinarily successful biography of cancer. Weaving science, social history, and personal narrative to tell us the story of one of the most important conceptual breakthroughs of modern times, Mukherjee animates the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.
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5 out of 5 stars
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It's a Wonderful Book
- De JKC en 06-02-16
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The Vital Question
- Energy, Evolution, and the Origins of Complex Life
- De: Nick Lane
- Narrado por: Kevin Pariseau
- Duración: 11 h y 27 m
- Versión completa
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General4.5 out of 5 stars 1,183
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Narración:4.5 out of 5 stars 1,046
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Historia4.5 out of 5 stars 1,035
The Earth teems with life: in its oceans, forests, skies, and cities. Yet there's a black hole at the heart of biology. We do not know why complex life is the way it is, or, for that matter, how life first began. In The Vital Question, award-winning author and biochemist Nick Lane radically reframes evolutionary history, putting forward a solution to conundrums that have puzzled generations of scientists.
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4 out of 5 stars
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Ouch!
- De Mark en 06-24-16
De: Nick Lane
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p53: The Gene That Cracked the Cancer Code
- De: Sue Armstrong
- Narrado por: Elizabeth Jasicki
- Duración: 9 h y 55 m
- Versión completa
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General4.5 out of 5 stars 125
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Narración:4 out of 5 stars 109
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Historia4.5 out of 5 stars 107
p53: The Gene That Cracked the Cancer Code reveals the tale of the search for this gene, as well as the excitement of the hunt for new cures - the hype, the lost opportunities, the blind alleys, and the thrilling breakthroughs. As the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms starts to take off at last, p53 is still at the forefront of the game. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.
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5 out of 5 stars
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Excellent story! Unfortunate narration at start
- De Adriana en 12-25-14
De: Sue Armstrong
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An Epidemic of Absence
- A New Way of Understanding Allergies and Autoimmune Diseases
- De: Moises Velasquez-Manoff
- Narrado por: Chris Sorensen
- Duración: 17 h y 6 m
- Versión completa
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General4.5 out of 5 stars 55
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Narración:4.5 out of 5 stars 48
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Historia4.5 out of 5 stars 49
An Epidemic of Absence asks what will happen in developing countries, which, as they become more affluent, have already seen an uptick in allergic disease: Will India end up more allergic than Europe? Velasquez-Manoff also details a controversial underground movement that has coalesced around the treatment of immune-mediated disorders with parasites. Against much of his better judgment, he joins these do-it-yourselfers and reports his surprising results.
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5 out of 5 stars
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The point of view from a Veterinarian immunologist
- De rtgymnast en 11-03-17
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Missing Microbes
- How the Overuse of Antibiotics Is Fueling Our Modern Plagues
- De: Martin J. Blaser
- Narrado por: Patrick Lawlor
- Duración: 8 h y 43 m
- Versión completa
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General4.5 out of 5 stars 385
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Narración:4.5 out of 5 stars 328
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Historia4.5 out of 5 stars 330
In Missing Microbes, Dr. Martin J. Blaser invites us into the wilds of the human microbiome, where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the health and equilibrium of our body. Now this invisible eden is being irrevocably damaged by some of our most revered medical advances-antibiotics-threatening the extinction of our irreplaceable microbes with terrible health consequences.
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5 out of 5 stars
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Very enlightening and information well supported
- De James en 05-03-15
De: Martin J. Blaser
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Sicker, Fatter, Poorer
- The Urgent Threat of Hormone-Disrupting Chemicals on Our Health and Future . . . and What We Can Do About It
- De: Leonardo Trasande MD MPP
- Narrado por: Leonardo Trasande MD MPP
- Duración: 6 h y 44 m
- Versión completa
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General4.5 out of 5 stars 45
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Narración:4.5 out of 5 stars 38
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Historia4.5 out of 5 stars 38
Lurking in our homes, hiding in our offices, and polluting the air we breathe is something sinister. Something we’ve turned a blind eye to for far too long. Dr. Leonardo Trasande, a pediatrician, professor, and world-renowned researcher, tells the story of how our everyday surroundings are making us sicker, fatter, and poorer. Through a blend of narrative, scientific detective work, and concrete information about the connections between chemicals and disease, he reveals what we can do to protect ourselves and our families in the short-term, and how we can help bring the change we deserve.
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5 out of 5 stars
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The Must Read Book of 2019 is here early on Audio!
- De Ryan S en 12-21-18
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The Cancer Chronicles
- Unlocking Medicine's Deepest Mystery
- De: George Johnson
- Narrado por: Arthur Morey
- Duración: 8 h y 19 m
- Versión completa
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General4.5 out of 5 stars 63
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Narración:4.5 out of 5 stars 54
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Historia4.5 out of 5 stars 54
When the woman he loved was diagnosed with a metastatic cancer, science writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is a revolution under way - an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease.
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5 out of 5 stars
-
A quick read - hard to put down
- De Digital Dilema en 09-06-13
De: George Johnson
-
A Series of Fortunate Events
- Chance and the Making of the Planet, Life, and You
- De: Sean B. Carroll
- Narrado por: Sean B. Carroll
- Duración: 4 h y 48 m
- Versión completa
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General4.5 out of 5 stars 131
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Narración:5 out of 5 stars 111
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Historia4.5 out of 5 stars 109
Why is the world the way it is? How did we get here? Does everything happen for a reason, or are some things left to chance? Philosophers and theologians have pondered these questions for millennia, but startling scientific discoveries over the past half century are revealing that we live in a world driven by chance. A Series of Fortunate Events tells the story of the awesome power of chance and how it is the surprising source of all the beauty and diversity in the living world.
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4 out of 5 stars
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We are for a short time.
- De Anonymous User en 10-14-20
De: Sean B. Carroll
-
10% Human
- How Your Body's Microbes Hold the Key to Health and Happiness
- De: Alanna Collen
- Narrado por: Cat Gould
- Duración: 12 h y 45 m
- Versión completa
-
General4.5 out of 5 stars 98
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Narración:4.5 out of 5 stars 83
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Historia4.5 out of 5 stars 83
You are just 10% human. For every one of the cells that make up the vessel that you call your body, there are nine impostor cells hitching a ride. You are not just flesh and blood, muscle and bone, brain and skin, but also bacteria and fungi. Over your lifetime, you will carry the equivalent weight of five African elephants in microbes. You are not an individual but a colony. Until recently, we had thought our microbes hardly mattered, but science is revealing a different story, one in which microbes run our bodies and becoming a healthy human is impossible without them.
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5 out of 5 stars
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Must read for anyone that wants to be healthy
- De T. Kalinowski en 06-05-21
De: Alanna Collen
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Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the 20-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics.
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Just 45 years ago, the age of gene modification was born. Researchers could create glow-in-the-dark mice, farmyard animals producing drugs in their milk, and vitamin-enhanced rice that could prevent half a million people going blind every year. But now GM is rapidly being supplanted by a new system called CRISPR or "gene editing". Using this approach, scientists can manipulate the genes of almost any organism with a degree of precision, ease and speed that we could only dream of ten years ago.
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James D. Watson, the Nobel laureate whose pioneering work helped unlock the mystery of DNA's structure, charts the greatest scientific journey of our time, from the discovery of the double helix to today's controversies to what the future may hold. Updated to include new findings in gene editing, epigenetics, and agricultural chemistry as well as two entirely new chapters on personal genomics and cancer research. This is the most comprehensive and authoritative exploration of DNA's impact on our society and our world.
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What happened to the ancient Egyptians? When their civilization fell, did the Egyptian people disappear? Or do their descendants exist to this day? What about the ancient Persians? Romans? Mayans? For years, the answers to these questions have been hidden. But no more. Nathaniel T. Jeanson, a Harvard graduate with a PhD in cell and developmental biology, has discovered a DNA-based, generation by generation family tree for global humanity. This tree uncovers the origin and fate of these ancient peoples—and connects them to peoples alive today.
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Bending Science to Support Biblical View
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Mitochondria and the Future of Medicine
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In Mitochondria and the Future of Medicine, naturopathic doctor Lee Know tells the epic story of mitochondria - the widely misunderstood and often-overlooked powerhouses of our cells. The legendary saga began over two billion years ago, when one bacterium entered another without being digested, which would evolve to create the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that have been responsible for this life-giving energy.
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Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the 20-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics.
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Just 45 years ago, the age of gene modification was born. Researchers could create glow-in-the-dark mice, farmyard animals producing drugs in their milk, and vitamin-enhanced rice that could prevent half a million people going blind every year. But now GM is rapidly being supplanted by a new system called CRISPR or "gene editing". Using this approach, scientists can manipulate the genes of almost any organism with a degree of precision, ease and speed that we could only dream of ten years ago.
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- De: James D. Watson, Andrew Berry, Kevin Davies
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General4.5 out of 5 stars 117
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Narración:4.5 out of 5 stars 98
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Historia4.5 out of 5 stars 98
James D. Watson, the Nobel laureate whose pioneering work helped unlock the mystery of DNA's structure, charts the greatest scientific journey of our time, from the discovery of the double helix to today's controversies to what the future may hold. Updated to include new findings in gene editing, epigenetics, and agricultural chemistry as well as two entirely new chapters on personal genomics and cancer research. This is the most comprehensive and authoritative exploration of DNA's impact on our society and our world.
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In Mitochondria and the Future of Medicine, naturopathic doctor Lee Know tells the epic story of mitochondria - the widely misunderstood and often-overlooked powerhouses of our cells. The legendary saga began over two billion years ago, when one bacterium entered another without being digested, which would evolve to create the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that have been responsible for this life-giving energy.
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Understanding our humanity - the essence of who we are - is one of the deepest mysteries and biggest challenges in modern science. Why do we have bad moods? Why are we capable of having such strange dreams? How can metaphors in our language hold such sway on our actions? As we learn more about the mechanisms of human behavior through evolutionary biology, neuroscience, anthropology, and other related fields, we're discovering just how intriguing the human species is.
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3 out of 5 stars
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Somewhat Interesting but not Quite as Advertised
- De Adam J Duhame en 10-05-13
De: Robert Sapolsky, y otros
Lo que los oyentes dicen sobre Junk DNA
Calificaciones medias de los clientesReseñas - Selecciona las pestañas a continuación para cambiar el origen de las reseñas.
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Total4 out of 5 stars
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Ejecución5 out of 5 stars
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Historia4 out of 5 stars
- Amazon Customer
- 07-03-20
lamarck: 1 darwin: 0...
the last half century of biology owes an apology
apparently God don't make no junk after all.
this book is a snapshot of the tip of the iceberg from miles away. what a time to be alive
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esto le resultó útil a 2 personas
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Total4 out of 5 stars
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Ejecución4 out of 5 stars
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Historia3 out of 5 stars
- Julia Jones
- 04-20-22
Higher Understanding
You need to have higher education to fully grasp this book. Otherwise, it is a great book!
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esto le resultó útil a 1 persona
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Total5 out of 5 stars
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Ejecución5 out of 5 stars
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Historia5 out of 5 stars
- Sam C.
- 09-21-23
A great update
As a physician, this was a great update about advances in genetics. This was a great detailed basic science update. It had a mixture of many different Concepts mixed with clinical examples.
As with many great books, you can start with the appendix to get you fascinated.
I have a neighbor working in pharmaceuticals who mentioned in passing some of the technologies mentioned and this book helps to connect a lot of dots.
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Total1 out of 5 stars
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Ejecución1 out of 5 stars
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Historia2 out of 5 stars
- Marco
- 05-09-23
Don't bother with the audiobook
This book is a worse version of The Epigenetics Revolution by the same author. It is puzzling to me why a new book, with largely overlapping content and much worse editing, was needed.
The audiobook is particularly bad, no effort has been made into making it easier to follow for those who don't have access to the text. Figures keep being referenced, but no accompanying material was provided (this is perfectly possible, see for example Why We Sleep, which provides an accompanying PDF with all the relevant figures).
So I would stay away from this and instead read/listen to the previous, much better book The Epigenetics Revolution.
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Total2 out of 5 stars
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Ejecución1 out of 5 stars
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Historia3 out of 5 stars
- Christopher
- 02-21-21
perhaps a better textbook than a Saturday read
Nice British presenter, made me feel I was on hold with the bank. For eons.
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- Bill A
- 04-11-21
What’s the point
They write on dna or protein they insist on spending 20 minutes saying either the dna or protein codons... it’s annoying as hell
STOP
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esto le resultó útil a 7 personas