Episodes

  • Obesity and the new science of weight loss | Dr. Louis J Aronne

    Obesity and the new science of weight loss | Dr. Louis J Aronne
    Jun 27 2024
    Obesity is a physiological condition that can be managed with the right education and treatment. In today's episode, Dr. Louis J. Aronne, a leading expert in obesity research, sheds light on the science behind weight management and obesity treatment. Dr. Aronne dives into groundbreaking weight loss medications. He also explores how lifestyle and eating habits affect long-term health and why medications combined with dietary changes can unlock transformative results. Louis J. Aronne, M.D. is a leading authority on obesity and its treatment. He’s a former president of The Obesity Society, which publishes the peer-reviewed scientific journal Obesity, of which Dr. Aronne is an associate editor. He has also authored more than 60 papers and book chapters on the topic. 🌱 Try our new plant based wholefood supplement - Daily 30 *Naturally high in copper which contributes to normal energy yielding metabolism and the normal function of the immune system Learn how your body responds to food 👉 zoe.com/podcast for 10% off Follow ZOE on Instagram. Timecodes 00:00 Introduction 01:01 Quickfire questions 03:51 What is obesity? 05:06 What’s the difference between overweight and obesity? 07:38 Why has there been such a quick rise in obesity? 10:55 Why it’s not just a lack of willpower 13:50 The complexity of weight regulation 15:54 What is Leptin and why is it so important for weight control? 19:51 The brain’s role in weight regulation 20:36 Curing obesity in animal studies 22:29 Why hunter-gatherers did not gain weight 23:58 Natural experiments in weight gain and loss 26:01 How medications can cause weight gain 28:42 The impact of calorie restriction diets 30:13 Reducing diabetes risk through weight loss 34:10 Research into medications as a tool for weight loss 38:36 How well do weight loss drugs work? 41:38 The future of weight loss drugs 43:51 Will you regain the weight if you stop taking weight loss drugs? 48:08 Can obesity be avoided without the use of drugs? 49:42 Concerns about weight loss drugs Books by our ZOE Scientists: Every Body Should Know This by Dr Federica Amati Food For Life by Prof. Tim Spector Fibre Fuelled by Dr Will Bulsiewicz Mentioned in today's episode: Persistent metabolic adaptation 6 years after "The Biggest Loser" competition in Obesity The Finnish diabetes prevention study (DPS) in Diabetes Care The National Diabetes Prevention Program of the Centers for Disease Control and Prevention (CDC) Have feedback or a topic you'd like us to cover? Let us know here. Episode transcripts are available here.
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    58 mins
  • Fix your body clock to improve long term health with Prof. Satchin Panda

    Fix your body clock to improve long term health with Prof. Satchin Panda
    Jun 20 2024
    Our modern lifestyles mean that most of us don’t live our lives in sync with our circadian rhythms, which puts our health and well-being at risk. Eating and sleeping at the right time are important tools to help us align our circadian rhythms and reduce our risk of chronic disease. In this episode, circadian rhythm expert Prof. Satchin Panda will tell us how light and food act as master regulators of our body clock, how aligning our lifestyles with our body clock can improve our health, mood and energy levels and how to do this in practice. Satchin is a world-leading expert in the field of circadian rhythm research. He’s associate professor at the prestigious SALK institute, he’s recipient of the Dana Foundation Award in brain and immune system imaging and he’s also the author of two best-selling books, The Circadian Code and The Circadian Diabetes Code. 🌱 Try our new plant based wholefood supplement - Daily 30 *Naturally high in copper which contributes to normal energy yielding metabolism and the normal function of the immune system Timecodes: 00:00 Introduction 01:00 Quickfire questions 03:02 What are circadian rhythms? 03:48 How do we know about circadian rhythms? 04:44 Are all body parts on a 24 hour clock? 06:40 How the body enters sleep mode 09:25 What happens during sleep? 12:08 Why you’re not sleeping enough 13:30 The surprising impact of daylight savings time 17:00 Circadian rhythms aren’t just about light 19:55 The dangers of shift work 21:20 Should you go to bed at sunset? 25:40 Why should stop snacking at night 26:10 Satchin’s famous mice study 33:00 The best eating window for health 37:27 Does intermittent fasting promote better food choices? 40:40 Should you drink black coffee when you wake up? Satchin’s books: The Circadian Code The Circadian Diabetes Code Books by our ZOE Scientists: Every Body Should Know This by Dr Federica Amati Food For Life by Prof. Tim Spector Fibre Fuelled by Dr Will Bulsiewicz Studies referenced in today’s episode: Effects of 3 months of 10-h per-day time-restricted eating and 3 months of follow-up on bodyweight and cardiometabolic health in Danish individuals at high risk of type 2 diabetes: the RESET single-centre, parallel, superiority, open-label, randomised controlled trial, published in Lancet Healthy Longevity Neuronal reprogramming of mouse and human fibroblasts using transcription factors involved in suprachiasmatic nucleus development, published iScience Learning from circadian rhythm to transform cancer prevention, prognosis, and survivorship care, published in Trends Cancer The Untapped Potential of Circadian Timing as a Variable for Discoveries and Reproducibility, published in Cell Mol Gastroenterol Hepato Follow ZOE on Instagram Have feedback or a topic you'd like us to cover? Let us know here. Episode transcripts are available here.
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    52 mins
  • Remembering Michael Mosley: 4 habits that changed his life

    Remembering Michael Mosley: 4 habits that changed his life
    Jun 13 2024
    After the tragic news of Michael Mosley's passing, we are re-releasing our episode with him, originally released in March 2023: If you had to do just one thing to improve your health, what would it be? Our busy lives mean it can be difficult to keep up healthy habits, and with so much conflicting advice out there it’s tricky to separate fact from fiction. In today’s episode, Jonathan is joined by medical doctor, journalist, and presenter Michael Mosley, who is alongside ZOE regular Tim Spector, to discuss Michael’s four key habits to improve our health. Michael’s latest book ‘Just One Thing’ explores these habits and has seen him speak to singing scientists and eccentric iceman to healthy habit experts and evangelists. And of course, being Michael, he tried every habit out himself. We talk about which methods are the most effective, which he has incorporated into his life, and how he makes his new habits stick. 🌱 Try our new plant based wholefood supplement - Daily 30 *Naturally high in copper which contributes to normal energy yielding metabolism and the normal function of the immune system If you want to uncover the right foods for your body, head to zoe.com/podcast and get 10% off your membership. Follow ZOE on Instagram Timecodes: 00:00 Tim Spector's tribute to Michael 01:01 Introduction 01:55 Quick Fire Questions 05:15 Are cold showers good for you? 06:48 How long do you need to be immersed in cold water for the benefits to work? 8:20 Can cold showers improve mental wellbeing? 11:30 Potential dangers of cold water swimming 12:45 Do cultural differences present different outcomes across the world? 13:58 Can these small stressors help us? 14:27 What is the theory behind this working? 16:15 Will this work for everyone or is this very personalized? 18:30 What effects does breathing have on your health? 19:55 How breathing exercises affect our brain 22:27 How do you keep up the breathing exercises? 23:27 ZOE app breathing exercise 25:40 Is there a difference between breathing through your nose and your mouth? 27:20 How important are plants and nature for our health? 30:25 Can exposure to nature improve things like mental health and even gut health? 32:00 Can herbs also help improve our health? 32:47 What are the benefits of exercise? 33:30 What are endo-cannibinoids? 34:41 Are preferences for exercise genetic? 36:12 Is it endorphins that make us feel good after / during exercise? 37:31 How exercise affects us is extremely personalized 39:42 How do we encourage people who don't enjoy exercise to do it? 41:13 Tips to improve your exercise routines 44:08 Are there benefits to walking downhill? 46:42 Summary Michael Mosley’s book 'Just One Thing' is available to buy here Episode transcripts are available here
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    51 mins
  • Is plant-based meat healthy? What the research shows with Prof. Christopher Gardner

    Is plant-based meat healthy? What the research shows with Prof. Christopher Gardner
    Jun 6 2024
    Meat consumption continues to be high in both the US and the UK. Yet many governments advise reducing meat consumption, particularly red meat, due to both environmental and health concerns. In this episode, we delve into the sizzling world of meat alternatives. They promise sustainability, animal welfare, and better health. Buzzwords like "plant-based" and "meat-free" proudly adorn their packaging. But are they actually healthy? Or should we consider them as ultra-processed foods and avoid them? Christopher Gardner is a Professor of Medicine at Stanford University and the Director of the Stanford Prevention Research Centre, and a world-leading expert in how the food that we eat impacts our health. 🌱 Try our new plant based wholefood supplement - Daily 30 *Naturally high in copper which contributes to normal energy yielding metabolism and the normal function of the immune system Learn how your body responds to food 👉 zoe.com/podcast for 10% off Follow ZOE on Instagram. Timecodes: 00:00 Introduction 01:25 Quickfire questions 03:50 What is a meat alternative? 05:22 What's driving the trend for more alternatives? 07:47 Should you eat less red meat? 08:38 What is in meat alternatives? 10:22 Traditional meats vs meat alternatives 13:41 Are meat alternatives ultra-processed? 14:47 Latest scientific studies 23:56 What were the findings? 29:48 Is the quality of the protein as good as real meat? 34:00 Are meat alternatives healthy? 38:53 Are whole food based meat alternatives healthier? 40:05 What are the practical tips around meat alternatives? 43:21 How do ultra-processed foods come into this? 45:23 What are other ways people can transition away from red meat? 50:33 What are the differences between bad and good quality meat? 📚 Books from our ZOE Scientists: Every Body Should Know This by Dr Federica Amati Food For Life by Prof. Tim Spector Fibre Fuelled by Dr Will Bulsiewicz Studies referenced in today’s episode: Study With Appetizing Plantfood—Meat Eating Alternative Trial (SWAP-MEAT), published in American Journal of Clinical Nutrition. SWAP-MEAT Athlete (study with appetizing plant-food, meat eating alternatives trial) a randomized crossover trial, published in Nutrition Journal. Have feedback or a topic you'd like us to cover? Let us know here. Episode transcripts are available here.
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    1 hr and 2 mins
  • Menstruation: Science, medicine and mythology

    Menstruation: Science, medicine and mythology
    May 30 2024
    Periods are taboo! Despite the fact that half of the world’s population experience them. This taboo has led to countless myths around the topic. “The internet’s gynecologist” Dr. Jen Gunter is here to usher in a new era where people understand – and can advocate for – what they need as their body changes each cycle. Jonathan is joined by Dr Sarah Berry and Dr Jen Gunter to get a better understanding of our body's behavior during the menstrual cycle. Jen will provide you with her period toolkit and offer solutions to the most common problems of modern-day period health. Dr. Jen Gunter is a gynecologist and pain medicine physician at the Permanente Medical Group in northern California. Her books ‘The Vagina Bible’ and ‘The Menopause Manifesto’ were both New York Times bestsellers. Her 2024 book ‘Blood’ tackles the science, medicine and mythology of menstruation. 🌱 Try our new plant based wholefood supplement - Daily 30 *Naturally high in copper which contributes to normal energy yielding metabolism and the normal function of the immune system Learn how your body responds to food 👉 zoe.com/podcast for 10% off Follow ZOE on Instagram. Timecodes: 00:00 Introduction 01:26 Quickfire questions 02:31 Shame culture around menstruation 04:20 The evolution and purpose of the menstrual cycle 06:30 Menstrual cycle mechanics 11:08 Understanding heavy periods and iron deficiency 14:01 Addressing period pain and discomfort 21:39 Diet, appetite, and periods: what's the connection? 26:09 Understanding PMS and PMDD 27:55 PMS causes and symptoms 30:52 Treatment options for PMS and PMDD 31:51 Demystifying polycystic ovarian syndrome (PCOS) 35:42 The role of diet and obesity in PCOS 37:32 Advice for managing PMS 40:19 Menstrual cramps and pain management 47:08 Iron supplementation strategies 📚 Dr. Jen Gunter’s books: The Menopause Manifesto Blood: The Science, Medicine, and Mythology of Menstruation 📚 Books from our ZOE Scientists: Every Body Should Know This by Dr Federica Amati Recipes for a Better Menopause by Dr Federica Amati Food For Life by Prof. Tim Spector Studies related to today’s episode: Prevalence of Iron Deficiency and Iron-Deficiency Anemia in US Females Aged 12-21 Years, 2003-2020, from the Journal of the American Medical Association The Role of Estrogen in Insulin Resistance: A Review of Clinical and Preclinical Data, from The American Journal of Pathology Have feedback or a topic you'd like us to cover? Let us know here Episode transcripts are available here.
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    57 mins
  • Why dementia could start in your blood vessels with Dr. William Li

    Why dementia could start in your blood vessels with Dr. William Li
    May 23 2024
    55 million people suffer dementia worldwide with numbers expected to double every 20 years. Understanding the link between our heart health and brain function is critical, illuminating the profound impact that heart health has on preventing dementia. Dr. William Li, an expert in cardiovascular and metabolic health. He reveals how caring for our heart is not just about longevity but maintaining sharp, effective brain function as we age. His groundbreaking work has impacted more than seventy diseases including diabetes, heart disease, and obesity. Dr. Li is also a New York Times best-selling author. In today’s episode, Dr. Li explains how simple lifestyle choices in diet, exercise and sleep can drastically shape our brain's health and stave off dementia. 🌱 Try our new plant based wholefood supplement - Daily 30 *Naturally high in copper which contributes to normal energy yielding metabolism and the normal function of the immune system If you want to uncover the right foods for your body, 👉 zoe.com/podcast, for 10% off your membership. Follow ZOE on Instagram Timecodes 00:00 Introduction 01:23 Quickfire questions 03:30 Understanding dementia and Alzheimer's disease 04:50 Dementia versus ageing 06:35 The role of blood vessels in brain health 07:55 How circulation affects brain function 09:23 What causes blood clots and strokes? 11:06 The importance of maintaining healthy blood vessels 12:15 The impact of lifestyle choices on brain health 15:01 What happens in our brains when we sleep? 19:35 What is the glymphatic system? 22:40 Vascular dementia may be the most common form of dementia 24:35 The role of glucose in brain function 27:10 What causes dementia and why does it happen when we get older? 29:00 Preventing dementia with lifestyle changes 31:10 What are healthy blood vessels like? 37:50 The surprising role of EPCs in brain repair 41:30 Can you slow down or reverse dementia? 52:08 The connection between gut health and brain health 51:40 The importance of exercise for brain health 56:30 How to avoid dementia 01:01:16 The link between mental health and cardiovascular disease 📚 Dr. William Li’s books: Eat to Beat Disease Eat to Beat Your Diet 📚 Books from our ZOE Scientists: Every Body Should Know This by Dr Federica Amati Food For Life by Prof. Tim Spector Relevant studies: A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk, published in Nature Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images, published in Science Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study—a randomized controlled trial, published in The American Journal of Clinical Nutrition Have feedback or a topic you'd like us to cover? Let us know here Episode transcripts are available here.
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    1 hr and 15 mins
  • How inflammation could age you with Prof. Philip Calder

    How inflammation could age you with Prof. Philip Calder
    May 16 2024
    Inflammation is a complicated topic. Short-term inflammation plays an essential role in fighting infections and healing injuries. But too much inflammation can be a catalyst for chronic ailments, like heart disease, type 2 diabetes, autoimmune disorders, rheumatoid arthritis, and obesity. What we eat can influence our inflammatory responses and contribute to chronic, low-grade inflammation. In today’s episode, Prof. Philip Calder helps us understand the science behind inflammation, how it impacts our health and what food has to do with it. Philip is head of the School of Human Development and Health, as well as a Professor of Nutritional Immunology, in the Faculty of Medicine at the University of Southampton. He’s also an internationally recognised researcher on the metabolism and functionality of fatty acids. His work focuses on the roles of omega-3 fatty acids and the influence of diet and nutrients on immune and inflammatory responses. 🌱 Try our new plant based wholefood supplement - Daily 30 *Naturally high in copper which contributes to normal energy yielding metabolism and the normal function of the immune system Learn how your body responds to food 👉 zoe.com/podcast for 10% off Follow ZOE on Instagram. Timecodes 00:00 Introduction 01:20 Quickfire questions 02:55 The role of inflammation in immunity 05:30 Chronic inflammation and disease 08:30 How to measure inflammation 09:53 Low-grade inflammation and disease risk 12:30 What causes blood vessel inflammation? 15:23 What creates the narrowing of blood vessels? 17:20 How inflammation can cause blood clots, heart attacks and strokes 19:15 Inflammation and aging 21:40 Inflammation and lifestyle factors 25:07 Obesity and inflammation 28:45 Muscle loss and inflammation (sarcopenia) 30:52 The impact of meals, sugar and fats on inflammation 33:35 How diet could reduce inflammation 34:42 Why we all respond to food differently 38:42 Dietary choices to manage inflammation 40:00 What are omega-3s? 41:17 Anti-inflammatory foods 43:40 Health benefits of omega-3 fatty acids 45:55 Challenges with farmed salmon 📚 Books from our ZOE Scientists: Every Body Should Know This by Dr Federica Amati Food For Life by Prof. Tim Spector Mentioned in today's episode: Omega-3 polyunsaturated fatty acids and inflammatory processes: Nutrition or pharmacology? in the British Journal of Clinical Pharmacology Omega-6 fatty acids and inflammation in PLEFA Omega-3 fatty acids and inflammatory processes in Nutrients Another relevant study: Health relevance of the modification of low-grade inflammation in ageing and the role of nutrition in Ageing Research Reviews Have feedback or a topic you'd like us to cover? Let us know here Episode transcripts are available here.
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    1 hr and 3 mins
  • Your new menopause toolkit with Dr. Mary Claire Haver & Dr. Sarah Berry

    Your new menopause toolkit with Dr. Mary Claire Haver & Dr. Sarah Berry
    May 9 2024
    The menopause transition can bring unexpected challenges — the effects can significantly impact daily life and long-term health. Dr. Mary Claire Haver is a board-certified gynaecologist and a menopause specialist. She's helped thousands of women in perimenopause and menopause to realise their health goals. In today’s episode, she joins Jonathan and ZOE's Chief Scientist Dr. Sarah Berry to shed light on what to expect during these life stages. Sarah and Mary Claire describe practical strategies for managing symptoms, critical conversations to have with healthcare providers, and how to advocate for yourself effectively in medical settings. 🌱 Try our new plant based wholefood supplement - Daily 30 *Naturally high in copper which contributes to normal energy yielding metabolism and the normal function of the immune system Learn how your body responds to food 👉 zoe.com/podcast for 10% off Follow ZOE on Instagram. Timecodes: 00:00 Introduction 01:33 Quickfire questions 05:53 There is a lack of menopause training in medical school 07:02 Most women are going into menopause blind 07:43 Why menopause symptoms vary 09:30 The hormonal ‘zone of chaos’ 11:45 ZOE PREDICT data on menopause symptoms 13:36 How long do perimenopause symptoms last? 17:52 Perimenopause at age 35? 18:34 Why hormone tests are worthless 20:53 The risk of chronic disease after menopause 24:53 Why does menopause increase hunger? 28:39 Why medicine and research is male-dominated 32:34 How to talk to your doctor about menopaue 34:12 Pregnancy research - 10x more extensive than menopause research! 35:14 Mary Claire’s toolkit of strategies for menopause 36:34 What are the long-term health benefits of hormone replacement therapy? 38:36 Is HRT safe for most women? 42:47 Brand new ZOE study results: diet and menopause 49:16 Top 3 tips to help with symptoms 54:34 What is ‘frozen shoulder’ and how can you treat it? 📚 Mary Claire's book The New Menopause 📚 Books from our ZOE Scientists Every Body Should Know This by Dr Federica Amati Food For Life by Prof. Tim Spector Mentioned in today's episode Menopause transition and cardiovascular disease risk: Implications for timing of early prevention: A scientific statement from the American Heart Association in Circulation The controversial history of hormone replacement therapy in Medicina Dr. Vonda Wright’s website Have feedback or a topic you'd like us to cover? Let us know here Episode transcripts are available here.
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    1 hr and 10 mins