What if the biggest challenge of our time isn’t living longer, but living better?

In this episode, we’re tackling one of humanity’s greatest accomplishments—and perhaps its most overlooked challenge: longevity. As more people live past 100, our systems—healthcare, finance, career planning, and even our cultural perceptions of aging—need a fundamental overhaul.

We’re joined by Dr. Andrew Scott, author of The Longevity Imperative, and Vijay Pande a16z’s Bio & Health general partner, to explore how a shift from “sick care” to “health care” could transform our lives. Together, we discuss the implications of longer lifespans, from the individual choices that can improve our healthspans to the economic and societal shifts required to sustain a healthier, more productive aging society.

Join us as we reimagine the future of aging, where living to 100 can be more than survival—it can be a life well-lived.

Resources:

Find Andrew on X: https://x.com/profandrewscott?lang=en

Find Vijay on X: https://x.com/vijaypande

Learn more about The Longevity Imperative:

https://profandrewjscott.com/the-longevity-imperative/

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

America is a country of immense wealth, but our manufacturing infrastructure is struggling to keep pace.

In this episode, we discuss the overlooked crisis of American manufacturing and what it means for our national resilience. a16z’s Oliver Hsu hosts a conversation with founders Jordan Black (Senra Systems), Chris Power (Hadrian), and Bryon Hargis (Castelion) on why we need to revive our industrial base — and fast.

From outdated regulations to the adoption of automation, they break down the “death by a thousand paper cuts” that has left our production capabilities lagging behind. Yet, it’s not all grim: these founders share how their companies are taking bold, vertically integrated approaches to reinvent the sector and reclaim America's industrial edge.

Resources:

Find Chris on X: https://x.com/2112Power

Find Jordan on X: https://x.com/jordan__black

Find Bryon on X: https://x.com/hargsb

Find Oliver on X: https://x.com/oyhsu

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Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

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Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

2024 has been a milestone year for autonomous tech.

Waymo’s fully autonomous driver has surpassed 20 million miles, while FAA approvals now allow commercial drones to fly without visual observers, advancing air autonomy in unprecedented ways.

In this special live recording from SF Tech Week, a16z partner Erin Price-Wright moderates a panel of experts from three key domains—air, land, and sea—to explore the latest real-world deployments of autonomous systems, the impact of new chips on cost and efficiency, building full-stack solutions, managing risk, and the evolving role of regulation in driving these technologies forward.

Joining the conversation is Macario Namie, CMO of Skydio, discussing the transition from consumer drones to enterprise and government use; Vijay Patnaik, Head of Product at Applied Intuition, who shares insights on developer tools and software for autonomous vehicles; and Peter Bowman-Davis, engineering fellow at a16z, diving into maritime autonomy based on his work at Saronic.

Resources:

Find Macario on LinkedIn: https://www.linkedin.com/in/macario-namie-bb529/

Find Vijay on LinkedIn: https://www.linkedin.com/in/vijaysaipatnaik/

Find Peter on LinkedIn: https://www.linkedin.com/in/peter-bowman-davis/

Find Erin on Twitter: https://x.com/espricewright

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Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

We take you behind the scenes of our newly released, annual State of Crypto Report — a16z crypto's analysis of the latest data and trends that have defined the industry in 2024.

This year's report features some brand new insights, from estimating the number of real crypto users globally, to understanding how much interest in crypto swing states may have ahead of the U.S. election. We also dig into infrastructure improvements to blockchains and key applications — including stablecoins, AI, and so-called DePIN. Be sure to visit a16zcrypto.com for all this and more including a new “Builder Energy” dashboard, which we’ll discuss on the show.

Joining me to talk about the findings are lead data scientist and report author Daren Matsuoka and CTO Eddy Lazzarin. The first voice you'll hear after mine is Daren's, then Eddy's.

a16z crypto resources:

-State of Crypto Report 2024

-Builder Energy dashboard

-Estimating the number of real crypto users

by Daren Matsuoka and Eddy Lazzarin

Stay Updated:

Let us know what you think: https://ratethispodcast.com/a16z

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Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

What does Rich Sutton’s "Bitter Lesson" reveal about the decisions Tesla is making in its pursuit of autonomy?

In this episode, we dive into Tesla’s recent "We, Robot" event, where they unveiled bold plans for the unsupervised full-self-driving Cybercab, Robovan, and Optimus—their humanoid robot, which Elon Musk predicts could become “the biggest product ever.”

Joined by a16z partners Anjney Midha and Erin Price-Wright, we explore how these announcements reflect the evolving intersection of hardware and software. We’ll unpack the layers of the autonomy stack, the sources of data powering it, and the challenges involved in making these technologies a reality.

Anjney, with his experience in computer vision and multiplayer tech at Ubiquity6, and Erin, an AI expert focused on the physical world, share their unique perspectives on how these advancements could extend far beyond the consumer market.

For more insights, check out Erin’s articles linked below.

Resources:

Find Anj on Twitter: https://x.com/anjneymidha

Find Erin on Twitter: https://x.com/espricewright

Read Erin’s article ‘A Software-Driven Autonomy Stack Is Taking Shape’: https://a16z.com/a-software-driven-autonomy-stack-is-taking-shape/

AI for the Physical World: https://a16z.com/ai-for-the-physical-world/

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Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In 2024, marking 10 years since its launch, Apple Pay now boasts hundreds of millions of consumers in 78 markets, at checkout on millions of websites and apps, in tens of millions of stores worldwide, and is supported by more than 11,000 bank and network partners.

In this episode, a16z General Partner Alex Rampell sits down with Jennifer Bailey, VP of Apple Pay and Apple Wallet, to explore how Apple has transformed digital payments.

Jennifer reveals how Apple Pay and Apple Wallet have grown beyond payments to include transit cards, car keys, and more. They also discuss the challenges of driving adoption, the future of digital wallets, and Jennifer’s insights for entrepreneurs.

Resources:

Find Jennifer on LinkedIn: https://www.linkedin.com/in/jbaileyz

Find Alex on X: https://x.com/arampell

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Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Lisa Su has transformed AMD into a global leader in AI and high-performance computing.

In this episode of the AI Revolution (AIR) series , Bob Swan, a16z Operating Partner and former CEO of Intel, sits down with Lisa Su, CEO of AMD, to discuss how her leadership has propelled AMD’s growth and positioned the company at the forefront of AI innovation.

They explore AMD’s pivotal role in democratizing the benefits of gen AI, the evolution of AI computing, and the importance of open ecosystems and partnerships in driving technological breakthroughs.

Resources:

Find Lisa on X: https://x.com/lisasu

Find Bob on X: https://x.com/bobswan

Stay Updated:

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Deepfakes—AI-generated fake videos and voices—have become a widespread concern across politics, social media, and more. As they become easier to create, the threat grows. But so do the tools to detect them.

In this episode, Vijay Balasubramaniyan, cofounder and CEO of Pindrop, joins a16z’s Martin Casado to discuss how deepfakes work, how easily they can be made, and what defenses we have. They’ll also explore the role of policy and regulation in this rapidly changing space.

Have we lost control of the truth? Listen to find out.

Resources:

Find Vijay on Twitter: https://x.com/vijay_voice

Find Martin on Twitter: https://x.com/martin_casado

Stay Updated:

Let us know what you think: https://ratethispodcast.com/a16z

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Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.