What if you could increase your energy, improve your focus, and optimize your brain health with just one simple lozenge? Dr. Scott Sherr, an expert in health optimization, joins us on the show once more to discuss methylene blue, a powerful mitochondrial enhancer that has been used for over a century. He explains how this compound boosts cognition, helps fight infections, and even improves endurance for athletes. If you’ve been feeling sluggish, struggling with brain fog, or looking for a smarter approach to supplements, this episode is packed with science-backed insights you can start using today.

How long will you live? Take our quiz today to find out at ageist.com/longevity-quiz

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Timeline Nutrition: Our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with the code “AGEIST” at TimelineNutrition.com/ageist.

BON CHARGE: Harness the power of both infrared and red light therapy in the comfort of your own home with the Red Light Face Mask from BON CHARGE. To try their professional-grade technology for yourself, use the code “AGEIST15” for 15% off sitewide.

fatty15: C15:0 is the first essential fatty acid to be discovered in 90 years. fatty15 is on a mission to replenish your C15:0 levels and restore your long-term health. Get 15% off their 90-day subscription Starter Kit here or enter the code “AGEIST” at checkout.

Chapters

(00:00) Introduction to Methylene Blue
(02:24) Methylene Blue's Health Benefits
(08:03) The History and Mechanism of Methylene Blue
(13:00) Cognitive Effects and Mitochondrial Function
(18:20) Dosage and Timing for Methylene Blue
(24:17) Practical Applications and Endurance Benefits(
(35:19) Mitochondrial Health and Aging
(37:39) Methylene Blue: A Path to Health Optimization
(45:22) Utilizing Methylene Blue for Performance
(52:05) Methylene Blue and Red Light Therapy Synergy
(58:03) Practical Applications and Future of Methylene Blue

Key Moments
“Methylene blue works like oxygen in your cells, helping your body produce energy even in low-oxygen environments.”

“If you don’t have working mitochondria in your brain, you won’t have optimal cognitive function.”

“Stress, poor sleep, and toxins in our environment are killing our mitochondria—this is why so many people feel tired all the time.”

Connect With Dr. Scott Sherr & Troscriptions

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Instagram (@drscottsherr)

Troscriptions

Methylene Blue

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What if you could improve your memory, decision-making, and focus just by making small tweaks to your daily routine? Cognitive psychologist and author Therese Huston, PhD, joins us to share practical, science-backed strategies for boosting brain health at any age. She explains why stress kills creativity, how dancing can actually grow new brain cells, and why older adults often make better big-picture decisions than younger ones. Whether you want to sharpen your focus or protect your memory, this episode offers actionable advice to help you think and perform at your best.

How long will you live? Take our quiz today to find out! Visit ageist.com/longevityquiz

Thanks to Our Sponsors
LMNT Electrolytes — our number one electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.

Troscriptions — Precision, pharmaceutical-grade nootropics for peak performance. Whether you need laser focus, mental clarity, or a boost in cognitive endurance, Troscriptions delivers science-backed results. Use code AGEIST for 10% off.

Fatty15 – C15 is the first essential fatty acid to be discovered In 90 years. Fatty15 is on a mission to replenish your C15 levels and restore your long-term health. Get 15% off their 90-day subscription Starter Kit here or enter code: AGEIST at checkout.

Chapters

(00:00)
Introduction to Therese Huston, Ph.D

(05:54)
Strategies for Enhancing Creativity

(11:09)
The Role of Emotions in Decision Making

(17:56)
Memory Challenges and Solutions

(28:24)
Creating Connections for Memory

(29:58)
Understanding Brain Changes with Age

(32:09)
The Benefits of Dance for Brain Health

(36:02)
Cognitive Advantages of Aging

(43:08)
Harnessing Binaural Beats for Focus

(51:09)
Practical Tips for Brain Health

Key Moments
“One of the best ways to get creative is to bring your stress levels down.”

“Your brain at 50 or 60 is actually better at big-picture thinking because the two hemispheres are working together more efficiently.”

“Taking a dance class for six months can literally grow new neurons in your hippocampus, which helps memory.”

Connect With Dr. Huston
Website: theresehuston.com

Twitter: https://twitter.com/ThereseHuston

Check out the full interview transcript

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How do you maximize health span and avoid the slow decline often associated with aging? Rudy Inaba, an expert in performance health and longevity, explains why data-driven fitness and personalized interventions are the future. He breaks down the importance of VO2 max as a predictor of longevity, the impact of structured exercise on metabolic health, and why the best path to aging well isn’t found in exotic supplements but in consistent, foundational habits. He also shares the latest advancements in medical technology, from musculoskeletal scans to plasmapheresis, offering insights into how science is reshaping the way we approach long-term health.

How long will you live? Take our quiz today to find out! Visit ageist.com/longevityquiz

Thanks to Our Sponsors
Troscriptions — Precision, pharmaceutical-grade nootropics for peak performance. Whether you need laser focus, mental clarity, or a boost in cognitive endurance, Troscriptions delivers science-backed results. Use code: AGEIST at checkout to save 10% on your order.

Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist.

LMNT Electrolytes — our number one electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.

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Chapters

(00:14) Introduction to Cenegenics and Longevity Medicine

(03:22) Rudy Inaba's Journey and Background

(06:13) The Role of Data in Health Optimization

(09:02) The Importance of VO2 Max in Longevity

(12:13) Cenegenics: A Comprehensive Approach to Health

(15:08) The Evolution of Patient Care at Cenegenics

(18:01) The Pursuit of Optimal Health and Performance

(25:45) The Evolution of Health Awareness

(27:05) Exploring Plasmapheresis and Autoimmune Health

(29:45) Innovations in Longevity and Health Technologies

(34:10) The Importance of Multidisciplinary Approaches

(37:43) Holistic Health: Connecting the Dots

(41:25) Empowerment Through Small Choices

Key Moments
Exercise is the best thing we could put in a pill.

Every decision you make has the potential for a win.

If you want to improve longevity, start by improving your fitness—everything else follows.

Connect With Rudy and Cenegenics
Website: cenegenics.com

LinkedIn: linkedin.com/in/rudyinaba

Instagram: instagram.com/rudy.inaba

Check out the full interview transcript

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Teemu Arina, author of Biohacker's Handbook and one of the movement’s pioneers, believes biohacking may have lost its way. In this episode, he lays out a different approach to longevity. He argues that extreme health routines often do more harm than good, and that true well-being comes from adaptability, not rigid optimization. Teemu also shares why AI-driven personal health plans could replace cookie-cutter protocols, and how we can rethink aging as a balance between discipline and enjoying life. If you’re tired of endless supplement stacks and prescriptive morning routines, this conversation offers a fresh perspective on what actually works.

How long will you live? Take our quiz today to find out! Visit ageist.com/longevityquiz

Thanks to Our Sponsors
Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist.

LMNT Electrolytes — our number one electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.

BON CHARGE: Want to try the hottest sauna blanket on the market? Check out BON CHARGE’s Infrared Sauna Blanket, which is designed to provide easy access to the benefits of infrared heat therapy in the comfort of your own home, here.


Key Moments
Many high performers chasing optimization are just running from their own trauma.

The problem with perfect health routines is that it can become a prison.

You don’t need to live forever—you need to live well.

Connect With Teemu
Website: www.teemuarina.com
Instagram: @teemuarina
biohackersummit.com
Holo Habits App: holohabits.com
Book: Biohacker’s Handbook – biohackingbook.com

Check out the full interview transcript

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What if AI could analyze your health data and tell you exactly what to do to live longer? Guy Leitersdorf, CEO of Longevity AI, joins us to explain how his platform uses real-time biomarkers, behavioral science, and AI to optimize health decisions. Instead of one-size-fits-all advice, Longevity AI acts as a personal health coach, adjusting its guidance based on your habits, preferences, and biological markers. On this week’s episode of The AGEIST Podcast, we discuss the five key aging conditions, the role of real-time health nudges, and how AI-powered insights can help physicians move from reactive care to true preventative medicine.

How long will you live? Take our quiz today to find out! Visit ageist.com/longevity-quiz

Thanks to Our Sponsors
BON CHARGE: Want to try the hottest sauna blanket on the market? Check out BON CHARGE’s Infrared Sauna Blanket, which is designed to provide easy access to the benefits of infrared heat therapy in the comfort of your own home, here.

fatty15: C15:0 is the first essential fatty acid to be discovered in over 90 years. fatty15 is on a mission to replenish your C15:0 levels and restore your long-term health. Get 15% off your 90-day subscription Starter Kit here or enter code “AGEIST” at checkout.

LMNT Electrolytes: Our number-one electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.

Key Moments
“Nobody likes to treat their health as a chore, so we match habits to what people actually want to do.”

“Physicians don’t have time to analyze every piece of data—AI can harmonize it all and provide real-time, personalized insights.”

“The question isn’t just what you can do to improve your health, it’s what you will do—and that’s where behavioral science comes in.”

Connect With Guy Leitersdorf & Longevity AI
Longevity AI

Longevity AI LinkedIn

Guy Leitersdorf LinkedIn

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Longevity AI - X

Guy Leitersdorf - X

Longevity AI YouTube

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For more on Guy Leitendorf’s insights and Longevity AI, listen to his full interview on The AGEIST Podcast and/or check out the full episode transcript.

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Are the everyday products in our homes quietly harming us? Jill Czarnik, co-founder of The Tribalist, explains how microplastics, unregulated chemicals, and overconsumption are impacting our health in ways we often overlook. She shares practical, manageable steps for reducing exposure, from water filtration to simplifying personal care routines. This episode is a must-listen for anyone looking to take control of their environment and make choices that support long-term well-being.

How long will you live? Take our quiz today to find out! Visit ageist.com/quiz

Thanks to Our Sponsors
LMNT Electrolytes — Our number one electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.

Timeline Nutrition — Our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist.

Fatty15 – C15:0 is the first essential fatty acid to be discovered in over 90 years. fatty15 is on a mission to replenish your C15:0 levels and restore your long-term health. Get 15% off their 90-day subscription Starter Kit here or enter code "AGEIST" at checkout.

Key Moments
Microplastics are everywhere and nowhere—because we can’t see them, we ignore them, but they’re in every organ of our bodies.

You don’t have to overhaul your life overnight, but small changes—like swapping out your tea bags or filtering your water—can add up to big health improvements.

We think more stuff equals a better life, but the reality is, simplifying what we own and use can dramatically improve our well-being.

Helpful Links
Best RO Filter, no installation required:

https://www.amazon.com/dp/B0BGK4BQ2D?language=en_US&th=1&psc=1&tag=thetribalists-20

Impact of microplastics on health:

https://www.amazon.com/Sicker-Fatter-Poorer-Hormone-Disrupting-Chemicals-ebook/dp/B0789F6K8Z?ref_=ast_author_mpb

Jill’s book, The Plastic-Free Diet:

https://theplasticfreediet.com/

Connect with Jill
hello@thetribalist.com

thetribalist.com/

Full Episode Transcript

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Neil Markey, co-founder of Beckley Retreats, shares his journey from Army Ranger to leading advocate for psychedelics and mindfulness. Drawing from his own struggles with trauma and burnout in the service, Neil explains how meditation and professionally guided psychedelic experiences transformed his life. We discuss the benefits of neuroplasticity, emphasizing how intentional habits after transformative experiences can rewire our brains for long-term change. Whether you're seeking healing, self-improvement, or even a little adventure, Neil’s insights illuminate a path to deeper connection, clarity, and purpose.

How long will you live? Take our quiz today to find out at ageist.com/longevity-quiz

Thanks to Our Sponsors
Fatty15 – C15:0 is the first essential fatty acid to be discovered in over 90 years. fatty15 is on a mission to replenish your C15:0 levels and restore your long-term health. Get 15% off their 90-day subscription Starter Kit here or enter code "AGEIST" at checkout.

SuppCo – SuppCo is currently in beta and users can get 100% FREE access by going to supp.co/AGEIST. Podcast listeners will also get early access to SuppCo's founding membership when it launches in early 2025.

Blue Zones Kitchen – Want meals crafted with taste and longevity in mind? Consider what you put on your plate and get a little help from Blue Zones Kitchen. Click here and save $2 on any bowl.

Key Moments
Psychedelics can settle the central nervous system, creating clarity that allows us to see our stories and patterns more objectively.

Meditation isn’t just a tool—it’s the foundation for living a more present and intentional life.

Transformation requires habits; without them, even profound breakthroughs are temporary.

Connect With Neil Markey
Website: Beckley Retreats
Instagram:@neilpmarkey

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Michelle MacDonald, coach and daughter of Joan MacDonald (a.k.a. Train With Joan), is a fitness expert and the founder of Wonder Woman Coaching. This week, she joins us to challenge outdated narratives about aging and health. Michelle explains why muscle loss isn’t inevitable and how lifestyle choices shape physical and mental wellness. She shares the transformative story of coaching her mother, Joan, from obesity to thriving health, emphasizing the importance of habits over quick fixes. Tune in to learn why fitness isn’t about perfection but about creating sustainable routines that prioritize strength, vitality, and self-love.

How long will you live? Take our quiz today to find out! Visit: ageist.com/longevityquiz

Thanks to Our Sponsors

LMNT Electrolytes: our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.

Timeline Nutrition: Our number one supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist.

SuppCo – SuppCo is currently in beta and users can get 100% FREE access by going to supp.co/AGEIST. Podcast listeners will also get early access to SuppCo's founding membership when it launches in early 2025.

Key Moments
Sarcopenia isn’t inevitable—it’s a lifestyle choice. If you don’t use your muscles, you lose them.

You’re not invisible. Whatever you decide to be, you leave ripples in the water all around you.

Getting in fabulous shape isn’t rocket science. It’s simple, consistent effort over time.

Connect With Michelle MacDonald
Website: Wonder Woman Coaching
Instagram: @michellemacdonaldofficial
Podcast: Stronger By Design for Women

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Full Episode Transcript

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