Episodes

  • Fastenal: A Nuts & Bolts Success Story - [Business Breakdowns, EP.191]

    Fastenal: A Nuts & Bolts Success Story - [Business Breakdowns, EP.191]
    Nov 13 2024
    This is Zack Fuss. Today we're breaking down Fastenal. Starting as a small fastener retailer in Minnesota, the company has evolved into a mission-critical supply chain partner for its industrial customers. Today, the business sports a nearly $50 billion market cap and produces nearly $8 billion in sales. The impact of Fastenal's founder, Bob Kierlin, on Fastenal's commercial success can't be overstated. The industrial vending machine was his original idea, a vision he made a reality years later through its network of local branches, onsite locations, embedded with customers and innovative inventory management technologies. I'm joined by Delian Entchev, a portfolio manager at Aoris Investment Management. Today, we'll unpack the strategic choices, cultural DNA, and relentless customer focus that have fueled Fastenal's remarkable success. Please enjoy this Breakdown of Fastenal. Check out our new print publication Colossus Review. For the full show notes, transcript, and links to the best content to learn more, check out the episode page here. ----- This episode is brought to you by EightSleep, the temperature-controlled mattress cover that heats or cools your mattress to transform your sleep. The Pod 4 Ultra is the new gold standard in intelligent sleep systems. It can be added to your current mattress like a fitted sheet and is been clinically proven to give you up to an hour more quality of sleep every night. The cooling capability can cool your side of the bed to 20 degrees below room temperature, all managed by the pod's autopilot feature, which adjusts the temperature throughout the night. This holiday season, go to eightsleep.com/breakdowns and use code JOYS for up to $600 off the Pod 4 Ultra when bundled. — This episode is brought to you by Ridgeline. Ridgeline has built a complete, real-time, modern operating system for investment managers. It handles trading, portfolio management, compliance, customer reporting, and much more through an all-in-one real-time cloud platform. I think this platform will become the standard for investment managers, and if you run an investing firm, I highly recommend you find time to speak with them. Head to ridgelineapps.com to learn more about the platform. ----- Business Breakdowns is a property of Colossus, LLC. For more episodes of Business Breakdowns, visit joincolossus.com/episodes. Editing and post-production work for this episode was provided by The Podcast Consultant (https://thepodcastconsultant.com). Show Notes (00:00:00) Welcome to Business Breakdowns (00:07:44) Understanding Fastenal's Business Model (00:08:24) The Amazon Connection (00:10:09) Fastenal's Founding Story (00:12:06) Pivot to Business Customers (00:13:18) Empowering Employees for Growth (00:14:44) Frugality and Culture at Fastenal (00:17:33) Expansion and Evolution (00:19:07) Onsite Services and Technological Innovations (00:22:17) International Growth and Future Opportunities (00:23:16) Financial Profile and Customer Relationships (00:28:36) Customer Integration: Fastenal's On-Site Business Model (00:29:21) Three Pillars of Fastenal's Service: Experts, Inventory, and Technology (00:30:39) Customization and Proximity: Tailoring On-Site Solutions (00:31:56) Economic Relationships and Customer Spend (00:33:56) Fastenal's Competitive Edge: Value Proposition and Culture (00:37:54) Growth and Market Share: Fastenal's Expansion Strategies (00:44:52) Financial Discipline and Capital Allocation (00:50:14) Lessons from Fastenal: Transparency and In-Person Visits
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    51 mins
  • Demographics Driving Real Estate - [Business Breakdowns, EP.190]

    Demographics Driving Real Estate - [Business Breakdowns, EP.190]
    Nov 6 2024
    Today, my guest is Fernando De Leon, founder of Leon Capital Group. Fernando operates 14 different businesses under the Leon Capital umbrella, which vary across real estate, healthcare, and financial services. But as you will hear in our conversation, the businesses are connected and instruct one another. The connective tissue throughout this conversation is how demographic insight sits underneath everything and is the foundation of what makes this business possible. As you will hear, there's no better person to talk about demographic dynamics than Fernando. Please enjoy this Breakdown on the demographics driving real estate. For the full show notes, transcript, and links to the best content to learn more, check out the episode page here. ----- This episode is brought to you by Alphasense. AlphaSense has completely transformed the research process with cutting-edge AI technology and a vast collection of top-tier, reliable business content. Imagine completing your research five to ten times faster with search that delivers the most relevant results, helping you make high-conviction decisions with confidence. AlphaSense provides access to over 300 million premium documents, including company filings, earnings reports, press releases, and more from public and private companies. Invest Like the Best listeners can get a free trial now at Alpha-Sense.com/Invest and experience firsthand how AlphaSense and Tegas help you make smarter decisions faster. — This episode is brought to you by EightSleep, the temperature-controlled mattress cover that heats or cools your mattress to transform your sleep. The Pod 4 Ultra is the new gold standard in intelligent sleep systems. It can be added to your current mattress like a fitted sheet and is been clinically proven to give you up to an hour more quality of sleep every night. The cooling capability can cool your side of the bed to 20 degrees below room temperature, all managed by the pod's autopilot feature, which adjusts the temperature throughout the night. Go to eightsleep.com/breakdowns and use the code glueguys for $350 off. ----- Business Breakdowns is a property of Colossus, LLC. For more episodes of Business Breakdowns, visit joincolossus.com/episodes. Editing and post-production work for this episode was provided by The Podcast Consultant (https://thepodcastconsultant.com). Show Notes (00:00:00) Introduction and Background (00:05:55) Early Life and Education (00:08:03) Real Estate and Demographics (00:11:02) Business Ventures and Strategies (00:13:17) Challenges and Opportunities in Real Estate (00:17:13) Efficient Resource Management (00:18:12) Downside Protection Strategies (00:19:59) Insurance and System Optimization (00:21:43) Real Estate Cyclicality and Capital Support (00:24:28) Challenges in Housing Development (00:25:58) Target Markets and Demographic Trends (00:29:39) Opportunities in Secondary Markets (00:31:49) Nearshoring and Global Trade (00:43:13) Future Outlook and Technological Impact (00:55:02) Lessons From Breaking Down The Industry
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    53 mins
  • Merck & Co: Blockbuster Drugs - [Business Breakdowns, EP.189]

    Merck & Co: Blockbuster Drugs - [Business Breakdowns, EP.189]
    Oct 30 2024
    This is Zack Fuss. Today we are breaking down Merck, one of the world's largest and oldest pharmaceutical companies. The company has been shaping medicine and fostering innovation for over 130 years. From its humble beginnings as a small family pharmacy in Germany, today's iteration of Merck has transformed into a nearly $300 billion market cap business with particular strength in oncology. At the heart of Merck's recent success is Keytruda, arguably the world's most important cancer drug. This single medication now generates over $25 billion in annual revenue. But, Merck's story is not only about Keytruda, it's about a company that's consistently pursued innovative science, combined with a handful of bold decisions, which resulted in the development of some of the world's first vaccines and breakthroughs in diabetes treatment. To break down Merck, I am joined by Ashwin Varma, who is currently a medical student at UT Health San Antonio. We unpack Merck's business model, explore its industry-leading oncology franchise, and examine its pipeline of future drugs, and understand how they have navigated the complex world of pharmaceutical patents and regulation. Please enjoy this Breakdown on Merck. For the full show notes, transcript, and links to the best content to learn more, check out the episode page here. ----- This episode is brought to you by Alphasense. AlphaSense has completely transformed the research process with cutting-edge AI technology and a vast collection of top-tier, reliable business content. Imagine completing your research five to ten times faster with search that delivers the most relevant results, helping you make high-conviction decisions with confidence. AlphaSense provides access to over 300 million premium documents, including company filings, earnings reports, press releases, and more from public and private companies. Invest Like the Best listeners can get a free trial now at Alpha-Sense.com/Invest and experience firsthand how AlphaSense and Tegas help you make smarter decisions faster. — This episode is brought to you by EightSleep, the temperature-controlled mattress cover that heats or cools your mattress to transform your sleep. The Pod 4 Ultra is the new gold standard in intelligent sleep systems. It can be added to your current mattress like a fitted sheet and is been clinically proven to give you up to an hour more quality of sleep every night. The cooling capability can cool your side of the bed to 20 degrees below room temperature, all managed by the pod's autopilot feature, which adjusts the temperature throughout the night. Go to eightsleep.com/breakdowns and use the code glueguys for $350 off. ----- Business Breakdowns is a property of Colossus, LLC. For more episodes of Business Breakdowns, visit joincolossus.com/episodes. Editing and post-production work for this episode was provided by The Podcast Consultant (https://thepodcastconsultant.com). Show Notes (00:00:00) Welcome to Business Breakdowns (00:05:50) History and Evolution of Merck (00:08:32) Merck's Blockbuster Era and Challenges (00:10:51) Understanding the Pharma Industry (00:15:32) Merck's Current Business and Financials (00:20:48) Patent Protection and R&D Strategies (00:35:00) Checkpoint Inhibitors: A Breakthrough in Cancer Treatment (00:35:54) The Rise of Keytruda: From Trials to Triumph (00:37:56) Keytruda's Expanding Indications and Market Impact (00:39:56) Understanding Cancer Therapy Lines (00:42:09) Keytruda's Competitive Landscape and Future Challenges (00:46:33) Merck's Strategy for Post-Patent Success (00:57:41) Leadership and Organizational Structure at Merck (01:04:01) Lessons from breaking down Merck
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    1 hr and 6 mins
  • American Tower: Signals and Stability - [Business Breakdowns, EP.188]

    American Tower: Signals and Stability - [Business Breakdowns, EP.188]
    Oct 25 2024
    Today we are breaking down American Tower: the REIT, the communications giant, and the infrastructure asset. To break down American Tower I'm joined by William Heard, founder and CIO of Heard Capital Management. William founded Heard Capital in 2011. Today, the firm manages $2 billion in assets, holds about 15 to 20 names, and has very specific criteria for investing in companies. We cover AMT from all angles—the long life, physical assets that underpin the business, the contracted and highly visible revenue stream, the secular growth story, and some of the micro dynamics. American Tower represents so many things in the economy, so it made for a very interesting and wide-ranging conversation. Please enjoy this Breakdown of American Tower. For the full show notes, transcript, and links to the best content to learn more, check out the episode page here. ----- This episode is brought to you by Alphasense. AlphaSense has completely transformed the research process with cutting-edge AI technology and a vast collection of top-tier, reliable business content. Imagine completing your research five to ten times faster with search that delivers the most relevant results, helping you make high-conviction decisions with confidence. AlphaSense provides access to over 300 million premium documents, including company filings, earnings reports, press releases, and more from public and private companies. Invest Like the Best listeners can get a free trial now at Alpha-Sense.com/Invest and experience firsthand how AlphaSense and Tegas help you make smarter decisions faster. — This episode is brought to you by Public: Invest in stocks, bonds, options, crypto, and more in one place. A Bond Account is a self-directed brokerage account with Public Investing, member FINRA/SIPC. Deposits into this account are used to purchase 10 investment-grade and high-yield bonds. The [6.7%] yield is the average annualized yield to maturity (YTM) across all ten bonds in the Bond Account, before fees, as of [9/05/2024]. A bond’s yield is a function of its market price, which can fluctuate; therefore a bond’s YTM is “locked in” when the bond is purchased. Your yield at time of purchase may be different from the yield shown here. The “locked in” YTM is not guaranteed; you may receive less than the YTM of the bonds in the Bond Account if you sell any of the bonds before maturity, or if the issuer calls or defaults on the bond. Public Investing charges a markup on each bond trade. See our Fee Schedule. Bond Accounts are not recommendations of individual bonds or default allocations. The bonds in the Bond Account have not been selected based on your needs or risk profile. You should evaluate each bond before investing in a Bond Account. The bonds in your Bond Account will not be rebalanced and allocations will not be updated, except for Corporate Actions. ----- Business Breakdowns is a property of Colossus, LLC. For more episodes of Business Breakdowns, visit joincolossus.com/episodes. Editing and post-production work for this episode was provided by The Podcast Consultant (https://thepodcastconsultant.com). Show Notes (00:00:00) Welcome to Business Breakdowns (00:03:42) Understanding American Tower's Infrastructure (00:04:41) Market Size and Share (00:05:44) Ownership and Construction of Towers (00:06:51) Investment and Growth in Tower Infrastructure (00:11:32) Data Centers and Their Importance (00:14:34) Leasing Model and Revenue Structure (00:17:02) Management and Financial Strategy (00:18:42) Acquisitions and Growth Strategy (00:21:39) Management Teams and Strategic Priorities (00:22:35) Capital Allocation and Dividend Strategy (00:24:09) REITs and Market Dynamics (00:26:49) International Operations and Challenges (00:29:19) Carrier Spending and Revenue Streams (00:37:57) Risks and Competitive Landscape (00:38:58) Lessons from Breaking Down American Tower
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    41 mins
  • AIG: Rise, Fall, and Rebirth - [Business Breakdowns, EP.187]

    AIG: Rise, Fall, and Rebirth - [Business Breakdowns, EP.187]
    Oct 16 2024
    Today, we are breaking down the insurance giant AIG. AIG's story is one of a remarkable turnaround, a tale of a global insurance giant emerging from near collapse during the great financial crisis. Over nearly two decades, AIG has transformed itself into a more focused and efficient property and casualty insurer. To grasp the magnitude of AIG's journey, consider this: During the financial crisis, the company required a $180 billion bailout from the U. S. government, a sum it fully repaid with interest. To help tell the story of AIG's transformation and its current position, I'm joined by Austin Hawley, Portfolio Manager at Diamond Hill. Today, under Peter Zaffino's leadership, AIG has refocused its underwriting efforts, returning to profitability while divesting noncore businesses, including the demerger of its life insurance arm, Corebridge. The AIG of today stands as a near pure play specialty insurer with a focus on achieving top-quartile industry returns. Please enjoy this breakdown of AIG For the full show notes, transcript, and links to the best content to learn more, check out the episode page here. ----- This episode is brought to you by Tegus, where we're changing the game in investment research. Step away from outdated, inefficient methods and into the future with our platform, proudly hosting over 100,000 transcripts – with over 25,000 transcripts added just this year alone. Our platform grows eight times faster and adds twice as much monthly content as our competitors, putting us at the forefront of the industry. Plus, with 75% of private market transcripts available exclusively on Tegus, we offer insights you simply can't find elsewhere. See the difference a vast, quality-driven transcript library makes. Unlock your free trial at tegus.com/patrick. — This episode is brought to you by EightSleep, the temperature-controlled mattress cover that heats or cools your mattress to transform your sleep. The Pod 4 Ultra is the new gold standard in intelligent sleep systems. It can be added to your current mattress like a fitted sheet and is been clinically proven to give you up to an hour more quality of sleep every night. The cooling capability can cool your side of the bed to 20 degrees below room temperature, all managed by the pod's autopilot feature, which adjusts the temperature throughout the night. Go to eightsleep.com/breakdowns and use the code glueguys for $350 off. ----- Business Breakdowns is a property of Colossus, LLC. For more episodes of Business Breakdowns, visit joincolossus.com/episodes. Editing and post-production work for this episode was provided by The Podcast Consultant (https://thepodcastconsultant.com). Show Notes (00:00:00) Introduction to Business Breakdowns (00:04:57) AIG: A Tale of Turnaround (00:05:31) Understanding PNC Insurance (00:06:56) AIG's Historical Context (00:09:58) AIG's Post-Crisis Struggles (00:15:17) The 2017 Management Overhaul (00:21:42) Berkshire Hathaway's Role (00:24:26) Strategic Moves and Divestitures (00:28:32) AIG's Strategic Transformation (00:30:40) Understanding AIG's Business Metrics (00:32:10) Specialty Lines and Global Footprint (00:33:31) AIG's Niche Businesses (00:34:47) Evaluating Insurance Companies (00:38:04) Competitive Advantages in Insurance (00:42:04) Pricing Environment and Market Dynamics (00:45:35) AIG's Investment Strategy (00:48:25) Competitors and Comparisons (00:50:03) Lessons from Breaking Down AIG's Turnaround
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    50 mins
  • Gregorys Coffee: From Bean to Dream - [Business Breakdowns, EP.186]

    Gregorys Coffee: From Bean to Dream - [Business Breakdowns, EP.186]
    Oct 9 2024
    Today we are getting into the world of coffee with Gregory Zamfotis, the founder of Gregorys Coffee. We breakdown the New York City born coffee chain that now spans across twelve US states. This is a true look into what it takes to open up a coffee shop and the economics behind it. We get into what it's like to innovate in an industry where innovation can last a week before a competitor releases the same thing on their menu. And Greg also shares all of the challenges around going from one store to a second store to scaling into what Gregorys is today. Please enjoy this Breakdown of Gregorys coffee. For the full show notes, transcript, and links to the best content to learn more, check out the episode page here. ----- This episode is brought to you by EightSleep, the temperature-controlled mattress cover that heats or cools your mattress to transform your sleep. The Pod 4 Ultra is the new gold standard in intelligent sleep systems. It can be added to your current mattress like a fitted sheet and is been clinically proven to give you up to an hour more quality of sleep every night. The cooling capability can cool your side of the bed to 20 degrees below room temperature, all managed by the pod's autopilot feature, which adjusts the temperature throughout the night. Go to eightsleep.com/breakdowns and use the code glueguys for $350 off. --- This episode is brought to you by Public: Invest in stocks, bonds, options, crypto, and more in one place. A Bond Account is a self-directed brokerage account with Public Investing, member FINRA/SIPC. Deposits into this account are used to purchase 10 investment-grade and high-yield bonds. As of 9/26/24, the average, annualized yield to worst (YTW) across the Bond Account is greater than 6%. A bond’s yield is a function of its market price, which can fluctuate; therefore, a bond’s YTW is not “locked in” until the bond is purchased, and your yield at time of purchase may be different from the yield shown here. The “locked in” YTW is not guaranteed; you may receive less than the YTW of the bonds in the Bond Account if you sell any of the bonds before maturity or if the issuer defaults on the bond. Public Investing charges a markup on each bond trade. See our Fee Schedule. Bond Accounts are not recommendations of individual bonds or default allocations. The bonds in the Bond Account have not been selected based on your needs or risk profile. See https://public.com/disclosures/bond-account to learn more. ----- Business Breakdowns is a property of Colossus, LLC. For more episodes of Business Breakdowns, visit joincolossus.com/episodes. Editing and post-production work for this episode was provided by The Podcast Consultant (https://thepodcastconsultant.com). Show Notes (00:00:00) Welcome to Business Breakdowns (00:04:33) Growing Up in the Food and Beverage Industry (00:06:57) Deciding to Pursue Gregorys Coffee (00:10:04) Opening the First Gregorys Coffee Location (00:16:42) Innovating and Expanding the Business (00:28:57) Challenges and Lessons in Scaling Up (00:50:52) Comparing Quality: Mass Chains vs. Our Espresso (00:53:27) Our Mission and Core Values (00:58:10) Consistency Across Locations (01:00:46) Partnership with Simon Property Group (01:07:36) The Role of Technology and Loyalty Programs (01:12:16) Balancing Order Ahead and In-Store Experience (01:15:47) The Cost and Challenges of Opening a Coffee Shop (01:22:13) Handling Competition and Maintaining Quality (01:24:29) The Coffee Community and Industry Trends (01:27:16) Vision for Future Expansion (01:29:12) Building a Strong Team and Infrastructure (01:34:04) Lessons Learned and Entrepreneurial Advice
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    1 hr and 39 mins
  • Going Activist in Japan - [Business Breakdowns, EP.185]

    Going Activist in Japan - [Business Breakdowns, EP.185]
    Oct 2 2024
    Today, we are covering what might be the most interesting investment strategy I've come across in a long time: activism in Japan. In this episode, I talk with Masumi Nishida, Partner and Managing Director for Dalton's Tokyo research office. As part of this intro, I brought on the catalyst for this episode, Nick Bartolo, founder and Managing Partner of Essential Partners. The conversation delves into the opportunities for activism in the Japanese market, highlighting the historically low valuations of Japanese equities and the cultural dynamics contributing to this scenario. We discuss corporate governance reforms and the Tokyo Stock Exchange's role in improving market efficiency and shareholder value. And, Masumi highlights several case studies that illustrate successful activist strategies, including promoting management buyouts and enhancing capital allocation. Please enjoy this unique Breakdown on Japan activism. For the full show notes, transcript, and links to the best content to learn more, check out the episode page here. ----- This episode is brought to you by Tegus, where we're changing the game in investment research. Step away from outdated, inefficient methods and into the future with our platform, proudly hosting over 100,000 transcripts – with over 25,000 transcripts added just this year alone. Our platform grows eight times faster and adds twice as much monthly content as our competitors, putting us at the forefront of the industry. Plus, with 75% of private market transcripts available exclusively on Tegus, we offer insights you simply can't find elsewhere. See the difference a vast, quality-driven transcript library makes. Unlock your free trial at tegus.com/patrick. --- This episode is brought to you by Public: Invest in stocks, bonds, options, crypto, and more in one place. A Bond Account is a self-directed brokerage account with Public Investing, member FINRA/SIPC. Deposits into this account are used to purchase 10 investment-grade and high-yield bonds. The [6.7%] yield is the average annualized yield to maturity (YTM) across all ten bonds in the Bond Account, before fees, as of [9/05/2024]. A bond’s yield is a function of its market price, which can fluctuate; therefore a bond’s YTM is “locked in” when the bond is purchased. Your yield at time of purchase may be different from the yield shown here. The “locked in” YTM is not guaranteed; you may receive less than the YTM of the bonds in the Bond Account if you sell any of the bonds before maturity, or if the issuer calls or defaults on the bond. Public Investing charges a markup on each bond trade. See our Fee Schedule. Bond Accounts are not recommendations of individual bonds or default allocations. The bonds in the Bond Account have not been selected based on your needs or risk profile. You should evaluate each bond before investing in a Bond Account. The bonds in your Bond Account will not be rebalanced and allocations will not be updated, except for Corporate Actions. ----- Editing and post-production work for this episode was provided by The Podcast Consultant (https://thepodcastconsultant.com). Show Notes (00:00:00) Welcome to Business Breakdowns (00:00:40) Understanding Japan's Market Valuation (00:02:08) Cultural Dynamics and Cash Reserves (00:03:47) Financial Literacy and Balance Sheet Optimization (00:08:27) Corporate Governance and TSE Reform (00:13:12) Challenges of Cross Shareholdings (00:18:24) Opportunities in Small to Mid Cap Companies (00:21:31) Activism Strategies and Proposals (00:26:51) Bellpost's Strategic Moves and Initial Proposals (00:27:24) Challenges with Shareholder Support in Japan (00:29:11) Management Buyouts and Capital Allocation (00:30:33) Case Study: Ihara Science's Path to Privatization (00:31:43) Financing Dynamics in Japanese MBOs (00:34:48) Case Study: Mitsuboshi Belting's Shareholder Proposals (00:40:35) Case Study: Ihara Science's MBO Success (00:45:55) Current Market Dynamics and Future Outlook
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    1 hr
  • RTW: Investing across Healthcare - [Business Breakdowns, EP.184]

    RTW: Investing across Healthcare - [Business Breakdowns, EP.184]
    Sep 27 2024
    Today we are breaking down healthcare, one of the most impactful sectors in the world, yet one of the most unique for investors. My guests are Rod Wong, founder and CIO of RTW Investments, and Stephanie Sirota, chief business officer of RTW Investments. RTW was founded in 2009 and operates a sector-specific strategy in healthcare. We discuss the evolution of their model, which feels particularly important given how much it aligns with the healthcare investment process. We cover the various phases of drug investments, the unique dynamics of founders and team building, and we get into some of the more philosophical discussions around regulation in the industry. Please enjoy this breakdown on healthcare. Editor-in-Chief application here. For the full show notes, transcript, and links to the best content to learn more, check out the episode page here. ----- This episode is brought to you by Ridgeline. Ridgeline has built a complete, real-time, modern operating system for investment managers. It handles trading, portfolio management, compliance, customer reporting, and much more through an all-in-one real-time cloud platform. I think this platform will become the standard for investment managers, and if you run an investing firm, I highly recommend you find time to speak with them. Head to ridgelineapps.com to learn more about the platform. --- This episode is brought to you by Public: Invest in stocks, bonds, options, crypto, and more in one place. A Bond Account is a self-directed brokerage account with Public Investing, member FINRA/SIPC. Deposits into this account are used to purchase 10 investment-grade and high-yield bonds. The [6.7%] yield is the average annualized yield to maturity (YTM) across all ten bonds in the Bond Account, before fees, as of [9/05/2024]. A bond’s yield is a function of its market price, which can fluctuate; therefore a bond’s YTM is “locked in” when the bond is purchased. Your yield at time of purchase may be different from the yield shown here. The “locked in” YTM is not guaranteed; you may receive less than the YTM of the bonds in the Bond Account if you sell any of the bonds before maturity, or if the issuer calls or defaults on the bond. Public Investing charges a markup on each bond trade. See our Fee Schedule. Bond Accounts are not recommendations of individual bonds or default allocations. The bonds in the Bond Account have not been selected based on your needs or risk profile. You should evaluate each bond before investing in a Bond Account. The bonds in your Bond Account will not be rebalanced and allocations will not be updated, except for Corporate Actions. ----- Business Breakdowns is a property of Colossus, LLC. For more episodes of Business Breakdowns, visit joincolossus.com/episodes. Editing and post-production work for this episode was provided by The Podcast Consultant (https://thepodcastconsultant.com). Show Notes (00:00:00) Welcome to Business Breakdowns (00:07:50) Phases of Healthcare Product Lifecycle (00:09:03) Challenges and Opportunities in Biotech (00:14:01) Investment Strategies in Healthcare (00:16:47) The Evolution of RTW and Team Structure (00:20:11) Public and Private Market Dynamics (00:26:24) Gene Therapy: A Case Study (00:33:08) Future of Healthcare Innovation (00:46:11) Global Biotech Landscape: US Dominance and International Opportunities (00:48:29) Big Pharma Winners and Losers: A Decade in Review (00:51:11) Impact of the Inflation Reduction Act (IRA) on Drug Development (00:54:55) Regulatory Changes and Their Impact on Innovation (01:10:08) M&A in Biotech: A Critical Component for Success (01:15:57) GLP-1 Drugs: Market Impact and Future Prospects (01:20:38) Current Biotech Market: Opportunities and Future Outlook
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    1 hr and 7 mins