Madness and Memory
The Discovery of Prions - A New Biological Principle of Disease
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Madness and Memory
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Narrated by:
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Joe Barrett
About this listen
In 1997, Stanley B. Prusiner received a Nobel Prize, the world's most prestigious award for achievement in physiology or medicine. That he was the sole recipient of the award for the year was entirely appropriate. His struggle to identify the agent responsible for ravaging the brains of animals suffering from scrapie and mad cow disease, and of humans with Creutzfeldt-Jakob disease, had been waged largely alone and, in some cases, in the face of strenuous disagreement.
In this book, Prusiner tells the remarkable story of his discovery of prions - infectious proteins that replicate and cause disease but surprisingly contain no genetic material - and reveals how superb and meticulous science is actually practiced with talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases. Prusiner's hypothesis, once considered heresy, now stands as accepted science and the basis for developing diagnoses and eventual cures. He closes with a meditation on the legacy of his discovery: What will it take to cure Alzheimer's, Parkinson's, Lou Gehrig's, and other devastating diseases of the brain?
Download the accompanying reference guide.©2014 Stanley B. Prusiner, MD (P)2015 Audible, Inc.Listeners also enjoyed...
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Overall4.5 out of 5 stars 52
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Performance4.5 out of 5 stars 42
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Story4.5 out of 5 stars 42
Most of the 25,000 genes we possess are the same for all of us. Compatibility genes are those that vary most from person to person and give each of us a unique molecular signature. These genes determine both the extent to which we are susceptible to a vast range of illnesses and the different ways each of us fights disease.
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5 out of 5 stars
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If interested in medicine, got to read
- By Howard Sterling on 06-29-16
By: Daniel M. Davis
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The Gene
- An Intimate History
- By: Siddhartha Mukherjee
- Narrated by: Dennis Boutsikaris
- Length: 19 hrs and 22 mins
- Unabridged
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Overall4.5 out of 5 stars 5,893
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Performance4.5 out of 5 stars 5,171
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Story4.5 out of 5 stars 5,124
The extraordinary Siddhartha Mukherjee has written a biography of the gene as deft, brilliant, and illuminating as his extraordinarily successful biography of cancer. Weaving science, social history, and personal narrative to tell us the story of one of the most important conceptual breakthroughs of modern times, Mukherjee animates the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.
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5 out of 5 stars
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It's a Wonderful Book
- By JKC on 06-02-16
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A Crack in Creation
- Gene Editing and the Unthinkable Power to Control Evolution
- By: Jennifer A. Doudna, Samuel H. Sternberg
- Narrated by: Erin Bennett
- Length: 9 hrs and 22 mins
- Unabridged
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Overall4.5 out of 5 stars 1,360
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Performance4.5 out of 5 stars 1,162
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Story4.5 out of 5 stars 1,161
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.
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5 out of 5 stars
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In to the abyss we ascend, a scary future
- By Philomath on 06-17-17
By: Jennifer A. Doudna, and others
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101 Theory Drive
- A Neuroscientist's Quest for Memory
- By: Terry McDermott
- Narrated by: Stephen Hoye
- Length: 8 hrs and 55 mins
- Unabridged
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Overall4 out of 5 stars 167
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Performance4 out of 5 stars 63
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Story4 out of 5 stars 65
It's not fiction: Gary Lynch is the real thing, the epitome of the rebel scientist - malnourished, contentious, inspiring, explosive, remarkably ambitious, consistently brilliant. He is one of the foremost figures of contemporary neuroscience, and his decades-long quest to understand the inner workings of the brain's memory machine has begun to pay off.
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5 out of 5 stars
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Pretty Dang Funny
- By Will on 05-14-10
By: Terry McDermott
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Headstrong
- 52 Women Who Changed Science-and the World
- By: Rachel Swaby
- Narrated by: Lauren Fortgang
- Length: 7 hrs and 1 min
- Unabridged
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Overall4 out of 5 stars 64
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Performance4 out of 5 stars 54
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Story4.5 out of 5 stars 54
In 2013, the New York Times published an obituary for Yvonne Brill. It began: “She made a mean beef stroganoff, followed her husband from job to job, and took eight years off from work to raise three children.” It wasn’t until the second paragraph that readers discovered why the Times had devoted several hundred words to her life: Brill was a brilliant rocket scientist who invented a propulsion system to keep communications satellites in orbit, and had recently been awarded the National Medal of Technology and Innovation.
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4 out of 5 stars
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Role models for young women
- By mtsuda90 on 06-25-16
By: Rachel Swaby
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Rigor Mortis
- How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions
- By: Richard Harris
- Narrated by: Joe Delafield
- Length: 5 hrs and 56 mins
- Unabridged
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Overall4.5 out of 5 stars 117
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Performance4.5 out of 5 stars 100
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Story4.5 out of 5 stars 99
American taxpayers spend $30 billion annually funding biomedical research, but over half of these studies can't be replicated due to poor experimental design, improper methods, and sloppy statistics. Bad science doesn't just hold back medical progress, it can sign the equivalent of a death sentence for terminal patients. In Rigor Mortis, Richard Harris explores these urgent issues with vivid anecdotes, personal stories, and interviews with the top biomedical researchers. We need to fix our dysfunctional biomedical system - before it's too late.
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5 out of 5 stars
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Eye opening introduction to biomedical R&D
- By Amazon Customer on 09-18-18
By: Richard Harris
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The Family That Couldn't Sleep
- A Medical Mystery
- By: D.T. Max
- Narrated by: Grover Gardner
- Length: 8 hrs and 45 mins
- Unabridged
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Overall4 out of 5 stars 488
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Performance4.5 out of 5 stars 270
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Story4.5 out of 5 stars 273
For 200 years, a noble Venetian family has suffered from an inherited disease that strikes their members in middle age, stealing their sleep, eating holes in their brains, and ending their lives in a matter of months. In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. What these strange conditions share is their cause: prions.
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5 out of 5 stars
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A great scientific mystery
- By David on 11-04-06
By: D.T. Max
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Editing Humanity
- The CRISPR Revolution and the New Era of Genome Editing
- By: Kevin Davies
- Narrated by: Kevin Davies
- Length: 16 hrs and 17 mins
- Unabridged
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Overall4.5 out of 5 stars 76
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Performance4.5 out of 5 stars 65
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Story4.5 out of 5 stars 65
Engrossing and captivating, Editing Humanity takes listeners inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to edit the DNA of any organism down to the individual building blocks of the genetic code. Davies introduces listeners to arguably the most profound scientific breakthrough of our time. He tracks the scientists on the front lines of its research to the patients whose powerful stories bring the narrative movingly to human scale.
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4 out of 5 stars
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Excellent content, solid execution
- By Samuel Finlayson on 01-25-21
By: Kevin Davies
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The Cancer Chronicles
- Unlocking Medicine's Deepest Mystery
- By: George Johnson
- Narrated by: Arthur Morey
- Length: 8 hrs and 19 mins
- Unabridged
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Overall4.5 out of 5 stars 62
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Performance4.5 out of 5 stars 53
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Story4.5 out of 5 stars 53
When the woman he loved was diagnosed with a metastatic cancer, science writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is a revolution under way - an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease.
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5 out of 5 stars
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A quick read - hard to put down
- By Digital Dilema on 09-06-13
By: George Johnson
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At the Edge of Uncertainty
- 11 Discoveries Taking Science by Surprise
- By: Michael Brooks
- Narrated by: Sean Runnette
- Length: 9 hrs and 12 mins
- Unabridged
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Overall4 out of 5 stars 1,201
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Performance4.5 out of 5 stars 1,085
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Story4.5 out of 5 stars 1,084
The atom, the big bang, DNA, natural selection - all are ideas that have revolutionized science; and all were dismissed out of hand when they first appeared. The surprises haven't stopped in recent years, and in At the Edge of Uncertainty, best-selling author Michael Brooks investigates the new wave of radical insights that are shaping the future of scientific discovery.
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1 out of 5 stars
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All smoke, no fire
- By Kenton on 07-25-15
By: Michael Brooks
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The Emperor of All Maladies
- A Biography of Cancer
- By: Siddhartha Mukherjee
- Narrated by: Fred Sanders
- Length: 22 hrs and 18 mins
- Unabridged
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Overall5 out of 5 stars 4,689
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Performance5 out of 5 stars 4,110
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Story5 out of 5 stars 4,088
The Emperor of All Maladies reveals the many faces of an iconic, shape-shifting disease that is the defining plague of our generation. The story of cancer is a story of human ingenuity, resilience, and perseverance but also of hubris, arrogance, paternalism, and misperception, all leveraged against a disease that, just three decades ago, was thought to be easily vanquished in an all-out "war against cancer".
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5 out of 5 stars
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Incredible
- By S.R.E. on 03-02-16
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Hood
- Trailblazer of the Genomics Age
- By: Luke Timmerman, David Baltimore
- Narrated by: Xe Sands
- Length: 10 hrs and 53 mins
- Unabridged
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Overall4.5 out of 5 stars 34
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Performance4.5 out of 5 stars 30
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Story4.5 out of 5 stars 30
Lee Hood did that rarest of things. He enabled scientists to see things they couldn't see before and do things they hadn't dreamed of doing. Scientists can now sequence complete human genomes in a day, setting in motion a revolution that is personalizing medicine. Hood, a son of the American West, was an unlikely candidate to transform biology. But with ferocious drive, he led a team at Caltech that developed the automated DNA sequencer, the tool that paved the way for the Human Genome Project.
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4 out of 5 stars
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A Revealing Biography
- By Jean on 07-27-17
By: Luke Timmerman, and others
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The Remedy
- Robert Koch, Arthur Conan Doyle, and the Quest to Cure Tuberculosis
- By: Thomas Goetz
- Narrated by: Donald Corren
- Length: 9 hrs and 55 mins
- Unabridged
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Overall4.5 out of 5 stars 584
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Performance4.5 out of 5 stars 512
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Story4.5 out of 5 stars 509
In 1875, tuberculosis was the deadliest disease in the world, accountable for a third of all deaths. A diagnosis of TB - often called consumption - was a death sentence. Then, in a triumph of medical science, a German doctor named Robert Koch deployed an unprecedented scientific rigor to discover the bacteria that caused TB. Koch soon embarked on a remedy - a remedy that would be his undoing. When Koch announced his cure for consumption, Arthur Conan Doyle, then a small-town doctor in England and sometime writer, went to Berlin to cover the event.
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4 out of 5 stars
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thought-provoking
- By Jean on 07-06-14
By: Thomas Goetz
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Polio
- An American Story
- By: David M. Oshinsky
- Narrated by: Jonathan Hogan
- Length: 14 hrs and 37 mins
- Unabridged
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Overall4.5 out of 5 stars 594
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Performance4.5 out of 5 stars 424
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Story4.5 out of 5 stars 423
This comprehensive and gripping narrative, which received the 2006 Pulitzer Prize for history, covers all the challenges, characters, and controversies in America's relentless struggle against polio. Funded by philanthropy and grassroots contributions, Salk's killed-virus vaccine (1954) and Sabin's live-virus vaccine (1961) began to eradicate this dreaded disease.
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5 out of 5 stars
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Wonderful
- By Patricia B Tripoli on 07-22-08
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Happy Accidents
- Serendipity in Major Medical Breakthroughs in the Twentieth Century
- By: Morton A. Meyers
- Narrated by: Richard Waterhouse
- Length: 12 hrs and 37 mins
- Unabridged
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Overall4.5 out of 5 stars 50
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Performance4 out of 5 stars 45
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Story4.5 out of 5 stars 44
Happy Accidents is a fascinating, entertaining, and highly accessible look at the surprising role serendipity has played in some of the most important medical discoveries in the 20th century. What do penicillin, chemotherapy drugs, X-rays, Valium, the Pap smear, and Viagra have in common? They were each discovered accidentally, stumbled upon in the search for something else. In discussing medical breakthroughs, Dr. Morton Meyers makes a cogent, highly engaging argument for a more creative, rather than purely linear, approach to science. And it may just save our lives!
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1 out of 5 stars
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Don't waste your money!
- By Amazon Customer on 03-20-16
By: Morton A. Meyers
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Plague of Corruption
- Restoring Faith in the Promise of Science
- By: Dr. Judy Mikovits, Kent Heckenlively, Robert F. Kennedy Jr.
- Narrated by: Mariel Hemingway
- Length: 10 hrs and 10 mins
- Unabridged
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Overall5 out of 5 stars 808
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Performance4.5 out of 5 stars 721
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Story5 out of 5 stars 719
Dr. Judy Mikovits is a modern-day Rosalind Franklin, a brilliant researcher shaking up the old boys' club of science with her groundbreaking discoveries. And like many women who have trespassed into the world of men, she uncovered decades-old secrets that many would prefer to stay buried.
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5 out of 5 stars
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If only most of the public knew these facts
- By David Getoff, CCN on 06-18-20
By: Dr. Judy Mikovits, and others
What listeners say about Madness and Memory
Average customer ratingsReviews - Please select the tabs below to change the source of reviews.
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Overall5 out of 5 stars
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Performance5 out of 5 stars
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Story5 out of 5 stars
- Sara Bolin
- 06-08-22
Spectacular
Wow. I have had an interest in prion diseases for years, and this book was absolutely superb. The writing painted an amazing picture of his process in answering the question: What is the infectious agent responsible for CJD, Kuru, and other spongiform encephalopathies? The relentless search for empirical data outlined in this book was captivating. I will absolutely listen again and also find a hard copy. I hope to add to the knowledge of prior diseases and help discover ways to mitigate the devastating effects caused by these insidious little denatured proteins in the future.
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Overall5 out of 5 stars
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Performance5 out of 5 stars
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Story5 out of 5 stars
- Leila M
- 08-29-24
Fantastic!
Prusiner is brilliant. He has drive, passion, fortitude. He kept going, even when other scientists denigrated his work, and absolutely refused to believe prions existed. Highly recommend this book.
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Overall5 out of 5 stars
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Performance5 out of 5 stars
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Story5 out of 5 stars
- jaime gonzalez
- 05-28-21
Prions a ground breaking discovery
Fascinating review of a Nobel laureate’s journey to the discovery of prions.Highly recommend the book.
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