Good Genes Gone Bad
A Short History of Vaccines and Biologics: Failures, Successes, Controversies
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Good Genes Gone Bad
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Narrado por:
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Mishal Varma
Acerca de esta escucha
The field of biotechnology has evolved over the past four decades, developing medicines which are curing diseases. But this journey of success has been tough and arduous, built upon the shoulders of major failures.
Good Genes Gone Bad highlights seven such colossal failures in drug development - all of which culminated in the development of novel drugs - weaving together various analogies through the stories and thus allowing the reader to understand complex biological phenomena. These stories include treatment of medical conditions such as genetic clotting disorder (haemophilia), childhood-diarrhoea (rotavirus vaccine), preventing HIV infection, activation of the immune systems to treat cancer, gene therapy for treatment of diseases caused by gene-defects/mutations, cell therapy for treatment of leukaemias, and finally the success of Biocon's approval of the first biologic drug for breast cancer.
Written by the former R&D head of Biocon, India's largest pharmaceutical company, Good Genes Gone Bad is a fascinating look at the complex world of medicine and drug development, providing the readers with a sense of magnitude of challenges and the extent of difficulty that it takes to make novel medicines.
©2021 Narendra Chirmule (P)2022 Random House AudioLos oyentes también disfrutaron...
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5 out of 5 stars
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In to the abyss we ascend, a scary future
- De Philomath en 06-17-17
De: Jennifer A. Doudna, y otros
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The Language of Life
- DNA and the Revolution in Personalized Medicine
- De: Francis S. Collins
- Narrado por: Greg Itzin
- Duración: 10 h y 45 m
- Versión completa
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General4 out of 5 stars 148
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Narración:4.5 out of 5 stars 99
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Historia4 out of 5 stars 98
A scientific and medical revolution has crept up on us, based on study after study, from hundreds of laboratories around the world. It is no longer just a theoretical shift: every one of us will be touched by it, and many of us already have been. The meaning of disease, our understanding of the human body, and crucial decisions about what we all need to know and what choices we make about our health are at stake. Welcome to the new world of personalized medicine.
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5 out of 5 stars
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The future of medicine
- De Ronald E en 04-12-10
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Happy Accidents
- Serendipity in Major Medical Breakthroughs in the Twentieth Century
- De: Morton A. Meyers
- Narrado por: Richard Waterhouse
- Duración: 12 h y 37 m
- Versión completa
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General4.5 out of 5 stars 49
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Narración:4 out of 5 stars 44
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Historia4.5 out of 5 stars 43
Happy Accidents is a fascinating, entertaining, and highly accessible look at the surprising role serendipity has played in some of the most important medical discoveries in the 20th century. What do penicillin, chemotherapy drugs, X-rays, Valium, the Pap smear, and Viagra have in common? They were each discovered accidentally, stumbled upon in the search for something else. In discussing medical breakthroughs, Dr. Morton Meyers makes a cogent, highly engaging argument for a more creative, rather than purely linear, approach to science. And it may just save our lives!
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1 out of 5 stars
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Don't waste your money!
- De Amazon Customer en 03-20-16
De: Morton A. Meyers
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Viruses, Plagues, and History
- Past, Present, and Future
- De: Michael B. A. Oldstone
- Narrado por: L.J. Ganser
- Duración: 13 h y 38 m
- Versión completa
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General4.5 out of 5 stars 561
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Narración:4.5 out of 5 stars 476
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Historia4.5 out of 5 stars 476
The story of viruses and humanity is a story of fear and ignorance, of grief and heartbreak, and of great bravery and sacrifice. Michael Oldstone tells all these stories as he illuminates the history of the devastating diseases that have tormented humanity, focusing mostly on the most famous viruses. For this revised edition, Oldstone includes discussions of new viruses like SARS, bird flu, virally caused cancers, chronic wasting disease, and West Nile. Viruses, Plagues, and History paints a sweeping portrait of humanity's long-standing conflict with our unseen viral enemies.
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4 out of 5 stars
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very detailed, but very statistical
- De ekhensel15 en 01-12-19
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p53: The Gene That Cracked the Cancer Code
- De: Sue Armstrong
- Narrado por: Elizabeth Jasicki
- Duración: 9 h y 55 m
- Versión completa
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General4.5 out of 5 stars 125
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Narración:4 out of 5 stars 109
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Historia4.5 out of 5 stars 107
p53: The Gene That Cracked the Cancer Code reveals the tale of the search for this gene, as well as the excitement of the hunt for new cures - the hype, the lost opportunities, the blind alleys, and the thrilling breakthroughs. As the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms starts to take off at last, p53 is still at the forefront of the game. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.
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5 out of 5 stars
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Excellent story! Unfortunate narration at start
- De Adriana en 12-25-14
De: Sue Armstrong
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The Compatibility Gene
- How Our Bodies Fight Disease, Attract Others, and Define Our Selves
- De: Daniel M. Davis
- Narrado por: Christopher Grove
- Duración: 7 h y 48 m
- Versión completa
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General4.5 out of 5 stars 53
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Narración:4.5 out of 5 stars 43
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Historia4.5 out of 5 stars 43
Most of the 25,000 genes we possess are the same for all of us. Compatibility genes are those that vary most from person to person and give each of us a unique molecular signature. These genes determine both the extent to which we are susceptible to a vast range of illnesses and the different ways each of us fights disease.
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5 out of 5 stars
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If interested in medicine, got to read
- De Howard Sterling en 06-29-16
De: Daniel M. Davis
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Between Hope and Fear
- A History of Vaccines and Human Immunity
- De: Michael Kinch
- Narrado por: Mel Foster
- Duración: 15 h y 59 m
- Versión completa
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General4.5 out of 5 stars 41
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Narración:4.5 out of 5 stars 37
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Historia4.5 out of 5 stars 37
Between Hope and Fear tells the remarkable story of vaccine-preventable infectious diseases and their social and political implications. While detailing the history of vaccine invention, Michael Kinch reveals the ominous reality that our victories against vaccine-preventable diseases are not permanent - and could easily be undone. Between Hope and Fear relates the remarkable intersection of science, technology, and disease that has helped eradicate many of the deadliest plagues known to man.
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4 out of 5 stars
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Enjoyed
- De Minsi Zhang en 05-03-20
De: Michael Kinch
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Editing Humanity
- The CRISPR Revolution and the New Era of Genome Editing
- De: Kevin Davies
- Narrado por: Kevin Davies
- Duración: 16 h y 17 m
- Versión completa
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General4.5 out of 5 stars 76
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Narración:4.5 out of 5 stars 65
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Historia4.5 out of 5 stars 65
Engrossing and captivating, Editing Humanity takes listeners inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to edit the DNA of any organism down to the individual building blocks of the genetic code. Davies introduces listeners to arguably the most profound scientific breakthrough of our time. He tracks the scientists on the front lines of its research to the patients whose powerful stories bring the narrative movingly to human scale.
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4 out of 5 stars
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Excellent content, solid execution
- De Samuel Finlayson en 01-25-21
De: Kevin Davies
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The Emperor of All Maladies
- A Biography of Cancer
- De: Siddhartha Mukherjee
- Narrado por: Fred Sanders
- Duración: 22 h y 18 m
- Versión completa
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General5 out of 5 stars 4,736
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Narración:5 out of 5 stars 4,145
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Historia5 out of 5 stars 4,123
The Emperor of All Maladies reveals the many faces of an iconic, shape-shifting disease that is the defining plague of our generation. The story of cancer is a story of human ingenuity, resilience, and perseverance but also of hubris, arrogance, paternalism, and misperception, all leveraged against a disease that, just three decades ago, was thought to be easily vanquished in an all-out "war against cancer".
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5 out of 5 stars
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Incredible
- De S.R.E. en 03-02-16
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Missing Microbes
- How the Overuse of Antibiotics Is Fueling Our Modern Plagues
- De: Martin J. Blaser
- Narrado por: Patrick Lawlor
- Duración: 8 h y 43 m
- Versión completa
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General4.5 out of 5 stars 385
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Narración:4.5 out of 5 stars 328
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Historia4.5 out of 5 stars 330
In Missing Microbes, Dr. Martin J. Blaser invites us into the wilds of the human microbiome, where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the health and equilibrium of our body. Now this invisible eden is being irrevocably damaged by some of our most revered medical advances-antibiotics-threatening the extinction of our irreplaceable microbes with terrible health consequences.
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5 out of 5 stars
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Very enlightening and information well supported
- De James en 05-03-15
De: Martin J. Blaser
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The Truth About Cancer
- De: Ty M. Bollinger
- Narrado por: Ty M. Bollinger
- Duración: 9 h y 11 m
- Versión completa
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General4.5 out of 5 stars 319
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Narración:4.5 out of 5 stars 277
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Historia4.5 out of 5 stars 276
One out of three women alive today, and one out of two men, will face a cancer diagnosis, according to the World Health Organization. Ty Bollinger takes this personally: in the course of a decade, he says, "I lost my entire family to cancer. I don't believe I had to lose them." The Truth about Cancer has been written for one simple reason: to share the knowledge we need to protect ourselves, treat ourselves, and in some cases save our lives or the lives of those we love.
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5 out of 5 stars
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save a life with this valuable information.
- De edwin matias en 12-30-16
De: Ty M. Bollinger
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Influenza
- The Hundred-Year Hunt to Cure the 1918 Spanish Flu Pandemic
- De: Dr. Jeremy Brown
- Narrado por: Holter Graham
- Duración: 6 h y 28 m
- Versión completa
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General4.5 out of 5 stars 360
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Narración:4.5 out of 5 stars 309
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Historia4.5 out of 5 stars 307
On the 100th anniversary of the devastating pandemic of 1918, Jeremy Brown, a veteran ER doctor, explores the troubling, terrifying, and complex history of the flu virus, from the origins of the Great Flu that killed millions, to vexing questions such as: are we prepared for the next epidemic, should you get a flu shot, and how close are we to finding a cure?
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5 out of 5 stars
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Important read
- De Kathryn C. en 12-21-18
De: Dr. Jeremy Brown
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An Epidemic of Absence
- A New Way of Understanding Allergies and Autoimmune Diseases
- De: Moises Velasquez-Manoff
- Narrado por: Chris Sorensen
- Duración: 17 h y 6 m
- Versión completa
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General4.5 out of 5 stars 55
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Narración:4.5 out of 5 stars 48
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Historia4.5 out of 5 stars 49
An Epidemic of Absence asks what will happen in developing countries, which, as they become more affluent, have already seen an uptick in allergic disease: Will India end up more allergic than Europe? Velasquez-Manoff also details a controversial underground movement that has coalesced around the treatment of immune-mediated disorders with parasites. Against much of his better judgment, he joins these do-it-yourselfers and reports his surprising results.
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5 out of 5 stars
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The point of view from a Veterinarian immunologist
- De rtgymnast en 11-03-17
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The HPV Vaccine on Trial
- Seeking Justice for a Generation Betrayed
- De: Mary Holland, Kim Mack Rosenberg, Eileen Iorio
- Narrado por: Caroline Slaughter
- Duración: 13 h y 41 m
- Versión completa
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General5 out of 5 stars 59
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Narración:4.5 out of 5 stars 51
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Historia5 out of 5 stars 52
Cancer strikes fear in people’s hearts around globe. So the appearance of a vaccine to prevent cancer - as we are assured the human papillomavirus (HPV) vaccine will - seemed like a game-changer. Since 2006, over 80 countries have approved the vaccine, with glowing endorsements from the world’s foremost medical authorities. Bringing in over $2.5 billion in annual sales, the HPV vaccine is a pharmaceutical juggernaut. Yet scandal now engulfs it worldwide. The HPV Vaccine on Trial is a shocking tale, chronicling the global efforts to sell and compel this alleged miracle.
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5 out of 5 stars
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Outstanding Investigative Book!
- De Barbara Loeppke en 10-02-19
De: Mary Holland, y otros
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Rigor Mortis
- How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions
- De: Richard Harris
- Narrado por: Joe Delafield
- Duración: 5 h y 56 m
- Versión completa
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General4.5 out of 5 stars 116
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Narración:4.5 out of 5 stars 99
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Historia4.5 out of 5 stars 98
American taxpayers spend $30 billion annually funding biomedical research, but over half of these studies can't be replicated due to poor experimental design, improper methods, and sloppy statistics. Bad science doesn't just hold back medical progress, it can sign the equivalent of a death sentence for terminal patients. In Rigor Mortis, Richard Harris explores these urgent issues with vivid anecdotes, personal stories, and interviews with the top biomedical researchers. We need to fix our dysfunctional biomedical system - before it's too late.
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5 out of 5 stars
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Eye opening introduction to biomedical R&D
- De Amazon Customer en 09-18-18
De: Richard Harris
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Welcome to the Microbiome
- Getting to Know the Trillions of Bacteria and Other Microbes In, On, and Around You
- De: Rob DeSalle, Susan L. Perkins
- Narrado por: Stephen McLaughlin
- Duración: 7 h y 25 m
- Versión completa
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General4.5 out of 5 stars 36
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Narración:4.5 out of 5 stars 35
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Historia4.5 out of 5 stars 34
Suddenly, research findings require a paradigm shift in our view of the microbial world. The Human Microbiome Project at the National Institutes of Health is well under way, and unprecedented scientific technology now allows the censusing of trillions of microbes inside and on our bodies as well as in the places where we live, work, and play. This intriguing, up-to-the-minute book for scientists and nonscientists alike explains what researchers are discovering about the microbe world and what the implications are for modern science and medicine.
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5 out of 5 stars
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I learned so much from this book. I am happy.
- De Jonathan Miller en 09-08-18
De: Rob DeSalle, y otros
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The Deeper Genome
- Why There Is More to the Human Genome than Meets the Eye
- De: John Parrington
- Narrado por: John Lee
- Duración: 9 h
- Versión completa
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General4 out of 5 stars 106
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Narración:4 out of 5 stars 91
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Historia4 out of 5 stars 92
Over a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way.
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3 out of 5 stars
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Great Scientific Writing/ Wrong Narrator
- De Richard en 11-24-15
De: John Parrington
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Evolving Ourselves
- How Unnatural Selection and Nonrandom Mutation are Changing Life on Earth
- De: Juan Enriquez, Steve Gullans
- Narrado por: Rob Shapiro
- Duración: 10 h y 50 m
- Versión completa
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General4.5 out of 5 stars 205
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Narración:4.5 out of 5 stars 179
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Historia4.5 out of 5 stars 182
Why are conditions like autism, asthma, obesity, and allergies exploding at unprecedented rates? Why are we living longer, getting smarter, having far fewer kids? If Darwin were alive today, how would he explain this new world?
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5 out of 5 stars
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fascinating ideas and science
- De Joel en 07-04-15
De: Juan Enriquez, y otros