In this episode of Curing with Sound, Lynn Dengel, MD, a surgical oncologist at UVA Health, discusses her groundbreaking clinical trial combining focused ultrasound with immunotherapy to treat patients with advanced melanoma. She shares insights into how this Foundation-funded trial – which is still enrolling patients – could help those who don't benefit from standard immunotherapy alone. Key points from the conversation:

• Melanoma is the most invasive type of skin cancer and accounts for the majority of skin cancer deaths. More than 100,000 Americans are diagnosed with melanoma each year.
• The study will enroll approximately 11 participants with advanced melanoma who are receiving a cancer immunotherapy drug (PD-1 antibody blockade) as part of their regular care and having the melanoma surgically removed.
• Dr. Dengel explains how focused ultrasound not only targets tumor tissue but may also create an enhanced environment for immunotherapy to work more effectively.
• As a senior advisor to the Foundation's immunotherapy program, Dr. Dengel highlights the value of cross-institutional collaboration in advancing focused ultrasound research and improving patient outcomes.

UVA Health Study: Seeking Adult Patients with Advanced Melanoma Who are Receiving Immune Therapy and Who are Planning to Receive Surgery - MORE INFO

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Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.

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In this episode of Curing with Sound, Robert Palmer shares his transformative experience with focused ultrasound for prostate cancer. Robert details his procedure, which, unlike traditional treatments, allowed him to avoid overnight hospitalization and return to normal activities within ten days. Now cancer-free, Robert is a passionate advocate for focused ultrasound technology and has spoken to U.S. policymakers about his experience. Key points from the conversation:

• The TULSA-PRO procedure is an incision-free, outpatient treatment that uses MRI-guided focused ultrasound technology. Compared to traditional treatments, it requires only a brief recovery period and has minimal side effects.
• The American Medical Association has issued three Category I CPT® codes for the TULSA-PRO device. The codes, which take effect on January 1, 2025, are used by insurance companies to reimburse medical procedures. This milestone marks a significant step toward making this treatment more accessible to patients.
• Palmer's experience has led him to become a champion for focused ultrasound technology, participating in Capitol Hill advocacy work and helping to educate other men about this minimally invasive treatment option.

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Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.

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In this special episode of Curing with Sound, Foundation team members share an overview of the advancements in focused ultrasound over the past year and provide a look at what’s ahead for the field in 2025. From groundbreaking clinical applications to increased global adoption, this episode highlights the field’s remarkable growth and its impact on patients and animals alike. The discussion covers a wide range of topics, including the latest research on focused ultrasound for Alzheimer’s disease, breast cancer, chronic pain, brain tumors, and veterinary applications, as well as innovations in gene and cell therapy. Our experts also address the critical transition from research to commercial treatment and the challenges of increasing awareness among clinicians and patients. Expert topics include:

• Neal Kassell, MD, highlights focused ultrasound’s transition to commercial treatment, with advancements in prostate cancer, Alzheimer’s, Parkinson’s, and cancer immunotherapy.
• Suzanne LeBlang, MD, provides an update on the latest breakthroughs in Alzheimer’s research, including the use of focused ultrasound to safely open the blood-brain barrier. She also discusses neuromodulation for psychiatric conditions like depression and OCD.
• Lauren Powlovich, MD, shares progress in chronic pain management using thalamic ablation and neuromodulation, and improving outcomes for brain tumor treatments like glioblastoma.
• Kelsie Timbie, PhD, explores veterinary applications, including noninvasive treatments for cancer and diabetes in pets.
• Frédéric Padilla, PhD, discusses gene and cell therapy and explains how focused ultrasound is overcoming delivery challenges through blood-brain barrier opening, nanoparticle therapies, and partnerships to advance treatments for brain diseases.

EPISODE TRANSCRIPT ---------------------------- QUESTIONS? Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances.

Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.

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