Life's Greatest Secret
The Race to Crack the Genetic Code
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Life's Greatest Secret
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Narrated by:
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John Lee
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By:
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Matthew Cobb
About this listen
Everyone has heard the story of DNA as the story of Watson, Crick, and Rosalind Franklin, but knowing the structure of DNA was only part of a greater struggle to understand life's secrets. Life's Greatest Secret is the story of the discovery and cracking of the genetic code, the thing that ultimately enables a spiraling molecule to give rise to the life that exists all around us. This great scientific breakthrough has had far-reaching consequences for how we understand ourselves and our place in the natural world and for how we might take control of our (and life's) future.
Life's Greatest Secret mixes remarkable insights, theoretical dead ends, and ingenious experiments with the swift pace of a thriller. From New York to Paris; Cambridge, Massachusetts, to Cambridge, England; and London to Moscow, the greatest discovery of 20th-century biology was truly a global feat. Biologist and historian of science Matthew Cobb gives the full and rich account of the cooperation and competition between the eccentric characters who contributed to this revolutionary new science. And, while every new discovery was a leap forward for science, Cobb shows how every new answer inevitably led to new questions that were at least as difficult to answer. But the setbacks and unexpected discoveries are what make the science exciting. This is a riveting story of humans exploring what it is that makes us human and how the world works.
©2015 Matthew Cobb (P)2015 Tantor AudioListeners also enjoyed...
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A Crack in Creation
- Gene Editing and the Unthinkable Power to Control Evolution
- By: Jennifer A. Doudna, Samuel H. Sternberg
- Narrated by: Erin Bennett
- Length: 9 hrs and 22 mins
- Unabridged
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Overall4.5 out of 5 stars 1,360
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Performance4.5 out of 5 stars 1,162
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Story4.5 out of 5 stars 1,161
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.
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5 out of 5 stars
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In to the abyss we ascend, a scary future
- By Philomath on 06-17-17
By: Jennifer A. Doudna, and others
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13 Things That Don't Make Sense
- The Most Baffling Scientific Mysteries of Our Time
- By: Michael Brooks
- Narrated by: James Adams
- Length: 8 hrs and 58 mins
- Unabridged
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Overall4 out of 5 stars 2,565
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Performance4 out of 5 stars 1,560
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Story4 out of 5 stars 1,564
Science starts to get interesting when things don't make sense. Science's best-kept secret is that there are experimental results and reliable data that the most brilliant scientists can neither explain nor dismiss. If history is any precedent, we should look to today's inexplicable results to forecast the future of science. Michael Brooks heads to the scientific frontier to meet 13 modern-day anomalies and discover tomorrow's breakthroughs.
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4 out of 5 stars
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10 interesting chapters-read epiloge first
- By Stephen on 06-10-09
By: Michael Brooks
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Know This
- Today's Most Interesting and Important Scientific Ideas, Discoveries, and Developments
- By: John Brockman
- Narrated by: Gabra Zackman, Dan John Miller
- Length: 14 hrs and 39 mins
- Unabridged
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Overall4 out of 5 stars 232
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Performance4 out of 5 stars 204
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Story4 out of 5 stars 201
Scientific developments radically alter our understanding of the world. Whether it's technology, climate change, health research, or the latest revelations of neuroscience, physics, or psychology, science has, as Edge editor John Brockman says, "become a big story, if not the big story". In that spirit this new addition to Edge.org's fascinating series asks a powerful and provocative question: What do you consider the most interesting and important recent scientific news?
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1 out of 5 stars
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Pete and Repeat and Re-repeat
- By Daniel L on 02-25-18
By: John Brockman
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At the Edge of Uncertainty
- 11 Discoveries Taking Science by Surprise
- By: Michael Brooks
- Narrated by: Sean Runnette
- Length: 9 hrs and 12 mins
- Unabridged
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Overall4 out of 5 stars 1,201
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Performance4.5 out of 5 stars 1,085
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Story4.5 out of 5 stars 1,084
The atom, the big bang, DNA, natural selection - all are ideas that have revolutionized science; and all were dismissed out of hand when they first appeared. The surprises haven't stopped in recent years, and in At the Edge of Uncertainty, best-selling author Michael Brooks investigates the new wave of radical insights that are shaping the future of scientific discovery.
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1 out of 5 stars
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All smoke, no fire
- By Kenton on 07-25-15
By: Michael Brooks
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The Gene
- An Intimate History
- By: Siddhartha Mukherjee
- Narrated by: Dennis Boutsikaris
- Length: 19 hrs and 22 mins
- Unabridged
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Overall4.5 out of 5 stars 5,893
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Performance4.5 out of 5 stars 5,171
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Story4.5 out of 5 stars 5,124
The extraordinary Siddhartha Mukherjee has written a biography of the gene as deft, brilliant, and illuminating as his extraordinarily successful biography of cancer. Weaving science, social history, and personal narrative to tell us the story of one of the most important conceptual breakthroughs of modern times, Mukherjee animates the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.
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5 out of 5 stars
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It's a Wonderful Book
- By JKC on 06-02-16
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What Is Life?
- How Chemistry Becomes Biology
- By: Addy Pross
- Narrated by: Derek Perkins
- Length: 6 hrs and 50 mins
- Unabridged
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Overall4 out of 5 stars 643
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Performance4.5 out of 5 stars 562
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Story4 out of 5 stars 560
Seventy years ago, Erwin Schrdinger posed a simple, yet profound, question: What is life?. How could the very existence of such extraordinary chemical systems be understood? This problem has puzzled biologists and physical scientists both before, and ever since. Living things are hugely complex and have unique properties, such as self-maintenance and apparently purposeful behaviour which we do not see in inert matter. So how does chemistry give rise to biology?
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5 out of 5 stars
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Profound & Life Changing...
- By Daegan Smith on 04-06-15
By: Addy Pross
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Undeniable
- How Biology Confirms Our Intuition That Life Is Designed
- By: Douglas Axe
- Narrated by: Neil Hellegers
- Length: 7 hrs and 14 mins
- Unabridged
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Overall4.5 out of 5 stars 311
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Performance4.5 out of 5 stars 273
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Story4.5 out of 5 stars 272
Throughout his distinguished and unconventional career, engineer-turned-molecular-biologist Douglas Axe has been asking the questions that much of the scientific community would rather silence. Now, he presents his conclusions in this brave and pioneering book. Axe argues that the key to understanding our origin is the "design intuition" - the innate belief held by all humans that tasks we would need knowledge to accomplish can be accomplished only by someone who has that knowledge.
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5 out of 5 stars
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Seductively Challenge what are consider facts
- By Rafael Vila on 10-08-16
By: Douglas Axe
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p53: The Gene That Cracked the Cancer Code
- By: Sue Armstrong
- Narrated by: Elizabeth Jasicki
- Length: 9 hrs and 55 mins
- Unabridged
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Overall4.5 out of 5 stars 125
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Performance4 out of 5 stars 109
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Story4.5 out of 5 stars 107
p53: The Gene That Cracked the Cancer Code reveals the tale of the search for this gene, as well as the excitement of the hunt for new cures - the hype, the lost opportunities, the blind alleys, and the thrilling breakthroughs. As the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms starts to take off at last, p53 is still at the forefront of the game. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.
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5 out of 5 stars
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Excellent story! Unfortunate narration at start
- By Adriana on 12-25-14
By: Sue Armstrong
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The Story of Western Science
- From the Writings of Aristotle to the Big Bang Theory
- By: Susan Wise Bauer
- Narrated by: Julian Elfer
- Length: 8 hrs and 3 mins
- Unabridged
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Overall4.5 out of 5 stars 291
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Performance4.5 out of 5 stars 248
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Story4.5 out of 5 stars 253
Far too often, public discussion of science is carried out by journalists, voters, and politicians who have received their science secondhand. The Story of Western Science shows us the joy and importance of reading groundbreaking science writing for ourselves and guides us back to the masterpieces that have changed the way we think about our world, our cosmos, and ourselves.
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4 out of 5 stars
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Good text, tedious book structure
- By Diane K. on 10-07-15
By: Susan Wise Bauer
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Entangled Minds
- Extrasensory Experiences in a Quantum Reality
- By: Dean Radin PhD
- Narrated by: Al Kessel
- Length: 9 hrs and 25 mins
- Unabridged
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Overall4.5 out of 5 stars 175
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Performance4.5 out of 5 stars 149
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Story4.5 out of 5 stars 149
Is everything connected? Can we sense what's happening to loved ones thousands of miles away? Why are we sometimes certain of a caller's identity the instant the phone rings? Do intuitive hunches contain information about future events? Is it possible to perceive without the use of the ordinary senses? Many people believe that such "psychic phenomena" are rare talents or divine gifts. Others don't believe they exist at all. But the latest scientific research shows that these phenomena are both real and widespread.
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4 out of 5 stars
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Boring as all get out but…
- By rebekah higgins on 01-12-20
By: Dean Radin PhD
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The Vital Question
- Energy, Evolution, and the Origins of Complex Life
- By: Nick Lane
- Narrated by: Kevin Pariseau
- Length: 11 hrs and 27 mins
- Unabridged
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Overall4.5 out of 5 stars 1,176
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Performance4.5 out of 5 stars 1,041
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Story4.5 out of 5 stars 1,030
The Earth teems with life: in its oceans, forests, skies, and cities. Yet there's a black hole at the heart of biology. We do not know why complex life is the way it is, or, for that matter, how life first began. In The Vital Question, award-winning author and biochemist Nick Lane radically reframes evolutionary history, putting forward a solution to conundrums that have puzzled generations of scientists.
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4 out of 5 stars
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Ouch!
- By Mark on 06-24-16
By: Nick Lane
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Rigor Mortis
- How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions
- By: Richard Harris
- Narrated by: Joe Delafield
- Length: 5 hrs and 56 mins
- Unabridged
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Overall4.5 out of 5 stars 117
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Performance4.5 out of 5 stars 100
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Story4.5 out of 5 stars 99
American taxpayers spend $30 billion annually funding biomedical research, but over half of these studies can't be replicated due to poor experimental design, improper methods, and sloppy statistics. Bad science doesn't just hold back medical progress, it can sign the equivalent of a death sentence for terminal patients. In Rigor Mortis, Richard Harris explores these urgent issues with vivid anecdotes, personal stories, and interviews with the top biomedical researchers. We need to fix our dysfunctional biomedical system - before it's too late.
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5 out of 5 stars
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Eye opening introduction to biomedical R&D
- By Amazon Customer on 09-18-18
By: Richard Harris
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The Structure of Scientific Revolutions
- By: Thomas S. Kuhn
- Narrated by: Dennis Holland
- Length: 10 hrs and 14 mins
- Unabridged
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Overall4 out of 5 stars 1,152
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Performance4 out of 5 stars 830
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Story4 out of 5 stars 812
A good book may have the power to change the way we see the world, but a great book actually becomes part of our daily consciousness, pervading our thinking to the point that we take it for granted, and we forget how provocative and challenging its ideas once were - and still are. The Structure of Scientific Revolutions is that kind of book.
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3 out of 5 stars
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The problem is not with the book
- By Marcus on 08-09-09
By: Thomas S. Kuhn
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The Book of Why
- The New Science of Cause and Effect
- By: Judea Pearl, Dana Mackenzie
- Narrated by: Mel Foster
- Length: 15 hrs and 14 mins
- Unabridged
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Overall4.5 out of 5 stars 833
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Performance4.5 out of 5 stars 690
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Story4.5 out of 5 stars 688
"Correlation does not imply causation". This mantra has been invoked by scientists for decades and has led to a virtual prohibition on causal talk. But today, that taboo is dead. The causal revolution, sparked by Judea Pearl and his colleagues, has cut through a century of confusion and placed causality - the study of cause and effect - on a firm scientific basis.
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5 out of 5 stars
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Great book! Not a great audiobook.
- By rrwright on 05-30-18
By: Judea Pearl, and others
What listeners say about Life's Greatest Secret
Average customer ratingsReviews - Please select the tabs below to change the source of reviews.
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Overall3 out of 5 stars
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Performance5 out of 5 stars
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Story3 out of 5 stars
- Michael A. Kelley
- 09-03-15
Where does the science end?
Is there anything you would change about this book?
The book is meticulously researched and presents a great history of the cracking of the Genetic Code; however, the author's insistence of mixing in his own philosophy and interpretations were a bit frustrating. To me, the story and the author's input really confirm the genius of the Thomas Kuhn.
Which character – as performed by John Lee – was your favorite?
John Lee's performance was one of the best that I have ever listened to.
Could you see Life's Greatest Secret being made into a movie or a TV series? Who should the stars be?
No - the information was way to technical.
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1 person found this helpful
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Overall5 out of 5 stars
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Performance5 out of 5 stars
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Story5 out of 5 stars
- Rodney Brown
- 09-30-15
Fascinating!
If you could sum up Life's Greatest Secret in three words, what would they be?
Fascinating, meticulous research
Which scene was your favorite?
n/a
Any additional comments?
"Life's Greatest Secret: The Race to Crack the Genetic Code" is not an easy read, but the author knows is subject matter thoroughly and writes in a clear and understandable manner. If you have any interest in molecular genetics it's a "must read".
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2 people found this helpful
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Overall5 out of 5 stars
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Performance5 out of 5 stars
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Story5 out of 5 stars
- Beth Purkhiser
- 09-15-21
Comprehensive and informative
As a molecular biologist, I was impressed with Cobb's research into the chain of events which lead up to the mapping of the human genome. He discussed the contributions of scientists I was unfamiliar with. Very well done!
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Overall4 out of 5 stars
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Performance3 out of 5 stars
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Story4 out of 5 stars
- adam
- 08-18-15
Narrator is terrible for American audience
Interesting book geared to those with a serious background in the subject. The narrator's accent is very difficult to understand for an American audience especially with the very technical material which this book deals with.
Recommended only for those with a serious interest in the subject.
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3 people found this helpful