In this episode, I had the pleasure of sitting down with Nicolas Verhoeven of Physionic. We focus our attention on metabolic health and, specifically, the energy-related, cellular, and nutritional mechanisms of insulin resistance. Nicolas reviews evidence pertaining to the reversal of insulin resistance and dietary clinical trials demonstrating remission of type 2 diabetes. Nicolas also highlights the synergistic effects of physical activity and dietary habits on insulin resistance, expanding our discussion into mitochondrial health. Finally, we explore importance of a nuanced conversation around autophagy and its role in health and disease prevention. Physionic on YouTube: https://www.youtube.com/@Physionic Chapters: 00:00:13 - Nicolas' Background & Inspiration 00:05:34 - Misconceptions about Carbs & Fat Intake 00:08:57 - Mechanisms of Insulin Resistance 00:18:34 - Reversing Insulin Resistance & Diabetes 00:23:08 - Measuring Insulin Resistance 00:24:20 - Continuous Glucose Monitoring (CGM) 00:30:25 - Insulin Resistance & Health 00:37:33 - Mitochondrial Dysfunction 00:49:14 - Mitochondrial Biogenesis 00:56:05 - Improving Mitochondrial Health 01:02:54 - Autophagy 01:07:28 - Closing Remarks Social & Website: Instagram - https://www.instagram.com/sterlingmdphd Twitter - https://twitter.com/sterlingmdphd Facebook - https://www.facebook.com/sterlingmdphd TikTok - https://www.tiktok.com/@sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Subscribe to the Podcast: Apple Podcasts: https://apple.co/3y438C9 Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c Google Podcasts: https://bit.ly/3Olanei References & Show Notes: http://www.nicksterling.com/ The content of this podcast is not medical advice, is for general information purposes only, and does not constitute the practice of medicine or any other healthcare professional services. No doctor-patient relationship is formed. The content of this podcast is not a substitute for medical evaluation or treatment and does not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.

In this episode, we discuss polarized training, which includes high-volume low intensity training and high-intensity training. We review the scientific literature pertaining to endurance performance, mechanisms of recovery debt, adaptations to various exercise modalities, and developing training programs around polarized training.

MAF-180: https://philmaffetone.com/180-formula/

#ultra #ironman #endurance #fitness #marathon

Chapters:

00:00 - Intro

01:20 - Athletic Burnout

02:36 - Endurance Training Distributions

03:37 - Recovery Debt

04:06 - Exercise-Induced Cardiac Fatigue

04:34 - Nervous System Fatigue

05:33 - Muscle Microtrauma

07:01 - Fitness Adaptations

08:56 - Maximum Aerobic Heart Rate

10:30 - Lactate Threshold

11:04 - High Intensity Exercise

11:57 - Polarized Training Program

13:05 - Outro

Social & Website:

Newsletter: http://eepurl.com/hQpdqT

Instagram: https://www.instagram.com/sterlingmdphd

Twitter: https://twitter.com/sterlingmdphd

Facebook: https://www.facebook.com/sterlingmdphd

TikTok - https://www.tiktok.com/@sterlingmdphd

Subscribe to the Podcast:

Apple Podcasts: https://apple.co/3y438C9

Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c

Google Podcasts: https://bit.ly/3Olanei

References & Show Notes:

http://www.nicksterling.com/

Does muscle loss occur in people taking GLP-1 receptor agonists such as semaglutide (marketed as "Ozempic" and "Wegovy") or combined GLP-1/GIP agonists like tirzepatide (marketed as "Mounjaro")? In this episode, we discuss current evidence regarding these next-generation weight loss drugs and muscle wasting, as well as principles of preventing muscle loss in weight loss programs. #healthspan, #ozempic, #fitness, #muscle, #science Chapters: 00:00 - Intro 00:30 - Importance of Muscle in Weight Loss 01:19 - Muscle Loss During Weight Loss 02:03 - What Affects Muscle Mass During Weight Loss? 02:16 - Clinical Trials 04:59 - Preserving Muscle During Weight Loss 05:30 - Protein Intake 06:28 - Strength Training 06:59 - Monitoring Body Composition 07:26 - Summary Social & Website: Instagram - https://www.instagram.com/sterlingmdphd Twitter - https://twitter.com/sterlingmdphd Facebook - https://www.facebook.com/sterlingmdphd TikTok - https://www.tiktok.com/@sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Subscribe to the Podcast: Apple Podcasts: https://apple.co/3y438C9 Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c Google Podcasts: https://bit.ly/3Olanei References & Show Notes: http://www.nicksterling.com/ The content of this video is for general information purposes only and does not constitute the practice of medicine or any other healthcare professional services. The content of this video is not medical advice. No doctor-patient relationship is formed. The content of this video should not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.