In this episode of FYI, Brett Winton, ARK's Chief Futurist, and Nemo Marjanovic, ARK's Multiomics Analyst, have an in-depth discussion with Professor Nikolai Slavov from Northeastern University. Professor Slalov is the Director of Parallel Squared Technology Institute (PTI). Together they explore the fascinating and complex world of multiomics, focusing on the importance of proteomics in understanding biological processes. Professor Slavov shares his insights on the technological advancements in single-cell proteomics, the challenges in measuring protein interactions, and the critical role of proteomics in drug development. The conversation also delves into the underfunded nature of proteomics research and its potential to revolutionize biopharma R&D and diagnostics.

• Introduction to multi-omics and its relevance in modern biology.
• Explanation of the central dogma of molecular biology: DNA, RNA, and proteins.
• Overview of Professor Slavov's research on single-cell proteomics and its implications.
• Challenges in measuring the dynamic and complex nature of the proteome.
• The role of advanced technologies like mass spectrometry in proteomic analysis.
• Importance of protein interactions and modifications in cellular functions.
• Discussion on the underfunding of proteomics research and its impact on scientific progress.
• The potential of proteomics to improve drug development and diagnostic precision.
• Advances in AI and data analysis techniques for better understanding protein structures and functions.
• Future frontiers in proteomics, including improved technology access and dynamic protein measurements.

MacCoss, M.J., Alfaro, J.A., Faivre, D.A. et al. Sampling the proteome by emerging single-molecule and mass spectrometry methods. Nat Methods 20, 339–346 (2023). https://doi.org/10.1038/s41592-023-01802-5

Derks J, Jonson T, Leduc A, Khan S, Khoury L, Rafiee M, Slavov N Single-nucleus proteomics identifies regulators of protein transport

bioRxiv doi: 10.1101/2024.06.17.599449 (2024)