Episodes

  • TWiV 1155: Spillover in stall A

    TWiV 1155: Spillover in stall A
    Oct 6 2024

    TWiV reviews mask effectiveness against respiratory infections, EEE death in NY State, viruses with zoonotic potential in farmed fur animals, and genetic tracing of market wild life and viruses at the Huanan Seafood Market, the epicenter of the COVID-19 pandemic.

    Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiV!

    Links for this episode
    • MicrobeTV Discord Server
    • Review confirms mask effectiveness (original article)
    • EEE death in Ulster County NY (CBS News)
    • EEE on TWiV 1145
    • Viruses of farmed fur animals (Nature)
    • Tracing of wildlife and viruses at COVID-19 epicenter (Cell)
    • Letters read on TWiV 1155
    • Timestamps by Jolene. Thanks!
    Weekly Picks

    Rich – Immunize.org, Vaccineinformation.org, National Network of Immunization Coalitions
    Alan – Birdcast
    Vincent – A universal framework for inclusive 15-minute cities

    Intro music is by Ronald Jenkees

    Send your virology questions and comments to twiv@microbe.tv

    Content in this podcast should not be construed as medical advice.
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    1 hr and 35 mins
  • TWiV 1154: Clinical update with Dr. Daniel Griffin

    TWiV 1154: Clinical update with Dr. Daniel Griffin
    Oct 5 2024
    In his weekly clinical update, Dr. Griffin discusses the Marburg virus outbreak in Rwanda, the lack of immune durability following pertussis vaccination, recommendations for maternal vaccination and antibody therapy to protect against infant RSV, vaccine security for Mpox, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how to put on and take off PPE to avoid contamination, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, the lack of immune durability elicited by mRNA vaccine and the finding of how SARS-CoV-2 infection impacts memory, cognition and reduces grey matter volume. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Rwanda: Marburg virus disease (WHO)Passport required?…..Marburg virus commutes to Germany (CIDRAP)Outbreak of whooping cough/pertussis…..no lifelong immunity following vaccination? (BloombergProtection of infants by maternal antibodies against RSV by either vaccination or nirsevimab (MMWR)WHO recommendations for RSV: maternal vaccination and antibody shot (Reuters) Ziresovir for RSV hospitalized infants (NEJM)Crawling to effective anti-RSV countermeasures (NEJM)The $800 million pledge for African mpox response (Reuters)COVID-19 deaths (CDC)COVID-19 national and regional trends (CDC)Waste water scan for 11 pathogens (WastewaterSCan)COVID-19 variant tracker (CDC)SARS-CoV-2 genomes galore (Nextstrain) Doffing your PPE– contact precautions (CID)mRNA vaccination does not elicit durable immune response (Nature Medicine) IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA)Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) CDC Quarantine guidelines (CDC)NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society)Drug interaction checker (University of Liverpool)Molnupiravir safety and efficacy (JMV)Convalescent plasma recommendation for immunocompromised (ID Society)What to do when sick with a respiratory virus (CDC)When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)Managing healthcare staffing shortages (CDC)Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org)Mechanisms of long COVID and therapeutics (Cell)Post hospitalization cognitive deficits and grey matter reduction 1 year after COVID-19 (Nature Medicine)Letters read on TWiV 1154Dr. Griffin’s COVID treatment summary (pdf)Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
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    39 mins
  • TWiV 1153: Viruses that (can) make you well

    TWiV 1153: Viruses that (can) make you well
    Sep 29 2024

    From the Viruses of Microbes meeting in Cairns, Australia, TWiV speaks with Krystyna and Rob about their research on using bacteriophages to treat bacterial infections.

    Hosts: Vincent Racaniello and Jolene Ramsey

    Guests: Krystyna Dabrowska and Rob Lavigne

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiV!

    Links for this episode
    • MicrobeTV Discord Server
    • Viruses of Microbes 2024
    • Immune responses to phages (Front Immunol)
    • Engineering bacteriolytic enzymes (Front Immunol)
    • 100 cases of phage therapy (Nat Micro)
    • Synthetic biology potential of bacteriophages (Nat Micro)
    • Timestamps by Jolene. Thanks!

    Intro music is by Ronald Jenkees

    Send your virology questions and comments to twiv@microbe.tv

    Content in this podcast should not be construed as medical advice.
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    55 mins
  • TWiV 1152: Clinical update with Dr. Daniel Griffin

    TWiV 1152: Clinical update with Dr. Daniel Griffin
    Sep 28 2024
    In his weekly clinical update, Dr. Griffin deep dives into the durability of the antibody response following mpox vaccination, vaccine security, global mpox circulation, the origins of SARS-CoV-2, including a list TWiV episodes and combatting scientific misinformation, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if remdesivir + dexamethasone lowers mortality of hospitalized COVID-19 patients and the finding of how SARS-CoV-2 infection impacts memory and cognition. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Waning vaccine protection against mpox…..isn’t this the way the humoral immune response works? (CIDRAP) 1:46Uncontrollable mpox outbreak in Africa (Reuters) 4:10Antibodies elicited by the Jynneos vaccine against mpox contract after 6-9 months….can you believe? (medrxiv) 4:45Mpox vaccine for adolescents approved (Pharmaceutical Technology) 14:05 Clade 1b mpox visiting India (CIDRAP) 15:05 Mpox clade 1b in Kerala (ANI South Asia’s Leading Multimedia News Agency) 15:13US government orders $63M worth of small pox/mpox vaccine (Reuters) 15:34Mpox donations boosting global supply (US Department of Health and Human Services)1 million mpox vaccine doses for Africa….with love from US government (CIDRAP) 15:55 Speed doses of mpox vaccine (CIDRAP)Mpox vaccine donations (UNICEF) 17:35 Bavarian Nordic mpox vaccine (Yahoo finances)Early epicenter of COVID-19 pandemic Huanan seafood market (Science) 23:07Wildlife trade likely source of SARS-CoV-2 (Science) 23:16Zoonotic origins of SARS-CoV-2 (Science) 23:20Surveillance at the Huanan Seafood market (Europe PMC) 25:03TWiV shout outs…..all for the SARS-CoV-2 spill over from nature 25:31 TWiV 1019: Eddie Holmes on SARS-CoV-2 originsTWiV 1017: From Nature, not a labTWiV 995: Viral origin storiesTWiV 940: Eddie Holmes in on viral originsTWiV 876: Spillover market with Michael WorobeyTWiV 762: SARS-CoV-2 origins with Robert GarryTWiV 760: SARS-CoV-2 origins with Peter Daszak, Thea Kølsen Fischer, Marion KoopmansTWiV 774: Kristian Andersen, Robert Garry, and the deleted SARS-CoV-2 sequences Genetic tracing of market wildlife and viruses at Huanan Market (Cell) 18:56Combatting scientific misinformation (microbeTV: TWiV) 34:14COVID-19 deaths (CDC) 35:20COVID-19 national and regional trends (CDC)Waste water scan for 11 pathogens (WastewaterSCan)COVID-19 variant tracker (CDC)SARS-CoV-2 genomes galore (Nextstrain)Suggestion for the use of a new preventive COVID-19 agent (IDSA) IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA)Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) CDC Quarantine guidelines (CDC)NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society)Drug interaction checker (University of Liverpool)Molnupiravir outcomes 3 and 6 months after treatment (LANCET Infectious Diseases)Antivirals and post-COVID-19 conditions (LANCET Infectious Disease)Molnupiravir safety and efficacy (JMV)Convalescent plasma recommendation for immunocompromised (ID Society)What to do when sick with a respiratory virus (CDC)When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)Managing healthcare staffing shortages (CDC)Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org)Lower mortality risk associated with remdesivir + dexamethasone versus dexamethasone for hospitalized COVID-19 patients (CID) 39:17Changes in memory and cognition during the SARS-CoV-2 human challenge study (eClinical Medicine) 42:25Letters read on TWiV 1152 48:18Dr. Griffin's COVID treatment summary (pdf)Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
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    58 mins
  • TWiV 1151: Hotel California for Phage

    TWiV 1151: Hotel California for Phage
    Sep 22 2024

    TWiV reviews polio vaccination campaign in Gaza, viruses with zoonotic potential in farmed fur animals, low HPV vaccination in North Texas associated with high rates of cervical cancer, a large flavivirus genome that does not encode error correction machinery, and antiphage defense through inhibition of virion assembly.

    Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Jolene Ramsey

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiV!

    Links for this episode
    • MicrobeTV Discord Server
    • Polio vaccination in Gaza (Reuters)
    • Zoonotic viruses in farmed fur animals (Nature)
    • HPV vaccination and cancer rates (JAMA Net Open)
    • 40 kb RNA genome without error correction (PNAS)
    • Stopping the phage tape measure protein (Nat Commun)
    • Tail assembly interference (Nat Commun)
    • Letters read on TWiV 1151
    • Timestamps by Jolene. Thanks!
    Weekly Picks

    Dickson – Digital nature pics winners 2024 Wildlife Photographer of the Year
    Alan – Adorable story about a Nigerian paralympian couple who are both polio survivors
    Jolene – Capsid assembly model with self-assembling pentamers in 3D print model (plus three more models now available if search self assembling virus) and Wonderlab article about exhibit using this to teach about viral patterns in Bloomington Indiana Science museum
    Vincent – The collapse of bat populations led to more than a thousand infant deaths

    Intro music is by Ronald Jenkees

    Send your virology questions and comments to twiv@microbe.tv

    Content in this podcast should not be construed as medical advice.
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    1 hr and 44 mins
  • TWiV 1150: Clinical update with Dr. Daniel Griffin

    TWiV 1150: Clinical update with Dr. Daniel Griffin
    Sep 21 2024
    In his weekly clinical update, Dr. Griffin dives into West Nile virus in New Jersey, poliovirus vaccination campaign in Gaza and Afghanistan, California dengue virus infections, children dying from flu, mpox vaccination procurement and antiviral usage, flu circulation in US, before reviewing the recent statistics on SARS-CoV-2 infection, finding a new wasterwater dashboard, if the monovalent XBB.1.5 COVID-19 vaccine is effective against circulating SARS-CoV-2 isolates, the need for nasal mucosal IgA in response to SARS-CoV-2 infection, where to find PEMGARDA, does administration of molnupiravir reduce symptoms in the vaccinated, when to use convalescent plasma, how molnupiravir treatment leads to better outcomes 3 and 6 months after treatment, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, and if those taking the anti-diabetic drug metformin have higher or lower incidences of long COVID. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode West Nile virus in New Jersey (CBSNews)Poliovirus vaccination 90% coverate (Reuters) Suspension of poliovirus eradication by the Taliban (apnews)California dengue cluster (CIDRAP) Children dying of influenza (CIDRAP) 199 children deaths from flu (CDC)Bavarian Nordic mpox vaccine (Yahoo finances) Prequalification of MVA-BN mpox vaccine (WHO Int) Speed doses of mpox vaccine (CIDRAP)GAVI rapidly secures 500K doses of mpox vaccines for Africa(GAVI)Expanded access to teconvirimat for mpox treatment in US 2022-2023(NEJM Evidence) FluView (CDC) Human to human transmission of bird flu in Missouri? (NY Times)Bird flu isolated from humans in Missouri similar to that found in cattle (CNN)COVID-19 deaths (CDC)COVID-19 national and regional trends (CDC)Waste water scan for 11 pathogens (WastewaterSCan)COVID-19 variant tracker (CDC)SARS-CoV-2 genomes galore (Nextstrain)Effectiveness of Updated 2023–2024 (Monovalent XBB.1.5) COVID-19 Vaccination Against SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 Lineage (CID)Early, robust mucosal secretory IgA but not IgG response to SARS-CoV-2 spike in oral fluid is associated with faster viral clearance and COVID-19 symptom resolution (JID)Suggestion for the use of a new preventive COVID-19 agent (IDSA) IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA)Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) CDC Quarantine guidelines (CDC)NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society)Drug interaction checker (University of Lierpool)Molnupiravir outcomes 3 and 6 months after treatment (LANCET Infectious Diseases)Antivirals and post-COVID-19 conditions (LANCET Infectious Disease)Molnupiravir safety and efficacy (JMV)Convalescent plasma recommendation for immunocompromised (ID Society)What to do when sick with a respiratory virus (CDC)When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)Managing healthcare staffing shortages (CDC)Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Metformin use in adults with diabetes and incidence of long COVID (Diabetes Care)Letters read on TWiV 1150Dr. Griffin’s COVID treatment summary (pdf)Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
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    48 mins
  • TWiV 1149: Mary Estes, a gutsy virologist

    TWiV 1149: Mary Estes, a gutsy virologist
    Sep 15 2024

    From the annual meeting of the American Society for Virology, Kathy and Brianne speak with Mary Estes about her career and the research of her laboratory on viruses that infect the gastrointestinal tract, including rotavirus and norovirus.

    Hosts: Kathy Spindler and Brianne Barker

    Guest: Mary Estes

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiV!

    Links for this episode
    • MicrobeTV Discord Server
    • Diarrhea induced by rotavirus NSP4 (Science)
    • Minimal infective dose of rotavirus (Arch Virol)
    • mRNA release from rotavirus particles (Nat Struct Biol)
    • Norovirus vaccine (Clin Ther)
    • Timestamps by Jolene. Thanks!

    Intro music is by Ronald Jenkees

    Send your virology questions and comments to twiv@microbe.tv

    Content in this podcast should not be construed as medical advice.
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    1 hr and 5 mins
  • TWiV 1148: Clinical update with Dr. Daniel Griffin

    TWiV 1148: Clinical update with Dr. Daniel Griffin
    Sep 14 2024
    In his weekly clinical update, Dr. Griffin dives into “pandemic potential” viruses isolated from farmed fur animals, how the mRNA and pox vectored vaccines against mpox spar against each other, how telehealth does managing mpox, and if prophylactic use of the anti-RSV monoclonal for infants is cost-effective before reviewing the recent statistics on SARS-CoV-2 infection, if viral load correlates to one vaccination status, where to find PEMGARDA, does administration of molnupiravir reduce symptoms in the vaccinated, when to use convalescent plasma, how molnupiravirs treatment leads to better outcomes 3 and 6 months after treatment, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, and if SARS-CoV-2 during Omicron alters ones’ micriobiota. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Lending you the viruses in my fur (Nature) mRNA or vaccinia based mpox vaccine (Cell)Virtual outpatient management of mpox (OFID)NYC: mpox vaccination finder (NYC)Vaccine, mpox/COVID-19 near you (NYC)Expensive or not expensive anti-RSV monoclonal therapy for infants (American Academy of Pediatrics)COVID-19 deaths (CDC)COVID-19 national and regional trends (CDC)COVID-19 variant tracker (CDC)SARS-CoV-2 genomes galore (Nextstrain)Association of vaccination and SARS-CoV-2 viral load phase 3 (JID) IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA)Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)Early phase of SARs-CoV-2 infection (COVID.gov) CDC Quarantine guidelines (CDC)NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society)Drug interaction checker (University of Liverpool)Molnupiravir outcomes 3 and 6 months after treatment (LANCET Infectious Diseases)Antivirals and post-COVID-19 conditions (LANCET Infectious Disease)Molnupiravir safety and efficacy (JMV)Convalescent plasma recommendation for immunocompromised (ID Society)What to do when sick with a respiratory virus (CDC)When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)Managing healthcare staffing shortages (CDC)Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org)Long COVID following infection with Omicron: oral microbiota changes(American Journal of Medicine)Letters read on TWiV 1148Dr. Griffin’s COVID treatment summary (pdf)Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
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    45 mins