A landmark study found that 85% of GLP-1 users stop within two years, with 47% not making it past 180 days. Reasons for discontinuation include limited access, side effects, and weight loss plateau. Lack of coaching and guidance is a major factor. GLP-1 medications have a wide range of health benefits, including cardiovascular disease, Alzheimer's, chronic kidney disease, addiction issues, joint dysfunction, autoimmune diseases, and GI issues. Lifestyle interventions, such as reducing processed food consumption and lowering carbohydrate intake, are crucial for long-term success. The dichotomy between Western medicine and holistic medicine is discussed, with the focus on addressing the root cause of health issues through lifestyle changes. In this conversation, Dr. J discusses the importance of nutrition, fasting, protein, and inflammation in achieving optimal health and weight loss. He emphasizes the benefits of sourdough bread over processed white bread and wheat, and recommends a diet rich in low glycemic fruits, vegetables, legumes, meats, and fish. Dr. J introduces the concept of aggressive, prolonged fasting and shares his structured approach called the Flow Protocol. He highlights the significance of muscle mass and its role in metabolic health and longevity. Lastly, he discusses the impact of inflammation on overall health and the potential benefits of low-dose naltrexone (LDN) in reducing inflammation