What are some common side effects of medications like Ozempic and Wegovy? From the front lines of healthcare, we explore adverse effects of these medications based on real-world visits to the emergency department. Learn about common side effects such as nausea, dehydration, and muscle wasting, as well as lesser-known risks like starvation ketosis and mood changes. Chapters 0:00 - Introduction to & GLP-1 RAs 0:48 - Nausea and Vomiting as Side Effects 1:52 - Dehydration Leading to Kidney Injury 3:11 - GLP-1 RAs & Starvation Ketosis 4:16 - Muscle Wasting on GLP-1 RAs 5:08 - Depression and Mood Changes 5:39 - Honorable Mention: Gastroparesis Video on Muscle Wasting & GLP-1 Receptor Agonists: https://youtu.be/Po2gC3zG0C8 Spotify Channel: https://podcasters.spotify.com/pod/show/sterlingmdphd/ Social & Website: Instagram - https://www.instagram.com/sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Apple Podcasts: https://apple.co/3y438C9 References & Show Notes: http://www.nicksterling.com/ This content is not medical advice, is for general information purposes only and does not constitute the practice of medicine or any other healthcare professional services. No doctor-patient relationship is formed. This content is not a substitute for medical evaluation or treatment and does not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit http://nicksterling.com/terms for full Terms of Use.

In this episode, we explore how ketamine, a dissociative anesthetic with a long history in medical use, is now being investigated for its rapid and sustained effects on depression, anxiety, and PTSD. We discuss its role in promoting neuroplasticity—rewiring the brain's structure to counteract stress-induced atrophy—and review the evidence from clinical trials, including a landmark 2023 meta-analysis. While ketamine shows promise in alleviating depressive symptoms and supporting neural growth, we also address its risks and the importance of professional oversight. Learn how this cutting-edge research is reshaping mental health treatment and what it means for the future of therapy. Spotify Channel: https://podcasters.spotify.com/pod/show/sterlingmdphd/#mentalhealth Social & Website: Instagram - https://www.instagram.com/sterlingmdphd X - https://x.com/sterlingmdphd Facebook - / sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Apple Podcasts: https://apple.co/3y438C9 References & Show Notes: http://www.nicksterling.com/ This content is not medical advice, is for general information purposes only, and does not constitute the practice of medicine or any other healthcare professional services. No doctor-patient relationship is formed. This content is not a substitute for medical evaluation or treatment and does not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use. Timestamps 00:00:00 - Depression Treatments and Challenges 00:00:20 - Brain Rewiring and Neuroplasticity 00:00:36 - Ketamine: A Rapid Neuroplasticity Tool 00:00:52 - Ketamine's Origins as an Anesthetic 00:01:28 - How Ketamine Works in the Brain 00:01:49 - Evidence of Ketamine's Effectiveness for Depression 00:03:04 - Human Trials and Clinical Findings 00:04:14 - Short-Term and Medium-Term Efficacy 00:04:31 - Exploring Ketamine for PTSD and Anxiety 00:05:54 - Brain Changes in Depression 00:08:50 - How Ketamine Reverses Brain Damage 00:10:02 - Ketamine's Neuroplasticity Mechanisms 00:12:11 - Risks and Side Effects of Ketamine Treatment 00:14:15 - Long-Term Concerns and Cognitive Impacts 00:15:05 - A Holistic Approach to Depression Management 00:15:22 - Thanks and Channel Support

In this episode, we talk about a recent study from Nature Aging that suggests aging may not progress in a straight line. Using data from thousands of biological measurements, researchers identified key ages—44 and 60—where changes in aging appear to accelerate. We review what this means for our understanding of aging, how it affects multiple systems in the body, and the potential implications for health and disease. We also discuss what this study tells us—and doesn’t tell us—about the biology of aging and how it could guide future research.

Social & Website:

Instagram - https://www.instagram.com/sterlingmdphd

Twitter - https://x.com/sterlingmdphd

Newsletter - http://eepurl.com/hQpdqT

Apple Podcasts: https://apple.co/3y438C9

References & Show Notes: http://www.nicksterling.com/

The content of this podcast is not medical advice, is for general information purposes only, and does not constitute the practice of medicine or any other healthcare professional services. No doctor-patient relationship is formed. The content of this podcast is not a substitute for medical evaluation or treatment and does not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.