Episodes

  • Just the Facts: Tryptamine Therapeutics doses first patient in obesity-focused psilocin study

    Just the Facts: Tryptamine Therapeutics doses first patient in obesity-focused psilocin study
    Nov 22 2024
    Proactive’s Tylah Tully breaks down Just the Facts of the latest news from Tryptamine Therapeutics Ltd (ASX:TYP, OTC:TYPTF). The company has dosed the first participant in its Phase 1b trial of TRP-8803, a psilocin-based IV infusion, targeting obese individuals. The trial, conducted at CMAX Clinical Research in Adelaide, involves three obese participants and aims to compare pharmacokinetics between obese and non-obese groups. The initial treatment lasted 140 minutes. TRP-8803, designed for faster onset and precise control of the psychedelic state, offers neuroplastic benefits that may lead to adaptive changes in the brain, enhancing clinical outcomes. The trial builds on earlier Phase 1 results that demonstrated safety, efficacy, and optimal dosing rates. Interim results from the obese cohort are expected before year-end. This data will refine dosing protocols for future Phase 2 trials, which will explore specific indications, including weight-related conditions such as Binge Eating Disorder. The study highlights the cost-effectiveness of the initiative and its role in expanding the company’s dataset for broader applications. Tryptamine’s management is currently evaluating opportunities for Phase 2 trials and plans to provide updates as they progress. #ProactiveInvestors #TryptamineTherapeutics #ASX #TRP8803 #PsilocinResearch #Phase1bTrial #ObesityResearch #Neuroplasticity #PsilocybinAlternative #ClinicalTrials #InnovativeMedicine #CMAXResearch #TherapeuticAdvancements #PsychedelicTherapies #HealthOutcomes #Pharmacokinetics #MentalHealthResearch #BingeEatingDisorder #FutureOfMedicine #PatientCare #DataDrivenResearch #Phase2Planning
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    2 mins
  • Just the Facts: Evolution Energy Minerals advances Chilalo Project with site works

    Just the Facts: Evolution Energy Minerals advances Chilalo Project with site works
    Nov 22 2024
    Proactive’s Tylah Tully breaks down Just the Facts of the latest news from Evolution Energy Minerals Ltd (ASX:EV1). The company has initiated early site works for the Chilalo Graphite Project in Tanzania. Activities include constructing an access road and pre-clearing the plant site, key steps for facilitating future construction phases. The development follows the successful transfer of land and completion of compensation payments under the resettlement action plan. Evolution’s recently appointed CEO George Donne highlighted the commencement of these works as a significant milestone in the company’s journey toward the project’s commercialisation. Donne is an experienced mining executive and is tasked with overseeing financing and guiding the project into production. The initial works should be complete by year-end, providing the foundation for subsequent stages of development. The access road will ensure efficient transport of materials and personnel, while the cleared plant site prepares the area for construction. Evolution emphasises its commitment to positive community engagement and ensuring the Chilalo Project delivers benefits to the local population, supported by strong regional backing for the initiative. #ProactiveInvestors #EvolutionEnergy #ASX #JusttheFacts #ChilaloGraphiteProject #TanzaniaMining #GraphiteProduction #MiningNews #CommunityEngagement #SitePreparation #MiningProjects #ASXNews #GraphiteMining #SustainableMining #LocalImpact #MiningDevelopment #CEOAnnouncement #ConstructionStart #MiningLeadership #ResourceDevelopment #FutureProduction #ResettlementPlan #ProjectMilestones
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    2 mins
  • Just the Facts: Maximus Resources reports 92% gold recovery at Eagles Nest deposit

    Just the Facts: Maximus Resources reports 92% gold recovery at Eagles Nest deposit
    Nov 22 2024
    Proactive’s Tylah Tully breaks down Just the Facts of the latest news from Maximus Resources Ltd (ASX:MXR, OTC:MXRRF). The company has shared positive metallurgical test results from the Eagles Nest Gold Deposit, 7 kilometres south of its Wattle Dam Gold Project in Western Australia’s Eastern Goldfields. The tests show gold recovery rates ranging from 89.5% to 92.4%, confirming the deposit as free-milling and suitable for conventional gold processing. This includes recoveries of 90.5% in the oxide zone, 90.9% in transitional mineralisation, and 91.8% in primary mineralisation. The Eagles Nest resource is estimated at 42,500 ounces of gold at 2.0 g/t, with near-surface mineralisation enhancing its economic potential. The deposit remains open along a 3-kilometre untested strike, providing significant exploration upside. Maximus plans a follow-up drilling program in December to delineate shallow mineralisation and refine resource classification for a future mineral resource estimate (MRE) update. The company is also conducting additional metallurgical testing to optimise recovery processes and continues development studies aimed at reducing project risks. A mining proposal submission is targeted for next year. #ProactiveInvestors #MaximusResources #ASX #JusttheFacts #EaglesNestDeposit #GoldMining #GoldRecovery #MiningNews #EasternGoldfields #MineralResources #GoldExploration #DrillingProgram #MetallurgicalTesting #AustralianMining #MiningDevelopment #GoldProcessing #MiningEconomics #ExplorationUpdate
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    2 mins
  • Company Cornerstone Botala Energy: Driving sustainable energy in Africa

    Company Cornerstone Botala Energy: Driving sustainable energy in Africa
    Nov 22 2024
    Botala Energy Ltd (ASX: BTE) is advancing energy solutions in Southern Africa by integrating coal bed methane (CBM) and solar energy to address the region’s energy crisis. The company aims to help meet the United Nations' Sustainable Development Goal 7, which promotes affordable and sustainable energy access. Botala’s flagship Serowe CBM Project in Botswana is now fully owned by the company, with a 42% certified increase in CBM resources, totalling 454 billion cubic feet. Gas quality tests confirm a methane purity of up to 94%, ensuring commercial viability. Feasibility studies highlight economic potential, with a five-well pilot projected to generate up to 10 megawatts of electricity. Future plans include gas liquefaction, compression and integration into hybrid systems. In renewable energy, Botala has secured a 4 MW solar project and received environmental approval for the Leupane Energy Hub, which will feature a 500 MW solar facility and a 200 MW gas-fired plant. Botala commits 1% of revenue to community programs supporting employment and development. The company’s milestones include winning a solar project tender and advancing strategic energy hubs, aiming for energy security in Southern Africa. At the time of filming, BTE shares traded at 6.3 cents. #ProactiveInvestors #BotalaEnergy, #CompanyCornerstone #ASX, #EnergySolutions, #SouthernAfrica, #CoalBedMethane, #SolarEnergy, #EnergyCrisis, #SustainableDevelopment, #RenewableEnergy, #GasProjects, #SeroweCBM, #LeupaneEnergyHub, #HybridEnergy, #CleanEnergy, #CommunityInvestment, #EnergyAccess, #UNSDG7, #GreenEnergy, #AfricaEnergy, #BTE
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    3 mins
  • Exciting updates from Apollo Minerals' projects

    Exciting updates from Apollo Minerals' projects
    Nov 21 2024
    Apollo Minerals Ltd (ASX:APO) managing director Neil Inwood talks with Proactive’s Tylah Tully about the company’s latest activities, including its exciting exploration projects in Gabon. During the interview, Inwood detailed the maiden drill program results from the Slaney Gold Project, highlighting visible gold findings and the significance of being the first modern exploration of the region in seven decades. "This is only 20 metres along trend of trenching we’ve done previously," he said, emphasising the historical high-grade gold mine's potential. Inwood also shared plans for 2024, including a partnership with a reputable drilling company and the identification of new targets based on mapping and soil geochemistry. He further discussed progress at the Crusoe Zinc-Lead Project and announced an entitlement offer to engage existing shareholders in the company’s growth. With unfinished business from the current drill program and promising new targets, Apollo Minerals is set for an exciting year ahead. #ProactiveInvestors #ApolloMinerals #ASX #GoldExploration #GabonMining #SlaneyGold #ZincLeadProjects #InvestorsUpdate #MiningNews
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    5 mins
  • Connected Minerals makes uranium breakthrough in Namibia

    Connected Minerals makes uranium breakthrough in Namibia
    Nov 21 2024
    Connected Minerals makes uranium breakthrough in Namibia
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    4 mins
  • Race Oncology advances RNA epigenetics with FTO drug discovery at Monash

    Race Oncology advances RNA epigenetics with FTO drug discovery at Monash
    Nov 21 2024
    Race Oncology Ltd (ASX:RAC, OTC:RAONF) CEO Daniel Tillett joins Proactive’s Tylah Tully to discuss the FTO drug discovery program the company has concluded at Monash University’s Fragment Platform (MFP). The program successfully identified 39 molecular candidates (‘hits’) that bind specifically to the m6A RNA demethylase protein, FTO. These findings were validated using NMR spectroscopy and surface plasmon resonance. The program leverages NMR fragment screening to discover drug-like molecules that can regulate protein activity outside the enzyme's active site, offering an alternative to traditional high-throughput screening. The identified FTO-binding chemical scaffolds create opportunities for the development of patentable, first-in-class drugs targeting the m6A RNA epigenetic pathway. RNA epigenetics dysregulation, involving proteins like FTO, is linked to various cancers and metabolic diseases. However, selective inhibition of FTO is challenging due to structural similarities with related proteins in the ALKBH family. Race’s use of Monash’s curated chemical fragment library enabled the identification of unique FTO-binding structures. Race plans a ‘hit-to-lead’ campaign to refine these fragments into lead drug candidates, focusing on improving potency, selectivity, toxicity profiles, and metabolic properties. The company is currently evaluating whether to proceed with this resource-intensive phase. #ProactiveInvestors #RaceOncology, #ASX, #RNAEpigenetics, #DrugDiscovery, #CancerTherapies, #FTOProtein, #OncologyResearch, #Biotechnology, #NMRScreening, #Epigenetics, #RNARegulation, #PharmaceuticalInnovation, #CancerDrugs, #MetabolicDiseases, #MonashUniversity, #MedicinalChemistry, #CancerResearch, #TargetedTherapies, #PatentableDrugs, #BiotechInvestment
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    4 mins
  • Aclara Resources Secures $730K Grant to Advance AI-Driven Rare Earth Exploration in Chile

    Aclara Resources Secures $730K Grant to Advance AI-Driven Rare Earth Exploration in Chile
    Nov 21 2024
    Aclara Resources CFO Francois Motte joined Steve Darling from Proactive to announced the company has received a US$730,000 research, development, and innovation grant from the Chilean Economic Development Agency’s Innovation Management Division. Combined with Aclara’s own investment, the initiative will be funded with approximately $1 million to revolutionize rare earth element (REE) exploration using artificial intelligence (AI) models. The project employs advanced machine learning to analyze complex datasets in real time, focusing on the identification of REE mineralization within ionic clay deposits. By integrating field data gathered by Aclara’s Exploration Team, the AI system combines data processing power with geological interpretation to evaluate extensive land areas efficiently. This innovative approach is expected to optimize operational efficiency, reduce exploration costs, and minimize environmental impact, while also accelerating the identification of high-potential exploration targets. “This grant validates our commitment to technological innovation and sustainable exploration practices,” Motte said. “By deploying cutting-edge AI tools, we aim to enhance our ability to uncover rare earth resources critical to the energy transition.” Aclara Resources’ initiative represents a significant step forward in the exploration of ionic clay-hosted REE deposits, particularly in Chile, and positions the company as a leader in integrating technology and sustainability in mineral exploration. #proactiveinvestors #aclararesourcesinc #tsx #ara #mining #rareearths#AclaraResources #CarinaProject #GoiásMoU #MiningInvestment #RenewableEnergy #EnvironmentalSustainability #JobCreation #InfrastructureDevelopment #BrazilMining #SustainableMining #ProactiveInvestors #invest #investing #investment #investor #stockmarket #stocks #stock #stockmarketnews
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    5 mins