• S2 Episode 1: Anticipating and Managing Drug Interactions: Pharmacokinetics of Long-Acting HIV Treatment and Prevention Formulations

  • Apr 11 2023
  • Length: 24 mins
  • Podcast

S2 Episode 1: Anticipating and Managing Drug Interactions: Pharmacokinetics of Long-Acting HIV Treatment and Prevention Formulations

  • Summary

  • Drs Michael S. Saag and Charles W. Flexner discuss the mechanisms of drug-drug interactions and the promise and limitations of longer-acting HIV therapeutics for both treatment and prevention.

    Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/986504). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

    Resources

    HIV Infection and AIDS https://emedicine.medscape.com/article/211316-overview

    Drug Interactions With Antiretroviral Therapy (ART) https://emedicine.medscape.com/article/2039809-overview

    Common Drug Interactions With Protease Inhibitors https://emedicine.medscape.com/article/2041624-overview

    HIV-Protease Inhibitors https://pubmed.ncbi.nlm.nih.gov/9562584/

    The Role of Drug Metabolizing Enzymes in Clearance https://pubmed.ncbi.nlm.nih.gov/24392841/

    AIDS Clinical Trials Group https://actgnetwork.org/

    Ritonavir https://reference.medscape.com/drug/norvir-ritonavir-342627

    The Cytochrome P450 Isoenzyme and Some New Opportunities for the Prediction of Negative Drug Interaction In Vivo https://pubmed.ncbi.nlm.nih.gov/29780235/

    Boosting https://clinicalinfo.hiv.gov/en/glossary/boosting

    Cytochrome p450 Structure, Function and Clinical Significance: A Review https://pubmed.ncbi.nlm.nih.gov/28124606/

    Darunavir https://reference.medscape.com/drug/prezista-darunavir-342647

    Atazanavir https://reference.medscape.com/drug/reyataz-atazanavir-342608

    Tenofovir Disoproxil Fumarate https://clinicalinfo.hiv.gov/en/drugs/tenofovir-disoproxil-fumarate/patient

    The Structure and Mechanism of Drug Transporters https://pubmed.ncbi.nlm.nih.gov/34272696/

    Tenofovir Alafenamide (TAF) Clinical Pharmacology https://pubmed.ncbi.nlm.nih.gov/35146360/

    Prodrugs for Improved Drug Delivery: Lessons Learned From Recently Developed and Marketed Products https://pubmed.ncbi.nlm.nih.gov/33137942/

    Update on Drug-Drug Interaction at Organic Cation Transporters: Mechanisms, Clinical Impact, and Proposal for Advanced In Vitro Testing https://pubmed.ncbi.nlm.nih.gov/33896325/

    The Role of Organic Anion Transporting Polypeptides in Drug Absorption, Distribution, Excretion and Drug-Drug Interactions https://pubmed.ncbi.nlm.nih.gov/27783531/

    Creatinine Clearance https://pubmed.ncbi.nlm.nih.gov/31334948/

    Dolutegravir https://reference.medscape.com/drug/tivicay-tivicay-pd-dolutegravir-999861

    Cobicistat https://reference.medscape.com/drug/tybost-cobicistat-999845

    Paxlovid https://pubmed.ncbi.nlm.nih.gov/35138785/

    Interaction Between Ritonavir and Statins https://pubmed.ncbi.nlm.nih.gov/11959074/

    COVID-19 Drug Interactions https://www.covid19-druginteractions.org/checker

    Cabotegravir https://reference.medscape.com/drug/vocabria-apretude-cabotegravir-1000364

    Lenacapavir https://reference.medscape.com/drug/sunlenca-lenacapavir-4000240

    Inhibitors of the HIV-1 Capsid, a Target of Opportunity https://pubmed.ncbi.nlm.nih.gov/29782334/

    Flip-Flop Pharmacokinetics--Delivering a Reversal of Disposition: Challenges and Opportunities During Drug Development https://pubmed.ncbi.nlm.nih.gov/21837267/

    Polymeric Biomaterials for Medical Implants and Devices https://pubmed.ncbi.nlm.nih.gov/33465850/

    Microneedle Arrays Combined With Nanomedicine Approaches for Transdermal Delivery of Therapeutics https://pubmed.ncbi.nlm.nih.gov/33419118/

    Preexposure HIV Prophylaxis https://emedicine.medscape.com/article/2054869-overview

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