In this episode of Curing with Sound, Lynn Dengel, MD, a surgical oncologist at UVA Health, discusses her groundbreaking clinical trial combining focused ultrasound with immunotherapy to treat patients with advanced melanoma. She shares insights into how this Foundation-funded trial – which is still enrolling patients – could help those who don't benefit from standard immunotherapy alone. Key points from the conversation:

• Melanoma is the most invasive type of skin cancer and accounts for the majority of skin cancer deaths. More than 100,000 Americans are diagnosed with melanoma each year.
• The study will enroll approximately 11 participants with advanced melanoma who are receiving a cancer immunotherapy drug (PD-1 antibody blockade) as part of their regular care and having the melanoma surgically removed.
• Dr. Dengel explains how focused ultrasound not only targets tumor tissue but may also create an enhanced environment for immunotherapy to work more effectively.
• As a senior advisor to the Foundation's immunotherapy program, Dr. Dengel highlights the value of cross-institutional collaboration in advancing focused ultrasound research and improving patient outcomes.

UVA Health Study: Seeking Adult Patients with Advanced Melanoma Who are Receiving Immune Therapy and Who are Planning to Receive Surgery - MORE INFO

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In this episode of Curing with Sound, Robert Palmer shares his transformative experience with focused ultrasound for prostate cancer. Robert details his procedure, which, unlike traditional treatments, allowed him to avoid overnight hospitalization and return to normal activities within ten days. Now cancer-free, Robert is a passionate advocate for focused ultrasound technology and has spoken to U.S. policymakers about his experience. Key points from the conversation:

• The TULSA-PRO procedure is an incision-free, outpatient treatment that uses MRI-guided focused ultrasound technology. Compared to traditional treatments, it requires only a brief recovery period and has minimal side effects.
• The American Medical Association has issued three Category I CPT® codes for the TULSA-PRO device. The codes, which take effect on January 1, 2025, are used by insurance companies to reimburse medical procedures. This milestone marks a significant step toward making this treatment more accessible to patients.
• Palmer's experience has led him to become a champion for focused ultrasound technology, participating in Capitol Hill advocacy work and helping to educate other men about this minimally invasive treatment option.

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In this special episode of Curing with Sound, Foundation team members share an overview of the advancements in focused ultrasound over the past year and provide a look at what’s ahead for the field in 2025. From groundbreaking clinical applications to increased global adoption, this episode highlights the field’s remarkable growth and its impact on patients and animals alike. The discussion covers a wide range of topics, including the latest research on focused ultrasound for Alzheimer’s disease, breast cancer, chronic pain, brain tumors, and veterinary applications, as well as innovations in gene and cell therapy. Our experts also address the critical transition from research to commercial treatment and the challenges of increasing awareness among clinicians and patients. Expert topics include:

• Neal Kassell, MD, highlights focused ultrasound’s transition to commercial treatment, with advancements in prostate cancer, Alzheimer’s, Parkinson’s, and cancer immunotherapy.
• Suzanne LeBlang, MD, provides an update on the latest breakthroughs in Alzheimer’s research, including the use of focused ultrasound to safely open the blood-brain barrier. She also discusses neuromodulation for psychiatric conditions like depression and OCD.
• Lauren Powlovich, MD, shares progress in chronic pain management using thalamic ablation and neuromodulation, and improving outcomes for brain tumor treatments like glioblastoma.
• Kelsie Timbie, PhD, explores veterinary applications, including noninvasive treatments for cancer and diabetes in pets.
• Frédéric Padilla, PhD, discusses gene and cell therapy and explains how focused ultrasound is overcoming delivery challenges through blood-brain barrier opening, nanoparticle therapies, and partnerships to advance treatments for brain diseases.

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John Dutton is a patient with both Parkinson's disease and Multiple Sclerosis. In this episode, John shares how focused ultrasound treatment dramatically improved his quality of life by virtually eliminating his Parkinson-related tremors. He discusses his progression of symptoms, details his focused ultrasound procedure, and encourages others to explore this treatment as a viable option for managing tremors associated with Parkinson's disease.

Watch John's patient story and documentary film SHOW TRANSCRIPT ---------------------------- QUESTIONS? Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances.

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In this episode of Curing with Sound, John Lukens, PhD, a Professor of Neuroscience at the University of Virginia, shares his groundbreaking research on the connection between the immune system and the brain in combating neurological disorders. He discusses the role of focused ultrasound in enhancing immunotherapy and opening new treatment possibilities for conditions like Alzheimer's, ALS, and brain tumors.

Dr. Lukens explains how recent discoveries about the brain's lymphatic system are reshaping our understanding of neurodegenerative diseases. He also details how focused ultrasound is being used to temporarily open the blood-brain barrier, allowing therapies to reach targeted areas more effectively. The conversation sheds light on how these approaches are pushing the boundaries of treatment possibilities for both neurodegenerative and cancer-related brain conditions.

SHOW TRANSCRIPT ---------------------------- QUESTIONS? Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances.

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In this episode of Curing with Sound, three leading experts in focused ultrasound technology share their groundbreaking work in pancreatic cancer treatment. Dr. Feng Wu from Oxford University, Dr. Jae Young Lee from Seoul National University Hospital, and Dr. Joan Vidal-Jové from Barcelona's Comprehensive Tumor Center discuss their innovative approaches to treating one of medicine's most challenging cancers using noninvasive focused ultrasound techniques. The episode provides insights into the evolution and future of focused ultrasound technology in cancer treatment. The experts detail how their work addresses key challenges in pancreatic cancer treatment, from enhancing drug delivery to activating immune responses. Key Points:

• Focused ultrasound technology shows particular promise in addressing the unique challenges of pancreatic cancer, including the ability to precisely target tumors while preserving surrounding critical structures.
• Multiple treatment pathways are being explored simultaneously: thermal ablation (HIFU), mechanical stimulation for drug delivery enhancement, and histotripsy for immune system activation, offering new hope for patients with limited treatment options.
• Dr. Lee shares exciting results from his phase II clinical trial combining focused ultrasound with chemotherapy, achieving a 63% objective response rate.
• Dr. Wu discusses combining HIFU ablation with drug delivery to overcome limitations in treating pancreatic cancer.
• Dr. Vidal-Jové reveals how histotripsy treatment has shown remarkable immune system activation effects.

SHOW TRANSCRIPT ---------------------------- QUESTIONS? Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances.

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In this compelling episode of Curing with Sound, Rima Youssef shares her transformative journey battling severe obsessive-compulsive disorder (OCD) since childhood. Learn how a focused ultrasound clinical trial at Sunnybrook Health Sciences Center offered hope when traditional treatments failed, leading to a remarkable turnaround in Rima's life.

Rima's story is a testament to the potential of focused ultrasound in treating neurological disorders. From the onset of her symptoms at age six to participating in a groundbreaking clinical trial at Sunnybrook in 2021, Rima candidly discusses her struggles with debilitating OCD and the impact of the focused ultrasound procedure on her recovery. Her experience sheds light on the challenges of living with treatment-resistant OCD and the life-changing potential of this innovative, noninvasive technology.

Key points from the conversation:

• Rima's OCD journey, including early onset at age 6 and escalation of symptoms that by age 12, left her unable to attend school or even play outside
• Rima's decision to participate in the focused ultrasound clinical trial and her experience with the procedure
• The gradual improvement in Rima's symptoms post-treatment, allowing her to return to work and regain a sense of normalcy in her life
• Rima's advocacy for wider accessibility of focused ultrasound treatment for OCD patients

SHOW TRANSCRIPT ---------------------------- QUESTIONS? Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances.

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In recognition of Breast Cancer Awareness Month, Dr. Greg Czarnota, a senior scientist and radiation oncologist at Sunnybrook Research Institute in Toronto, discusses his innovative research using focused ultrasound in breast cancer treatment. Dr. Czarnota shares promising results from his phase I clinical trial using focused ultrasound-stimulated microbubbles to enhance radiotherapy in patients with advanced breast cancers. Key points from the conversation include:

• The origins of Dr. Czarnota's interest in focused ultrasound and its application in enhancing radiotherapy.
• He shares details of the upcoming phase II clinical trials that will be enrolling patients with inoperable breast cancer.
• Technical advances with the Arrayus focused ultrasound device could treat larger and more complex tumors.

Dr. Czarnota has also developed ultrasound imaging methods to detect cell death. SHOW TRANSCRIPT ---------------------------- QUESTIONS? Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances.

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