Known as tonics, cocaine wines were a hit when introduced in the late 1800s -- Angelo Mariani, a wealthy chemist from the island of Corsica, formulated his popular version, Vin Mariani -- in 1863. Cocaine wine is exactly what you think it is – a concoction of cocaine and wine -- and, it had an incredible fan base that included – spoiler alert – TWO popes.

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In the mid-1890s, Harry Kramer’s Sterling Remedy Co. introduced a product called, Cascarets Candy Cathartic. Cascarets were just laxatives, but the product blew away the competition. And a lot of that had to do with how it was marketed (a stroke of brilliance): Harry advertised the product as candy – and historians believe he may have been the first to have marketed medicine in that way. They were brown tablets – nothing special there – but they had a “pleasant taste -- almost as pleasant as chocolate.” In just a few years, by 1899, they’d become so popular that more than 5 million boxes were purchased annually. Harry, an entrepreneur who was adept at advertising – maybe that’s an understatement -- was only 38 years old at the time. So let’s meet this advertising sensation.

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Talking about the United Society of True Believers in Christ’s Second Appearing – a religious group commonly known as Shakers -- doesn't mean this is an episode about religion. They were disciplined and hard-working, and they were also innovative -- a good combination of characteristics that helped them finance their communal lives in a few successful ways. Their most successful business didn’t come from their famous furniture or inventions like the clothes pin, though. It was their knowledge of herbs and their practice of botanical medicine -- and what it was like for them to practice patent medicine in a time of snake oil sales.

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