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In this special episode of The Drive, Peter joins a unique conversation inspired by his daughter’s volunteer experience at a senior care center, where she formed meaningful relationships with residents curious about healthspan, lifespan, and strategies for living well as they age. Peter engages directly with the residents, covering critical topics like the profound impact of exercise—particularly strength training— for maintaining mobility, preventing falls, and preserving independence later in life. He also discusses the importance of nutrition, emphasizing adequate protein intake, along with strategies for sleep optimization and preservation of brain health. Peter also underscores the importance of emotional wellness, purpose, and social connections in healthy aging, provides advice on staving off chronic disease, and much more.

We discuss:

• Peter’s definition of longevity [2:30];
• Why it’s never too late to invest in your longevity [5:30];
• The importance of adding “life to years” rather than just “years to life” [7:45];
• The "four horsemen"—heart disease, cancer, neurodegenerative diseases, and metabolic conditions [9:15];
• Advice for those managing chronic diseases later in life [11:30];
• Why balance declines and falls become increasingly common with age, and how to prevent them [13:30];
• Why strength training is essential (and effective) for older adults [18:30];
• The five tools in Peter’s longevity toolkit [21:00];
• Practical ways older adults can safely begin exercising despite physical limitations or health issues [23:00];
• Principles of good nutrition, and the importance of adequate protein intake [24:00];
• The importance of sleep for cognitive health, and effective sleep-improvement strategies for seniors [27:30];
• How emotional health, social connections, and a sense of purpose significantly impact quality of life and longevity [32:00];
• Why Peter decided to focus his work on longevity [33:45];
• Protein intake recommendations should be based on ideal body weight (not current weight) [34:45];
• The potential of klotho as a therapy for improving cognitive function and combating aging-related cognitive decline [35:30];
• The best types of protein supplements to consider [36:45];
• The APOE gene's influence on Alzheimer's disease risk, and why everyone should proactively address brain health, regardless of genetics [38:15];
• How falls can accelerate cognitive decline, and the importance of staying physically and mentally active [40:45]; and More.

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Ashley Mason is a clinical psychologist and an associate professor at UCSF, where she leads the Sleep, Eating, and Affect (SEA) Laboratory. In this episode, Ashley provides a masterclass on cognitive behavioral therapy for insomnia (CBT-I), detailing techniques like time in bed restriction, stimulus control, and cognitive restructuring to improve sleep. She explains how to manage racing thoughts and anxiety, optimize sleep environments, and use practical tools like sleep diaries to track progress. She also offers detailed guidance on sleep hygiene; explores the impact of temperature regulation, blue light exposure, and bedtime routines; and offers guidance on finding a CBT-I therapist, along with sharing practical steps you can take on your own before seeking professional help.

We discuss:

• Defining insomnia: diagnosis, prevalence, and misconceptions [3:00];
• How insomnia develops, and breaking the cycle with cognitive behavioral therapy for insomnia (CBT-I) [7:45];
• The different types of insomnia, and the impact of anxiety, hydration, temperature, and more on sleep [11:45];
• The core principles of cognitive behavioral therapy (CBT) and how CBT-I is used to treat insomnia [20:00];
• Implementing CBT-I: time in bed restriction, sleep scheduling, and the effect of napping [29:45];
• Navigating family and partner sleep schedules, falling asleep on the couch, sleep chronotypes, and more [39:45];
• Key aspects of sleep hygiene: temperature, light exposure, and circadian rhythm disruptions [44:45];
• Blue light and mental stimulation before bed, and the utility of A-B testing sleep habits [52:45];
• Other simple interventions that may improve sleep [57:30];
• Ashley’s view on relaxation techniques and mindfulness-based practices [1:02:30];
• The effectiveness of CBT-I, the role of sleep trackers, and best practices for managing nighttime awakenings [1:04:15];
• Guidance on intake of food and alcohol for good sleep [1:16:30];
• Reframing thoughts and nighttime anxiety to reduce sleep disruptions [1:18:45];
• Ashley’s take on sleep supplements like melatonin [1:21:45];
• How to safely taper off sleep medications like benzos and Ambien [1:26:00];
• Sleep problems that need to be addressed before CBT-I can be implemented [1:38:30];
• The importance of prioritizing a consistent wake-up time over a fixed bedtime for better sleep regulation [1:40:15];
• Process S and Process C: the science of sleep pressure and circadian rhythms [1:45:15];
• How exercise too close to bedtime may impact sleep [1:47:45];
• The structure and variability of CBT-I, Ashley’s approach, and tips for finding a therapist [1:50:30];
• The effect of sauna and cold plunge before bed on sleep quality [1:56:00];
• Key takeaways on CBT-I, and why no one should have to suffer from insomnia [1:58:15]; and
• More.

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In this "Ask Me Anything" (AMA) episode, Peter explores the complex world of supplements by introducing a practical framework for evaluating their effectiveness and relevance to individual health needs. Rather than providing a simple list of recommendations, Peter aims to equip listeners with the tools to critically assess supplements on their own. He then applies this framework to discuss research on several popular supplements, including creatine, fish oil, vitamin D, B vitamins, and ashwagandha. Additionally, he covers key factors in assessing supplement quality, helping listeners develop a deeper understanding of how to make informed decisions based on their personal health goals.

If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #69 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.

We discuss:

• Overview of episode topics [1:45];
• How Peter evaluates patients’ supplement regimens, and common misconceptions about supplements vs. pharmaceuticals [3:00];
• A framework for evaluating supplements [6:15];
• Evaluating creatine: purpose of supplementation, dosing, and mechanism of action [10:00];
• Creatine: proven benefits for muscle performance, potential cognitive benefits, and why women may benefit more [15:15];
• Creatine: risk vs. reward, kidney concerns, and choosing the right supplement [18:45];
• Evaluating fish oil: its primary purpose as a supplement and how to track levels [20:45];
• Fish oil: how omega-3s impact inflammation, heart health, and brain function, and the strengths and limitations of current research [26:30];
• Fish oil: the risks of supplementation, guidance on selecting high-quality products, and how to determine whether supplementation is appropriate [37:30];
• Evaluating vitamin D: understanding deficiency and optimal levels [45:15];
• Vitamin D: role in bone health, immune function, potential longevity impact, and biomarker limitations [51:15];
• Vitamin D: efficacy, safety, and balancing risk vs. reward [58:15];
• Evaluating B vitamins: function, consequences of deficiency, and key biomarkers to assess whether supplementation is necessary [1:02:15];
• B vitamins: risks for CVD and dementia associated with deficiency, and limited evidence for general population supplementation [1:07:15];
• Evaluating ashwagandha: background, uses, and mechanism of action [1:15:30];
• Ashwagandha: current evidence for its effects on sleep, stress, and anxiety [1:19:15];
• Ashwagandha: evaluating supplement quality, safety profile, and the risk-reward balance [1:22:15];
• The importance of using a structured evaluation framework to assess any supplement [1:26:30]; and
• More.

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