Metabolism plays an important role in our day to day lives. Our metabolism changes over time as we age, with conditions such as osteoarthritis and in people who are above a healthy weight. The study of the small molecules chemicals in biological samples or the study of metabolomics is an emerging field in research. On this week's episode of Joint Action, we are joined by Ron June and Hope Welhaven to discuss the role of the metabolome in osteoarthritis.

Dr Ron June is a Professor and bioengineer based at Montana State University, USA. His research interests include osteoarthritis and biomechanics. He also recently founded a company, OpenBioWorks, seeking to provide commercial metabolomic profiling services.

Dr Hope Welhaven’s research focusses on investigating the metabolism of musculoskeletal tissues during times of health and disease, such as osteoarthritis. She uses mass spectrometry-based techniques including metabolomics and imaging to identify and examine metabolic mechanisms involved in disease progression.

RESOURCES

Journal articles

· The metabolome of individuals with knee osteoarthritis is influenced by 18-months of an exercise and weight loss intervention and sex: the IDEA trial

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