🚴‍♀️ Biking and the Battle Against Itch! 🎙️

Live from the charming canals of Amsterdam at the EADV 2024 meeting, we sit down with the ever-energetic Dr. Perla Lansang from Toronto!

🍁 She's ditched cabs and metros to embrace the Dutch biking culture, even bringing her own bike across the pond! 🚲🌍 From navigating streets with more bikes than people 😲 to packing rain ponchos for unpredictable weather ☔, Dr. Lansang shares her love for the city.

🍽️ She's on a mission to find the best delectable mini Dutch pancakes topped with butter and powdered sugar 🥞✨. And while we couldn't coax the secret behind her infamous kale smoothie 🥬🥤, we dive into something even more exciting.

We explore late breaking fresh new data presented at EADV on nemolizumab, the new therapeutic targeting IL-31 that's set to revolutionize atopic dermatitis treatment! What does this new 56-week data from an interim analysis of the phase III ARCADIA long-term extension study mean for your patients?

🧪🔥 Discover how this game-changing drug offers rapid itch relief—some patients feel better in just days! 😮🧖‍♂️

We'll unpack nemolizumab’s long-term efficacy and safety in atopic dermatitis, discuss the stellar safety profile, and delve into how it is poised to transform patient care by improving sleep 😴 and overall quality of life 🌟.

This episode is packed with laughs 😂, insightful clinical pearls 🩺, and a sprinkle of Dutch delight! 🎧🌷

Learning Objectives:

1. Understand the pivotal role of IL-31 in atopic dermatitis and why nemolizumab's targeting of this cytokine is a breakthrough.
2. Review the design, key findings, and clinical significance of the Arcadia 1 and 2 long-term extension data up to 56 weeks.
3. Discuss the rapid efficacy and excellent safety profile of nemolizumab and its impact on itch relief, clearance and patient adherence.
4. Evaluate the clinical implications of integrating nemolizumab into practice and its potential to transform atopic dermatitis management.

ABOUT Dr. Perla Lansang, MD, FRCPC ( Dermatology)

Toronto, ON

Dr. Perla Lansang is a full-time staff dermatologist and associate professor in the Division of Dermatology, University of Toronto where she is the Division Head of Dermatology at Sunnybrook Health Sciences Centre. She is also cross appointed at the Section of Paediatric Dermatology at the Hospital for Sick Children, and the Division of Obstetric Medicine at Sunnybrook Health Sciences Centre.

She completed her medical school and dermatology residency at the University of the Philippines-Philippine General Hospital. Having done fellowships in paediatric dermatology at The Hospital for Sick Children and in advanced medical dermatology at Sunnybrook Health Sciences Centre, Dr. Lansang’s practice is a mixture of pediatric, adolescent, and adult dermatology, with a special focus on psoriasis, atopic dermatitis, cutaneous lymphoma, pregnancy dermatoses, and general medical dermatology. She has a special interest in immune-mediated skin diseases and has extensive clinical and research experience in many areas of immunodermatology.

📻www.skinandjoints.ca

✉️info@skinandjoints.ca

📻www.skinandjoints.ca

✉️info@skinandjoints.ca

🎙 Amsterdam Stories, Delta Force & A Game-Changing Topical for Chronic Hand Eczema

🎉✨ Melinda Knows Best is BACK! 🚀💥

This time, Dr. Gooderham brings us a heavyweight showdown 🥊 between a new topical superhero 🦸‍♀️ and the reigning oral champ 💊 in the battle against Chronic Hand Eczema! reporting live from the European Academy of Dermatology and Venereology (EADV) Congress in the beautiful city of Amsterdam! 🇳🇱✨

In this special episode, we’re diving into the Delta Force Trial – a bold study comparing topical delgocitinib to oral alitretinoin for chronic hand eczema 💊🧴

👀 Dr. Gooderham spills the beans on impressive results, rapid relief, and how this new treatment is about to change the game for dermatologists and patients alike. 🎉

Oh, and don’t worry, we didn’t forget to ask about her Amsterdam adventures! 🌍 Did she run into some famous faces at dinner? 🍽️👀 Tune in for the scoop!

💡 Melinda Knows Best will keep you at the cutting edge of CHE breakthroughs. 👩‍⚕️✨

🎯 Learning Objectives:

1. Explore the Delta Force Trial Findings: Understand the significance of the Delta Force trial comparing topical delgocitinib to oral alitretinoin for chronic hand eczema. 🧴💊
2. Evaluate the Efficacy of Topicals vs Orals for chronic hand eczema: Learn about the early onset of symptom relief with delgocitinib, including i reductions in HEXI scores and patient quality of life improvements. ⏱️📉
3. Identify Key Real-World Implications: Discuss how this new topical treatment can shift the landscape for clinicians and patients, offering rapid, safe relief without the headaches (literally!) of oral therapies. 💡
4. Dive into secondary endpoints, including itch and pain relief, and how this data compares to other major clinical trials in hand eczema treatment. 📊🔬

ABOUT Dr.Melinda Gooderham, MD, FRCPC ( Dermatology)

Toronto, ON

Melinda Gooderham MD MSc FRCPC Dr. Gooderham is a Dermatologist and Medical Director at the SKiN Centre for Dermatology and an Investigator with Probity Medical Research. She is an Assistant Professor at Queens University and a Consultant Physician at the Peterborough Regional Health Centre. She is a fellow of the Royal College of Physicians and Surgeons of Canada.

Dr. Gooderham has been the principal investigator for over 200 clinical trials and she practices with a focus on inflammatory diseases of the skin. She also contributes to several peer-reviewed dermatology publications as an associate editor, reviewer, and has been an author of 205 articles. She enjoys lecturing to global audiences on new therapies for skin diseases.

📻www.skinandjoints.ca

✉️info@skinandjoints.ca

📻www.skinandjoints.ca

✉️info@skinandjoints.ca

🎙️ Skin Joins Podcast Wrap-Up: Sunny Stories & Cool Pools 🌞

We welcome back Dr. Michele Ramien, who graced our podcast last July from the sunny World Congress of Dermatology in Singapore. 🌏 Fast forward, she reflects on dermatology innovation from vibrant city of San Diego! 🌴

Dr. Ramien shares a delightful (and chilly) San Diego story about renting a house wit, a freezing-cold pool, and a group of eager people determined to swim🏊‍♂️❄️

We deep dive into the exciting highlights from the American Academy of Dermatology conference. Dr. Ramien, attending AAD for the first time in a while, reveals fascinating pearls and🩺✨ innovative treatments including the potential for disease remission in young patients, as well as fresh new insights on melasma and post-inflammatory hyperpigmentation in Asian skin 🌟

Dr. Ramien also touches on the importance of adapting treatments for different skin types and the promising future of pediatric dermatology. 👶💡

Learning Objectives:

1. 🌍 Understand the global advancements in dermatology from the AAD conference.
2. 🧴 Learn about innovative treatments for atopic dermatitis, including pediatric applications.
3. 🎨 Explore the management of melasma and post-inflammatory hyperpigmentation in diverse skin types.
4. 🧒 Discover the potential for disease remission in young patients with early and targeted treatments.

Tune in for a blend of personal stories, professional insights, and a sneak peek into the future of dermatological treatments. 📚🔍

Stay tuned, stay informed, and as always, keep your skin happy 🌟🧴

Supported by an IME Grant from Pfizer

ABOUT Dr. Michele L. Ramien

Pediatric Dermatologist | Calgary

Dr. Michele Ramien is an academic dermatologist based at the Alberta Children’s Hospital, in the foothills of the Rocky Mountains in Calgary, Canada. She has both pediatric and general medical dermatology practices, with a focus on teaching and mentoring the next generations and research interests in eczema management, patient education, and severe cutaneous reactions in children.

Dr. Ramien enjoys volunteer leadership positions as a way to meet colleagues across the country, like-minded and not, who believe that a small group of thoughtful, committed individuals can change and improve dermatology and delivery of care in Canada.

📻www.skinandjoints.ca

✉️info@skinandjoints.ca

🎙️ More than Skin Deep Insights with Dr. Lauren Lam!🎙️

👩‍⚕️💬 As we get close to wrapping up our coverage of AAD 2024, get ready as we welcome back Dr. Lauren Lam. We dive deep into her recent experience at the AAD in sunny San Diego. 🌞🏖️

Learning Objectives:

1. 🧠 Understand the practical applications of translational medicine in dermatology, particularly in treating chronic skin conditions.
2. 🛠️ Identify key clinical pearls and advancements in dermatology that can be immediately implemented in practice to improve patient care.

What’s on the agenda for this mini-podcast drop?

1. 🌟 San Diego Stories: From bar hopping in a Japanese-themed spot 🌸🍹 to pelican watching at the pier 🦩📸, Lauren shares her unique experiences and the vibrant cultural mix that San Diego offers.
2. 🔍 Translational Medicine Takeaways: Discover how the latest advancements in bench-to-bedside research are transforming dermatological practices. 🧬🩺
3. 💡 Clinical Pearls Galore:

• Hidradenitis Suppurativa Insights: Understand why de-roofing is essential even with biologics 🩹🔬.
• Alopecia Areata Breakthroughs: Learn about the impact of JAK inhibitors 🧑‍🦲➡️🧑‍🦰.
• Pyoderma Gangrenosum Progress: Hear about the promising results of IL-36 inhibitors in treating this challenging condition 💉🌟.

Join us for a lively episode that blends professional insights with personal anecdotes, and don't miss out on the laughter and wisdom Dr. Lam brings to the table 🎧✨

ABOUT Dr. Lauren Lam

Dermatologist | Calgary

Dr. Lauren Lam is a Canadian & American board-certified dermatologist. She is a native Calgarian who completed her medical school training at the University of Calgary & her dermatology residency at the University of Alberta. Since graduating, Dr. Lam has become a Clinical Lecturer with the University of Alberta. Her particular passions in dermatology are acne & hidradenitis suppurativa deroofings. In addition to her regular practice, she volunteers on overseas medical trips. Her passion for providing care for under-served populations has taken her to Nunavut & rural Fiji. Outside of medicine, Dr. Lam is a proud aunt to 4 dogs, culinary enthusiast & international explorer.

📻www.skinandjoints.ca

✉️info@skinandjoints.ca

🎙️ Melinda Knows Best at the AAD! 🌟

We’ve got a special LATEBREAKER episode for you, continuing our coverage from the American Academy of Dermatology in San Diego!

👟💡 Pro Tip: Don't miss Dr. Gooderham’s advice on navigating massive convention centers in style and comfort!

We dive into the highly anticipated Delta 3 study, shedding light on long-term safety and efficacy of Delgocitinib cream for Chronic Hand Eczema.

• Subjects who completed the 16-week treatment period in one of the parent trials DELTA 1 and DELTA 2 were treated with twice daily delgocitinib cream as needed to control their chronic hand eczema for 36 weeks.

Practical Tips for Dermatology Practices 🏥💼

• Adapting treatment plans for chronic hand eczema.
• Benefits of as-needed treatment approaches for better patient outcomes.

Dr. Gooderham’s Conference Adventures 🛫👩‍⚕️👨‍⚕️

• Dr. Gooderham also shares her intriguing encounters from Toronto to San Diego, including a surprise meeting with April Armstrong and an old friend from med school. 🛫

Episode Learning Objectives:

1. Understand the primary and secondary endpoints of the Delta 3 study and its implications for treating chronic hand eczema.
2. Learn about the safety profile of Delgocitinib cream and its significance in long-term treatment plans.
3. Gain insights into real-world application of delgocitinib and patient adherence strategies for topical treatments

Lace up those sneakers, grab a protein bar, and join us for a walk through the latest dermatological advancements! 🥾🍫

🎙️ Melinda Knows Best at the AAD – where expert insights meet real-world application (pun intended)📍📍

Episode supported by an IME Grant from LEO Pharma

ABOUT Dr.Melinda Gooderham, MD, FRCPC ( Dermatology)

Dermatologist | Toronto

Toronto, ON

Melinda Gooderham MD MSc FRCPC Dr. Gooderham is a Dermatologist and Medical Director at the SKiN Centre for Dermatology and an Investigator with Probity Medical Research. She is an Assistant Professor at Queens University and a Consultant Physician at the Peterborough Regional Health Centre. She is a fellow of the Royal College of Physicians and Surgeons of Canada.

Dr. Gooderham has been the principal investigator for over 200 clinical trials and she practices with a focus on inflammatory diseases of the skin. She also contributes to several peer-reviewed dermatology publications as an associate editor, reviewer, and has been an author of 205 articles. She enjoys lecturing to global audiences on new therapies for skin diseases.

References

1. Gooderham M. Long-term safety and efficacy of delgocitinib cream for up to 36 weeks in adults with chronic hand eczema: results of the phase 3 open-label extension DELTA 3 trial. Presented at: 2024 American Academy of Dermatology Annual Meeting; March 8-12, 2024; San Diego, CA.

📻www.skinandjoints.ca

✉️info@skinandjoints.ca

🎙️🌞 Tight Spaces & Hair-Raising Breakthroughs – Live from AAD San Diego! 🎙️🌴

Join Skin and Joints Podcast AAD Guest Faculty and Vancouver based dermatologist, Dr,Diana Diao, as she navigates the cramped quarters of a historic boutique hotel in the Gaslamp Quarter—tiny rooms, weird noises, and all! 🏨😅

Dr. Diao explore groundbreaking sessions on alopecia areata, revealing innovative treatments and valuable clinical insights that are shaping the future of dermatology.

🌟💊Don't miss out on Dr. Diao's top clinical takeaways that could revolutionize treatment approaches for dermatologists everywhere. Whether it's systemic therapies for extensive scalp involvement or tailored treatments for unique patient profiles, this episode is packed with insights that promise to enhance patient care.

💬 Tune in, transform your approach with pearls that could change your practice overnight!

🎧✨ #SkinJointsPodcast #DermatologyInDepth

Learning Objectives:

1. Gain Insight into New Treatments for Alopecia Areata: Learn about the latest advancements and clinical trials discussed at AAD, including newly approved treatments and their application in real world practice.
2. Appreciate the Psychosocial Aspects of Dermatological Conditions: Recognize the significant emotional and social challenges faced by patients with alopecia areata and the importance of addressing these in real world practice.
3. Implement Clinical Pearls in Practice: Discover actionable tips and strategies that can be immediately applied to improve patient outcomes.

#SkinAndJointsPodcast #DermatologyDeepDive #SanDiegoSun
Episode supported by an IME Grant from Pfizer and Bausch Health.

ABOUT DR. DIANA DIAO FRCPC, FAAD

Dr. Diana Diao is a Dermatologist and a Clinical Instructor in the Department of Dermatology and Skin Science at the University of British Columbia. She is a consultant dermatologist at both Vancouver General Hospital and St. Paul’s Hospital. Dr. Diao practices medical and procedural dermatology, with a special interest in using energy-based modalities such as lasers to treat a variety of skin conditions.

Dr. Diao completed both her Medical Doctorate degree and dermatology residency training at the University of British Columbia, and is a Fellow of the Royal College of Physicians and Surgeons of Canada. Dr. Diao is a mother, a published author, and has presented her work at conferences such as the World Congress of Dermatology and the American Academy of Dermatology meetings. Dr. Diao is also fluent in Mandarin.

📻www.skinandjoints.ca

✉️info@skinandjoints.ca