The Exquisite Machine
The New Science of the Heart
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The Exquisite Machine
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Narrated by:
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Polly Lee
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By:
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Sian Harding
About this listen
Your heart is a miracle in motion, a marvel of construction unsurpassed by any human-made creation. It beats 100,000 times every day—if you were to live to 100, that would be more than 3 billion beats across your lifespan. Despite decades of effort in labs all over the world, we have not yet been able to replicate the heart’s perfect engineering. But, as Sian Harding shows us in The Exquisite Machine, new scientific developments are opening up the mysteries of the heart. And this explosion of new science—ultrafast imaging, gene editing, stem cells, artificial intelligence, and advanced microscopy—has crucial, real-world consequences for health and well-being.
Harding—a world leader in cardiac research—explores the relation between the emotions and heart function, reporting that the heart not only responds to our emotions but creates them as well. The condition known as broken heart syndrome, for example, is a real disorder that can follow bereavement or stress.
The Exquisite Machine describes the evolutionary forces that have shaped the heart’s response to damage, the astonishing rejuvenating power of stem cells, how we can avoid heart disease, and why it can be so hard to repair a damaged heart. It tells the stories of patients who have had the devastating experiences of a heart attack, chaotic heart rhythms, or stress-induced acute heart failure. And it describes how cutting-edge technologies are enabling experiments and clinical trials that will lead us to new solutions to the worldwide scourge of heart disease.
©2022 Sian E. Harding (P)2022 Recorded BooksListeners also enjoyed...
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-
Story4.5 out of 5 stars 1,989
We humans like to think of ourselves as highly evolved creatures. But if we are supposedly evolution's greatest creation, why do we have such bad knees? Why do we catch head colds so often - 200 times more often than a dog does? How come our wrists have so many useless bones? And are we really supposed to swallow and breathe through the same narrow tube? Surely there's been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last.
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4 out of 5 stars
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From Pointless Bones to Broken Genes to...Aliens?
- By Katy.LED on 12-04-18
By: Nathan H. Lents
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Evolving Ourselves
- How Unnatural Selection and Nonrandom Mutation are Changing Life on Earth
- By: Juan Enriquez, Steve Gullans
- Narrated by: Rob Shapiro
- Length: 10 hrs and 50 mins
- Unabridged
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Overall4.5 out of 5 stars 204
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Performance4.5 out of 5 stars 178
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Story4.5 out of 5 stars 181
Why are conditions like autism, asthma, obesity, and allergies exploding at unprecedented rates? Why are we living longer, getting smarter, having far fewer kids? If Darwin were alive today, how would he explain this new world?
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5 out of 5 stars
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fascinating ideas and science
- By Joel on 07-04-15
By: Juan Enriquez, and others
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The Cancer Chronicles
- Unlocking Medicine's Deepest Mystery
- By: George Johnson
- Narrated by: Arthur Morey
- Length: 8 hrs and 19 mins
- Unabridged
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Overall4.5 out of 5 stars 62
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Performance4.5 out of 5 stars 53
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Story4.5 out of 5 stars 53
When the woman he loved was diagnosed with a metastatic cancer, science writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is a revolution under way - an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease.
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5 out of 5 stars
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A quick read - hard to put down
- By Digital Dilema on 09-06-13
By: George Johnson
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Missing Microbes
- How the Overuse of Antibiotics Is Fueling Our Modern Plagues
- By: Martin J. Blaser
- Narrated by: Patrick Lawlor
- Length: 8 hrs and 43 mins
- Unabridged
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Overall4.5 out of 5 stars 379
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Performance4.5 out of 5 stars 322
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Story4.5 out of 5 stars 324
In Missing Microbes, Dr. Martin J. Blaser invites us into the wilds of the human microbiome, where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the health and equilibrium of our body. Now this invisible eden is being irrevocably damaged by some of our most revered medical advances-antibiotics-threatening the extinction of our irreplaceable microbes with terrible health consequences.
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5 out of 5 stars
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Very enlightening and information well supported
- By James on 05-03-15
By: Martin J. Blaser
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A Nation in Pain
- Healing Our Biggest Health Problem
- By: Judy Foreman
- Narrated by: Karen White
- Length: 14 hrs and 57 mins
- Unabridged
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Overall4.5 out of 5 stars 33
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Performance4.5 out of 5 stars 33
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Story4.5 out of 5 stars 32
Published in partnership with the International Association for the Study of Pain, A Nation in Pain offers a sweeping, deeply researched account of the chronic pain crisis, from neurobiology to public policy, and presents practical solutions that are within our grasp today. Drawing on both her personal experience with chronic pain and her background as an award-winning health journalist, she guides us through recent scientific discoveries, including genetic susceptibility to pain.
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3 out of 5 stars
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Broad but superficial.
- By J. P. Murphy on 07-03-15
By: Judy Foreman
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Happy Accidents
- Serendipity in Major Medical Breakthroughs in the Twentieth Century
- By: Morton A. Meyers
- Narrated by: Richard Waterhouse
- Length: 12 hrs and 37 mins
- Unabridged
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Overall4.5 out of 5 stars 50
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Performance4 out of 5 stars 45
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Story4.5 out of 5 stars 44
Happy Accidents is a fascinating, entertaining, and highly accessible look at the surprising role serendipity has played in some of the most important medical discoveries in the 20th century. What do penicillin, chemotherapy drugs, X-rays, Valium, the Pap smear, and Viagra have in common? They were each discovered accidentally, stumbled upon in the search for something else. In discussing medical breakthroughs, Dr. Morton Meyers makes a cogent, highly engaging argument for a more creative, rather than purely linear, approach to science. And it may just save our lives!
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1 out of 5 stars
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Don't waste your money!
- By Amazon Customer on 03-20-16
By: Morton A. Meyers
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State of the Heart
- Exploring the History, Science, and Future of Cardiac Disease
- By: Haider Warraich
- Narrated by: Neil Shah
- Length: 11 hrs and 8 mins
- Unabridged
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Overall4.5 out of 5 stars 49
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Performance5 out of 5 stars 41
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Story4.5 out of 5 stars 40
In State of the Heart, the journey to rid the world of heart disease is shown to be reflective of the journey of medical science at large. We are learning not only that women have as much heart disease as men, but that the type of heart disease women experience is diametrically different from that in men. We are learning that heart disease and cancer may have more in common than we could have imagined. And we are learning how human evolution itself may have led to the epidemic of heart disease
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3 out of 5 stars
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Good information, bad organization
- By Conor Cox on 09-03-19
By: Haider Warraich
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The Compatibility Gene
- How Our Bodies Fight Disease, Attract Others, and Define Our Selves
- By: Daniel M. Davis
- Narrated by: Christopher Grove
- Length: 7 hrs and 48 mins
- Unabridged
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Overall4.5 out of 5 stars 52
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Performance4.5 out of 5 stars 42
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Story4.5 out of 5 stars 42
Most of the 25,000 genes we possess are the same for all of us. Compatibility genes are those that vary most from person to person and give each of us a unique molecular signature. These genes determine both the extent to which we are susceptible to a vast range of illnesses and the different ways each of us fights disease.
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5 out of 5 stars
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If interested in medicine, got to read
- By Howard Sterling on 06-29-16
By: Daniel M. Davis
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Heart 411
- The Only Guide to Heart Health You'll Ever Need
- By: Marc Gillinov MD, Steven Nissen MD
- Narrated by: Tom Weiner
- Length: 19 hrs and 51 mins
- Unabridged
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Overall4.5 out of 5 stars 25
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Performance4.5 out of 5 stars 22
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Story4.5 out of 5 stars 22
Are you one of the 82 million Americans currently diagnosed with cardiovascular disease - or one of the millions more who think they are healthy but are at risk? Whether your goal is to get the best treatment or to stay out of the cardiologist’s office, your heart’s health depends on accurate information and correct answers to key questions. In Heart 411 two renowned experts, heart surgeon Marc Gillinov and cardiologist Steven Nissen, tackle the questions their patients have raised over decades....
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5 out of 5 stars
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Review
- By PaulGreene on 09-11-21
By: Marc Gillinov MD, and others
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Reverse Heart Disease Now: Stop Deadly Cardiovascular Plaque Before It's Too Late
- By: Stephen Sinatra
- Narrated by: Kevin Pierce
- Length: 8 hrs and 58 mins
- Unabridged
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Overall4.5 out of 5 stars 71
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Performance4.5 out of 5 stars 64
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Story4.5 out of 5 stars 62
While most books focus solely on the role of cholesterol in heart disease, Reverse Heart Disease Now draws on new research that points to the surprising other causes. Two leading cardiologists draw on their collective 50 years of clinical cardiology research to show you how to combine the benefits of modern medicine, over-the-counter vitamins and supplements, and simple lifestyle changes to have a healthy heart.
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5 out of 5 stars
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I "Had" high blood pressure!
- By terryloher on 01-18-18
By: Stephen Sinatra
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The Emperor of All Maladies
- A Biography of Cancer
- By: Siddhartha Mukherjee
- Narrated by: Fred Sanders
- Length: 22 hrs and 18 mins
- Unabridged
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Overall5 out of 5 stars 4,689
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Performance5 out of 5 stars 4,110
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Story5 out of 5 stars 4,088
The Emperor of All Maladies reveals the many faces of an iconic, shape-shifting disease that is the defining plague of our generation. The story of cancer is a story of human ingenuity, resilience, and perseverance but also of hubris, arrogance, paternalism, and misperception, all leveraged against a disease that, just three decades ago, was thought to be easily vanquished in an all-out "war against cancer".
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5 out of 5 stars
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Incredible
- By S.R.E. on 03-02-16
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An Epidemic of Absence
- A New Way of Understanding Allergies and Autoimmune Diseases
- By: Moises Velasquez-Manoff
- Narrated by: Chris Sorensen
- Length: 17 hrs and 6 mins
- Unabridged
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Overall4.5 out of 5 stars 55
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Performance4.5 out of 5 stars 48
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Story4.5 out of 5 stars 49
An Epidemic of Absence asks what will happen in developing countries, which, as they become more affluent, have already seen an uptick in allergic disease: Will India end up more allergic than Europe? Velasquez-Manoff also details a controversial underground movement that has coalesced around the treatment of immune-mediated disorders with parasites. Against much of his better judgment, he joins these do-it-yourselfers and reports his surprising results.
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5 out of 5 stars
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The point of view from a Veterinarian immunologist
- By rtgymnast on 11-03-17
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Sicker, Fatter, Poorer
- The Urgent Threat of Hormone-Disrupting Chemicals on Our Health and Future . . . and What We Can Do About It
- By: Leonardo Trasande MD MPP
- Narrated by: Leonardo Trasande MD MPP
- Length: 6 hrs and 44 mins
- Unabridged
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Overall4.5 out of 5 stars 45
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Performance4.5 out of 5 stars 38
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Story4.5 out of 5 stars 38
Lurking in our homes, hiding in our offices, and polluting the air we breathe is something sinister. Something we’ve turned a blind eye to for far too long. Dr. Leonardo Trasande, a pediatrician, professor, and world-renowned researcher, tells the story of how our everyday surroundings are making us sicker, fatter, and poorer. Through a blend of narrative, scientific detective work, and concrete information about the connections between chemicals and disease, he reveals what we can do to protect ourselves and our families in the short-term, and how we can help bring the change we deserve.
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5 out of 5 stars
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The Must Read Book of 2019 is here early on Audio!
- By Ryan S on 12-21-18
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p53: The Gene That Cracked the Cancer Code
- By: Sue Armstrong
- Narrated by: Elizabeth Jasicki
- Length: 9 hrs and 55 mins
- Unabridged
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Overall4.5 out of 5 stars 125
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Performance4 out of 5 stars 109
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Story4.5 out of 5 stars 107
p53: The Gene That Cracked the Cancer Code reveals the tale of the search for this gene, as well as the excitement of the hunt for new cures - the hype, the lost opportunities, the blind alleys, and the thrilling breakthroughs. As the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms starts to take off at last, p53 is still at the forefront of the game. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.
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5 out of 5 stars
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Excellent story! Unfortunate narration at start
- By Adriana on 12-25-14
By: Sue Armstrong
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Ten Drugs
- How Plants, Powders, and Pills Have Shaped the History of Medicine
- By: Thomas Hager
- Narrated by: Angelo Di Loreto
- Length: 8 hrs and 39 mins
- Unabridged
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Overall4.5 out of 5 stars 4,890
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Performance4.5 out of 5 stars 4,233
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Story4.5 out of 5 stars 4,215
Beginning with opium, the “joy plant,” which has been used for 10,000 years, Thomas Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.
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4 out of 5 stars
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Engrossing to physicians & lay persons alike
- By C. White on 03-08-19
By: Thomas Hager
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Less Medicine, More Health
- 7 Assumptions That Drive Too Much Medical Care
- By: H. Gilbert Welch
- Narrated by: L. J. Ganser
- Length: 8 hrs and 18 mins
- Unabridged
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Overall5 out of 5 stars 102
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Performance5 out of 5 stars 91
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Story4.5 out of 5 stars 91
The author of the highly acclaimed Overdiagnosed describes seven widespread assumptions that encourage excessive, often ineffective, and sometimes harmful medical care. You might think the biggest problem in medical care is that it costs too much. Or that health insurance is too expensive, too uneven, too complicated - and gives you too many forms to fill out. But the central problem is that too much medical care has too little value.
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4 out of 5 stars
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The truth will set you free
- By Rene B Milner on 04-01-16
By: H. Gilbert Welch
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The Heart Healers
- The Misfits, Mavericks, and Rebels Who Created the Greatest Medical Breakthrough of Our Lives
- By: James Forrester MD
- Narrated by: Jonathan Yen
- Length: 15 hrs and 45 mins
- Unabridged
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Overall4.5 out of 5 stars 91
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Performance4.5 out of 5 stars 82
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Story4.5 out of 5 stars 82
At one time heart disease was a death sentence. By the middle of the 20th century, it was killing millions, and, as with the Black Death centuries before, physicians stood helpless. Visionaries, though, had begun to make strides earlier. On September 7, 1895, Ludwig Rehn successfully sutured the heart of a living man with a knife wound to the chest for the first time.
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5 out of 5 stars
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Great review of the landmark achievements in Cardiology.
- By Trauma NP on 12-14-15
What listeners say about The Exquisite Machine
Average customer ratingsReviews - Please select the tabs below to change the source of reviews.
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Overall5 out of 5 stars
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Performance5 out of 5 stars
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Story5 out of 5 stars
- Adding
- 04-19-23
Loved it. Couldnt stop listening
Great overview of cardiovascular science and research. Very Interesting. Couldn't put this audiobook down. Insight into lifestyle, medication, genetics, emergency procedures along with research into artificial hearts and stem cells.
You may learn more than your primary care physician after listening to this book and be better able to understand yourself or a loved one's care
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