Good Genes Gone Bad
A Short History of Vaccines and Biologics: Failures, Successes, Controversies
Failed to add items
Add to Cart failed.
Add to Wish List failed.
Remove from wishlist failed.
Adding to library failed
Follow podcast failed
Unfollow podcast failed
Prime members: New to Audible?Get 2 free audiobooks during trial.
Good Genes Gone Bad
Buy for $15.75
No default payment method selected.
We are sorry. We are not allowed to sell this product with the selected payment method
-
Narrated by:
-
Mishal Varma
About this listen
The field of biotechnology has evolved over the past four decades, developing medicines which are curing diseases. But this journey of success has been tough and arduous, built upon the shoulders of major failures.
Good Genes Gone Bad highlights seven such colossal failures in drug development - all of which culminated in the development of novel drugs - weaving together various analogies through the stories and thus allowing the reader to understand complex biological phenomena. These stories include treatment of medical conditions such as genetic clotting disorder (haemophilia), childhood-diarrhoea (rotavirus vaccine), preventing HIV infection, activation of the immune systems to treat cancer, gene therapy for treatment of diseases caused by gene-defects/mutations, cell therapy for treatment of leukaemias, and finally the success of Biocon's approval of the first biologic drug for breast cancer.
Written by the former R&D head of Biocon, India's largest pharmaceutical company, Good Genes Gone Bad is a fascinating look at the complex world of medicine and drug development, providing the readers with a sense of magnitude of challenges and the extent of difficulty that it takes to make novel medicines.
©2021 Narendra Chirmule (P)2022 Random House AudioListeners also enjoyed...
-
The Emperor of All Maladies
- A Biography of Cancer
- By: Siddhartha Mukherjee
- Narrated by: Fred Sanders
- Length: 22 hrs and 18 mins
- Unabridged
-
Overall5 out of 5 stars 4,689
-
Performance5 out of 5 stars 4,110
-
Story5 out of 5 stars 4,088
The Emperor of All Maladies reveals the many faces of an iconic, shape-shifting disease that is the defining plague of our generation. The story of cancer is a story of human ingenuity, resilience, and perseverance but also of hubris, arrogance, paternalism, and misperception, all leveraged against a disease that, just three decades ago, was thought to be easily vanquished in an all-out "war against cancer".
-
5 out of 5 stars
-
Incredible
- By S.R.E. on 03-02-16
-
Deadliest Enemy
- Our War Against Killer Germs
- By: Michael T. Osterholm, Mark Olshaker, Michael T. Osterholm PhD MPH
- Narrated by: Jamie Renell
- Length: 11 hrs and 26 mins
- Unabridged
-
Overall5 out of 5 stars 1,373
-
Performance5 out of 5 stars 1,177
-
Story5 out of 5 stars 1,170
We are facing an overwhelming army of deadly, invisible enemies. We need a plan - before it's too late. Unlike natural disasters, whose destruction is concentrated in a limited area over a period of days, and illnesses, which have devastating effects but are limited to individuals and their families, infectious disease has the terrifying power to disrupt everyday life on a global scale, overwhelming public and private resources and bringing trade and transportation to a grinding halt.
-
5 out of 5 stars
-
Topical treatise on virus flu pandemics
- By Wayne on 03-15-20
By: Michael T. Osterholm, and others
-
A Crack in Creation
- Gene Editing and the Unthinkable Power to Control Evolution
- By: Jennifer A. Doudna, Samuel H. Sternberg
- Narrated by: Erin Bennett
- Length: 9 hrs and 22 mins
- Unabridged
-
Overall4.5 out of 5 stars 1,360
-
Performance4.5 out of 5 stars 1,162
-
Story4.5 out of 5 stars 1,161
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.
-
5 out of 5 stars
-
In to the abyss we ascend, a scary future
- By Philomath on 06-17-17
By: Jennifer A. Doudna, and others
-
Deep Medicine
- How Artificial Intelligence Can Make Healthcare Human Again
- By: Eric Topol
- Narrated by: Graham Winton
- Length: 11 hrs and 6 mins
- Unabridged
-
Overall4.5 out of 5 stars 757
-
Performance4.5 out of 5 stars 639
-
Story4.5 out of 5 stars 635
Medicine has become inhuman, to disastrous effect. The doctor-patient relationship - the heart of medicine - is broken: doctors are too distracted and overwhelmed to truly connect with their patients, and medical errors and misdiagnoses abound. In Deep Medicine, leading physician Eric Topol reveals how artificial intelligence can help. AI has the potential to transform everything doctors do, from notetaking and medical scans to diagnosis and treatment, greatly cutting down the cost of medicine and reducing human mortality.
-
5 out of 5 stars
-
a must book for all doctors and patients.
- By adva onn on 04-21-19
By: Eric Topol
-
Viruses, Plagues, and History
- Past, Present, and Future
- By: Michael B. A. Oldstone
- Narrated by: L.J. Ganser
- Length: 13 hrs and 38 mins
- Unabridged
-
Overall4.5 out of 5 stars 550
-
Performance4.5 out of 5 stars 467
-
Story4.5 out of 5 stars 467
The story of viruses and humanity is a story of fear and ignorance, of grief and heartbreak, and of great bravery and sacrifice. Michael Oldstone tells all these stories as he illuminates the history of the devastating diseases that have tormented humanity, focusing mostly on the most famous viruses. For this revised edition, Oldstone includes discussions of new viruses like SARS, bird flu, virally caused cancers, chronic wasting disease, and West Nile. Viruses, Plagues, and History paints a sweeping portrait of humanity's long-standing conflict with our unseen viral enemies.
-
4 out of 5 stars
-
very detailed, but very statistical
- By ekhensel15 on 01-12-19
-
The Drug Hunters
- The Improbable Quest to Discover New Medicines
- By: Donald R. Kirsch PhD, Ogi Ogas PhD
- Narrated by: James Foster
- Length: 7 hrs and 35 mins
- Unabridged
-
Overall4.5 out of 5 stars 1,177
-
Performance4.5 out of 5 stars 1,067
-
Story4.5 out of 5 stars 1,066
The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity - by chewing, brewing, and snorting - some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the 5,000-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze Age medicine, a worm-killing birch fungus, knotted to his leggings.
-
3 out of 5 stars
-
Aargh!
- By Curmud the prof on 05-20-17
By: Donald R. Kirsch PhD, and others
-
The Emperor of All Maladies
- A Biography of Cancer
- By: Siddhartha Mukherjee
- Narrated by: Fred Sanders
- Length: 22 hrs and 18 mins
- Unabridged
-
Overall5 out of 5 stars 4,689
-
Performance5 out of 5 stars 4,110
-
Story5 out of 5 stars 4,088
The Emperor of All Maladies reveals the many faces of an iconic, shape-shifting disease that is the defining plague of our generation. The story of cancer is a story of human ingenuity, resilience, and perseverance but also of hubris, arrogance, paternalism, and misperception, all leveraged against a disease that, just three decades ago, was thought to be easily vanquished in an all-out "war against cancer".
-
5 out of 5 stars
-
Incredible
- By S.R.E. on 03-02-16
-
Deadliest Enemy
- Our War Against Killer Germs
- By: Michael T. Osterholm, Mark Olshaker, Michael T. Osterholm PhD MPH
- Narrated by: Jamie Renell
- Length: 11 hrs and 26 mins
- Unabridged
-
Overall5 out of 5 stars 1,373
-
Performance5 out of 5 stars 1,177
-
Story5 out of 5 stars 1,170
We are facing an overwhelming army of deadly, invisible enemies. We need a plan - before it's too late. Unlike natural disasters, whose destruction is concentrated in a limited area over a period of days, and illnesses, which have devastating effects but are limited to individuals and their families, infectious disease has the terrifying power to disrupt everyday life on a global scale, overwhelming public and private resources and bringing trade and transportation to a grinding halt.
-
5 out of 5 stars
-
Topical treatise on virus flu pandemics
- By Wayne on 03-15-20
By: Michael T. Osterholm, and others
-
A Crack in Creation
- Gene Editing and the Unthinkable Power to Control Evolution
- By: Jennifer A. Doudna, Samuel H. Sternberg
- Narrated by: Erin Bennett
- Length: 9 hrs and 22 mins
- Unabridged
-
Overall4.5 out of 5 stars 1,360
-
Performance4.5 out of 5 stars 1,162
-
Story4.5 out of 5 stars 1,161
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.
-
5 out of 5 stars
-
In to the abyss we ascend, a scary future
- By Philomath on 06-17-17
By: Jennifer A. Doudna, and others
-
Deep Medicine
- How Artificial Intelligence Can Make Healthcare Human Again
- By: Eric Topol
- Narrated by: Graham Winton
- Length: 11 hrs and 6 mins
- Unabridged
-
Overall4.5 out of 5 stars 757
-
Performance4.5 out of 5 stars 639
-
Story4.5 out of 5 stars 635
Medicine has become inhuman, to disastrous effect. The doctor-patient relationship - the heart of medicine - is broken: doctors are too distracted and overwhelmed to truly connect with their patients, and medical errors and misdiagnoses abound. In Deep Medicine, leading physician Eric Topol reveals how artificial intelligence can help. AI has the potential to transform everything doctors do, from notetaking and medical scans to diagnosis and treatment, greatly cutting down the cost of medicine and reducing human mortality.
-
5 out of 5 stars
-
a must book for all doctors and patients.
- By adva onn on 04-21-19
By: Eric Topol
-
Viruses, Plagues, and History
- Past, Present, and Future
- By: Michael B. A. Oldstone
- Narrated by: L.J. Ganser
- Length: 13 hrs and 38 mins
- Unabridged
-
Overall4.5 out of 5 stars 550
-
Performance4.5 out of 5 stars 467
-
Story4.5 out of 5 stars 467
The story of viruses and humanity is a story of fear and ignorance, of grief and heartbreak, and of great bravery and sacrifice. Michael Oldstone tells all these stories as he illuminates the history of the devastating diseases that have tormented humanity, focusing mostly on the most famous viruses. For this revised edition, Oldstone includes discussions of new viruses like SARS, bird flu, virally caused cancers, chronic wasting disease, and West Nile. Viruses, Plagues, and History paints a sweeping portrait of humanity's long-standing conflict with our unseen viral enemies.
-
4 out of 5 stars
-
very detailed, but very statistical
- By ekhensel15 on 01-12-19
-
The Drug Hunters
- The Improbable Quest to Discover New Medicines
- By: Donald R. Kirsch PhD, Ogi Ogas PhD
- Narrated by: James Foster
- Length: 7 hrs and 35 mins
- Unabridged
-
Overall4.5 out of 5 stars 1,177
-
Performance4.5 out of 5 stars 1,067
-
Story4.5 out of 5 stars 1,066
The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity - by chewing, brewing, and snorting - some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the 5,000-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze Age medicine, a worm-killing birch fungus, knotted to his leggings.
-
3 out of 5 stars
-
Aargh!
- By Curmud the prof on 05-20-17
By: Donald R. Kirsch PhD, and others
-
Vaccines, Autoimmunity, and the Changing Nature of Childhood Illness
- By: Thomas Cowan MD
- Narrated by: Madison Niederhauser
- Length: 4 hrs and 17 mins
- Unabridged
-
Overall5 out of 5 stars 474
-
Performance5 out of 5 stars 413
-
Story5 out of 5 stars 409
Over the past 50 years, rates of autoimmunity and chronic disease have exploded. In this provocative book, Dr. Thomas Cowan argues for a direct causal relationship to a corresponding increase in the number of vaccines American children typically receive. The goal of these vaccines is precisely what we’re now seeing in such abundance among our chronically ill children: the provocation of immune response. Cowan looks at emerging evidence that certain childhood illnesses are actually protective of disease later in life.
-
5 out of 5 stars
-
Hear both sides
- By SJ on 01-24-20
By: Thomas Cowan MD
-
Tripping Over the Truth
- The Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure
- By: Travis Christofferson
- Narrated by: Clay Lomakayu
- Length: 9 hrs and 38 mins
- Unabridged
-
Overall5 out of 5 stars 588
-
Performance4.5 out of 5 stars 519
-
Story5 out of 5 stars 513
A masterful synchronization of history and cutting-edge science shines new light on humanity's darkest diagnosis. In the wake of the Cancer Genome Atlas project's failure to provide a legible road map to a cure for cancer, science writer Travis Christofferson illuminates a promising blend of old and new perspectives on the disease.
-
5 out of 5 stars
-
Non-fiction books - please include references
- By yaelb on 06-15-16
-
Influenza
- The Hundred-Year Hunt to Cure the 1918 Spanish Flu Pandemic
- By: Dr. Jeremy Brown
- Narrated by: Holter Graham
- Length: 6 hrs and 28 mins
- Unabridged
-
Overall4.5 out of 5 stars 361
-
Performance4.5 out of 5 stars 309
-
Story4.5 out of 5 stars 307
On the 100th anniversary of the devastating pandemic of 1918, Jeremy Brown, a veteran ER doctor, explores the troubling, terrifying, and complex history of the flu virus, from the origins of the Great Flu that killed millions, to vexing questions such as: are we prepared for the next epidemic, should you get a flu shot, and how close are we to finding a cure?
-
5 out of 5 stars
-
Important read
- By Kathryn C. on 12-21-18
By: Dr. Jeremy Brown
-
Longshot
- The Inside Story of the Race for a COVID-19 Vaccine
- By: David Heath
- Narrated by: David Heath, Eric Jason Martin
- Length: 8 hrs
- Unabridged
-
Overall5 out of 5 stars 30
-
Performance5 out of 5 stars 27
-
Story5 out of 5 stars 27
In Longshot, investigative journalist David Heath takes listeners inside the small group of scientists whose groundbreaking work was once largely dismissed but whose feat will now eclipse the importance of Jonas Salk’s polio vaccine in medical history. With never-before-reported details, Heath reveals how these scientists overcame countless obstacles to give the world an unprecedented head start when we needed a COVID-19 vaccine.
-
5 out of 5 stars
-
Facts.
- By Theresa D. Fellmann on 04-06-24
By: David Heath
-
The HPV Vaccine on Trial
- Seeking Justice for a Generation Betrayed
- By: Mary Holland, Kim Mack Rosenberg, Eileen Iorio
- Narrated by: Caroline Slaughter
- Length: 13 hrs and 41 mins
- Unabridged
-
Overall5 out of 5 stars 58
-
Performance5 out of 5 stars 50
-
Story5 out of 5 stars 51
Cancer strikes fear in people’s hearts around globe. So the appearance of a vaccine to prevent cancer - as we are assured the human papillomavirus (HPV) vaccine will - seemed like a game-changer. Since 2006, over 80 countries have approved the vaccine, with glowing endorsements from the world’s foremost medical authorities. Bringing in over $2.5 billion in annual sales, the HPV vaccine is a pharmaceutical juggernaut. Yet scandal now engulfs it worldwide. The HPV Vaccine on Trial is a shocking tale, chronicling the global efforts to sell and compel this alleged miracle.
-
5 out of 5 stars
-
Outstanding Investigative Book!
- By Barbara Loeppke on 10-02-19
By: Mary Holland, and others
-
The Genome Odyssey
- Medical Mysteries and the Incredible Quest to Solve Them
- By: Dr. Euan Angus Ashley
- Narrated by: Dr. Euan Angus Ashley
- Length: 10 hrs and 39 mins
- Unabridged
-
Overall5 out of 5 stars 63
-
Performance5 out of 5 stars 55
-
Story5 out of 5 stars 54
In The Genome Odyssey, Dr. Euan Ashley, Stanford professor of medicine and genetics, brings the breakthroughs of precision medicine to vivid life through the real diagnostic journeys of his patients and the tireless efforts of his fellow doctors and scientists as they hunt to prevent, predict, and beat disease.
-
2 out of 5 stars
-
Interesting at times but repetitive, badly written
- By kenissur on 07-11-22
-
Vaccinated
- From Cowpox to mRNA, the Remarkable Story of Vaccines
- By: Paul A. Offit
- Narrated by: Tim Dixon
- Length: 8 hrs and 29 mins
- Unabridged
-
Overall5 out of 5 stars 50
-
Performance5 out of 5 stars 47
-
Story5 out of 5 stars 47
Respected physician Paul Offit tells a fascinating story of modern medicine and pays tribute to one of the greatest lifesaving breakthroughs—vaccinations—and the medical hero responsible for developing nine of the big fourteen vaccines which have saved billions of lives worldwide.
-
5 out of 5 stars
-
Must read for pediatric professionals and public health professional
- By laithejeilat on 04-15-24
By: Paul A. Offit
-
The Breakthrough
- Immunotherapy and the Race to Cure Cancer
- By: Charles Graeber
- Narrated by: Will Collyer, Charles Graeber
- Length: 7 hrs and 7 mins
- Unabridged
-
Overall4.5 out of 5 stars 517
-
Performance4.5 out of 5 stars 461
-
Story4.5 out of 5 stars 459
Groundbreaking, riveting, and expertly told, The Breakthrough is the story of the game-changing scientific discoveries that unleash our natural ability to recognize and defeat cancer, as told through the experiences of the patients, physicians, and cancer immunotherapy researchers who are on the front lines. This is the incredible true story of the race to find a cure, a dispatch from the life-changing world of modern oncological science, and a brave new chapter in medical history.
-
5 out of 5 stars
-
Surprisingly gripping
- By Kari Niles on 01-21-19
By: Charles Graeber
-
Thimerosal: Let the Science Speak
- The Evidence Supporting the Immediate Removal of Mercury - a Known Neurotoxin - from Vaccines
- By: Robert F. Kennedy - editor
- Narrated by: James Patrick Cronin
- Length: 4 hrs and 42 mins
- Unabridged
-
Overall5 out of 5 stars 61
-
Performance5 out of 5 stars 48
-
Story4.5 out of 5 stars 47
From New York Times best-selling author Robert F. Kennedy, Jr., comes a science-based call for the immediate removal of the dangerous mercury-containing preservative Thimerosal from vaccines. Over a decade ago, following a sharp rise in developmental disorders such as autism and ADHD, the mercury-containing preservative Thimerosal was widely believed to have been eliminated from vaccine supplies in the United States and abroad.
-
5 out of 5 stars
-
Challenging to listen to, but worth it
- By GP on 10-03-15
-
The Inflamed Mind
- A Radical New Approach to Depression
- By: Edward Bullmore
- Narrated by: Sean Patrick Hopkins, Edward Bullmore - foreword
- Length: 6 hrs and 25 mins
- Unabridged
-
Overall4.5 out of 5 stars 119
-
Performance4.5 out of 5 stars 106
-
Story4.5 out of 5 stars 105
University of Cambridge profressor of psychiatry Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation of the body and brain. He explains how and why we now know that mental disorders can have their root cause in the immune system, and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycles of stress, inflammation, and depression. The Inflamed Mind goes far beyond the clinic and the lab, representing a whole new way of looking at how mind, brain, and body all work together.
-
4 out of 5 stars
-
I can relate as a suffer
- By Robert S. on 01-25-19
By: Edward Bullmore
-
The Truth About Cancer
- By: Ty M. Bollinger
- Narrated by: Ty M. Bollinger
- Length: 9 hrs and 11 mins
- Unabridged
-
Overall4.5 out of 5 stars 318
-
Performance4.5 out of 5 stars 276
-
Story4.5 out of 5 stars 275
One out of three women alive today, and one out of two men, will face a cancer diagnosis, according to the World Health Organization. Ty Bollinger takes this personally: in the course of a decade, he says, "I lost my entire family to cancer. I don't believe I had to lose them." The Truth about Cancer has been written for one simple reason: to share the knowledge we need to protect ourselves, treat ourselves, and in some cases save our lives or the lives of those we love.
-
5 out of 5 stars
-
save a life with this valuable information.
- By edwin matias on 12-30-16
By: Ty M. Bollinger
-
Biography of Resistance
- The Epic Battle Between People and Pathogens
- By: Muhammad H. Zaman
- Narrated by: Kyle Tait
- Length: 8 hrs and 3 mins
- Unabridged
-
Overall4.5 out of 5 stars 419
-
Performance4.5 out of 5 stars 354
-
Story4.5 out of 5 stars 355
In September 2016, a woman in Nevada became the first known case in the US of a person who died of an infection resistant to every antibiotic available. Her death is the worst nightmare of infectious disease doctors and public health professionals. While bacteria live within us and are essential for our health, some strains can kill us. As bacteria continue to mutate, becoming increasingly resistant to known antibiotics, we are likely to face a public health crisis of unimaginable proportions.
-
5 out of 5 stars
-
Excellent read for a complicated issue
- By Anonymous User on 05-03-20
Related to this topic
-
A Crack in Creation
- Gene Editing and the Unthinkable Power to Control Evolution
- By: Jennifer A. Doudna, Samuel H. Sternberg
- Narrated by: Erin Bennett
- Length: 9 hrs and 22 mins
- Unabridged
-
Overall4.5 out of 5 stars 1,360
-
Performance4.5 out of 5 stars 1,162
-
Story4.5 out of 5 stars 1,161
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.
-
5 out of 5 stars
-
In to the abyss we ascend, a scary future
- By Philomath on 06-17-17
By: Jennifer A. Doudna, and others
-
The Language of Life
- DNA and the Revolution in Personalized Medicine
- By: Francis S. Collins
- Narrated by: Greg Itzin
- Length: 10 hrs and 45 mins
- Unabridged
-
Overall4 out of 5 stars 148
-
Performance4.5 out of 5 stars 99
-
Story4 out of 5 stars 97
A scientific and medical revolution has crept up on us, based on study after study, from hundreds of laboratories around the world. It is no longer just a theoretical shift: every one of us will be touched by it, and many of us already have been. The meaning of disease, our understanding of the human body, and crucial decisions about what we all need to know and what choices we make about our health are at stake. Welcome to the new world of personalized medicine.
-
5 out of 5 stars
-
The future of medicine
- By Ronald E on 04-12-10
-
Happy Accidents
- Serendipity in Major Medical Breakthroughs in the Twentieth Century
- By: Morton A. Meyers
- Narrated by: Richard Waterhouse
- Length: 12 hrs and 37 mins
- Unabridged
-
Overall4.5 out of 5 stars 50
-
Performance4 out of 5 stars 45
-
Story4.5 out of 5 stars 44
Happy Accidents is a fascinating, entertaining, and highly accessible look at the surprising role serendipity has played in some of the most important medical discoveries in the 20th century. What do penicillin, chemotherapy drugs, X-rays, Valium, the Pap smear, and Viagra have in common? They were each discovered accidentally, stumbled upon in the search for something else. In discussing medical breakthroughs, Dr. Morton Meyers makes a cogent, highly engaging argument for a more creative, rather than purely linear, approach to science. And it may just save our lives!
-
1 out of 5 stars
-
Don't waste your money!
- By Amazon Customer on 03-20-16
By: Morton A. Meyers
-
Viruses, Plagues, and History
- Past, Present, and Future
- By: Michael B. A. Oldstone
- Narrated by: L.J. Ganser
- Length: 13 hrs and 38 mins
- Unabridged
-
Overall4.5 out of 5 stars 550
-
Performance4.5 out of 5 stars 467
-
Story4.5 out of 5 stars 467
The story of viruses and humanity is a story of fear and ignorance, of grief and heartbreak, and of great bravery and sacrifice. Michael Oldstone tells all these stories as he illuminates the history of the devastating diseases that have tormented humanity, focusing mostly on the most famous viruses. For this revised edition, Oldstone includes discussions of new viruses like SARS, bird flu, virally caused cancers, chronic wasting disease, and West Nile. Viruses, Plagues, and History paints a sweeping portrait of humanity's long-standing conflict with our unseen viral enemies.
-
4 out of 5 stars
-
very detailed, but very statistical
- By ekhensel15 on 01-12-19
-
p53: The Gene That Cracked the Cancer Code
- By: Sue Armstrong
- Narrated by: Elizabeth Jasicki
- Length: 9 hrs and 55 mins
- Unabridged
-
Overall4.5 out of 5 stars 125
-
Performance4 out of 5 stars 109
-
Story4.5 out of 5 stars 107
p53: The Gene That Cracked the Cancer Code reveals the tale of the search for this gene, as well as the excitement of the hunt for new cures - the hype, the lost opportunities, the blind alleys, and the thrilling breakthroughs. As the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms starts to take off at last, p53 is still at the forefront of the game. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.
-
5 out of 5 stars
-
Excellent story! Unfortunate narration at start
- By Adriana on 12-25-14
By: Sue Armstrong
-
The Compatibility Gene
- How Our Bodies Fight Disease, Attract Others, and Define Our Selves
- By: Daniel M. Davis
- Narrated by: Christopher Grove
- Length: 7 hrs and 48 mins
- Unabridged
-
Overall4.5 out of 5 stars 52
-
Performance4.5 out of 5 stars 42
-
Story4.5 out of 5 stars 42
Most of the 25,000 genes we possess are the same for all of us. Compatibility genes are those that vary most from person to person and give each of us a unique molecular signature. These genes determine both the extent to which we are susceptible to a vast range of illnesses and the different ways each of us fights disease.
-
5 out of 5 stars
-
If interested in medicine, got to read
- By Howard Sterling on 06-29-16
By: Daniel M. Davis
-
A Crack in Creation
- Gene Editing and the Unthinkable Power to Control Evolution
- By: Jennifer A. Doudna, Samuel H. Sternberg
- Narrated by: Erin Bennett
- Length: 9 hrs and 22 mins
- Unabridged
-
Overall4.5 out of 5 stars 1,360
-
Performance4.5 out of 5 stars 1,162
-
Story4.5 out of 5 stars 1,161
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.
-
5 out of 5 stars
-
In to the abyss we ascend, a scary future
- By Philomath on 06-17-17
By: Jennifer A. Doudna, and others
-
The Language of Life
- DNA and the Revolution in Personalized Medicine
- By: Francis S. Collins
- Narrated by: Greg Itzin
- Length: 10 hrs and 45 mins
- Unabridged
-
Overall4 out of 5 stars 148
-
Performance4.5 out of 5 stars 99
-
Story4 out of 5 stars 97
A scientific and medical revolution has crept up on us, based on study after study, from hundreds of laboratories around the world. It is no longer just a theoretical shift: every one of us will be touched by it, and many of us already have been. The meaning of disease, our understanding of the human body, and crucial decisions about what we all need to know and what choices we make about our health are at stake. Welcome to the new world of personalized medicine.
-
5 out of 5 stars
-
The future of medicine
- By Ronald E on 04-12-10
-
Happy Accidents
- Serendipity in Major Medical Breakthroughs in the Twentieth Century
- By: Morton A. Meyers
- Narrated by: Richard Waterhouse
- Length: 12 hrs and 37 mins
- Unabridged
-
Overall4.5 out of 5 stars 50
-
Performance4 out of 5 stars 45
-
Story4.5 out of 5 stars 44
Happy Accidents is a fascinating, entertaining, and highly accessible look at the surprising role serendipity has played in some of the most important medical discoveries in the 20th century. What do penicillin, chemotherapy drugs, X-rays, Valium, the Pap smear, and Viagra have in common? They were each discovered accidentally, stumbled upon in the search for something else. In discussing medical breakthroughs, Dr. Morton Meyers makes a cogent, highly engaging argument for a more creative, rather than purely linear, approach to science. And it may just save our lives!
-
1 out of 5 stars
-
Don't waste your money!
- By Amazon Customer on 03-20-16
By: Morton A. Meyers
-
Viruses, Plagues, and History
- Past, Present, and Future
- By: Michael B. A. Oldstone
- Narrated by: L.J. Ganser
- Length: 13 hrs and 38 mins
- Unabridged
-
Overall4.5 out of 5 stars 550
-
Performance4.5 out of 5 stars 467
-
Story4.5 out of 5 stars 467
The story of viruses and humanity is a story of fear and ignorance, of grief and heartbreak, and of great bravery and sacrifice. Michael Oldstone tells all these stories as he illuminates the history of the devastating diseases that have tormented humanity, focusing mostly on the most famous viruses. For this revised edition, Oldstone includes discussions of new viruses like SARS, bird flu, virally caused cancers, chronic wasting disease, and West Nile. Viruses, Plagues, and History paints a sweeping portrait of humanity's long-standing conflict with our unseen viral enemies.
-
4 out of 5 stars
-
very detailed, but very statistical
- By ekhensel15 on 01-12-19
-
p53: The Gene That Cracked the Cancer Code
- By: Sue Armstrong
- Narrated by: Elizabeth Jasicki
- Length: 9 hrs and 55 mins
- Unabridged
-
Overall4.5 out of 5 stars 125
-
Performance4 out of 5 stars 109
-
Story4.5 out of 5 stars 107
p53: The Gene That Cracked the Cancer Code reveals the tale of the search for this gene, as well as the excitement of the hunt for new cures - the hype, the lost opportunities, the blind alleys, and the thrilling breakthroughs. As the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms starts to take off at last, p53 is still at the forefront of the game. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.
-
5 out of 5 stars
-
Excellent story! Unfortunate narration at start
- By Adriana on 12-25-14
By: Sue Armstrong
-
The Compatibility Gene
- How Our Bodies Fight Disease, Attract Others, and Define Our Selves
- By: Daniel M. Davis
- Narrated by: Christopher Grove
- Length: 7 hrs and 48 mins
- Unabridged
-
Overall4.5 out of 5 stars 52
-
Performance4.5 out of 5 stars 42
-
Story4.5 out of 5 stars 42
Most of the 25,000 genes we possess are the same for all of us. Compatibility genes are those that vary most from person to person and give each of us a unique molecular signature. These genes determine both the extent to which we are susceptible to a vast range of illnesses and the different ways each of us fights disease.
-
5 out of 5 stars
-
If interested in medicine, got to read
- By Howard Sterling on 06-29-16
By: Daniel M. Davis
-
Between Hope and Fear
- A History of Vaccines and Human Immunity
- By: Michael Kinch
- Narrated by: Mel Foster
- Length: 15 hrs and 59 mins
- Unabridged
-
Overall4.5 out of 5 stars 40
-
Performance4.5 out of 5 stars 36
-
Story4.5 out of 5 stars 36
Between Hope and Fear tells the remarkable story of vaccine-preventable infectious diseases and their social and political implications. While detailing the history of vaccine invention, Michael Kinch reveals the ominous reality that our victories against vaccine-preventable diseases are not permanent - and could easily be undone. Between Hope and Fear relates the remarkable intersection of science, technology, and disease that has helped eradicate many of the deadliest plagues known to man.
-
4 out of 5 stars
-
Enjoyed
- By Minsi Zhang on 05-03-20
By: Michael Kinch
-
Editing Humanity
- The CRISPR Revolution and the New Era of Genome Editing
- By: Kevin Davies
- Narrated by: Kevin Davies
- Length: 16 hrs and 17 mins
- Unabridged
-
Overall4.5 out of 5 stars 76
-
Performance4.5 out of 5 stars 65
-
Story4.5 out of 5 stars 65
Engrossing and captivating, Editing Humanity takes listeners inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to edit the DNA of any organism down to the individual building blocks of the genetic code. Davies introduces listeners to arguably the most profound scientific breakthrough of our time. He tracks the scientists on the front lines of its research to the patients whose powerful stories bring the narrative movingly to human scale.
-
4 out of 5 stars
-
Excellent content, solid execution
- By Samuel Finlayson on 01-25-21
By: Kevin Davies
-
The Emperor of All Maladies
- A Biography of Cancer
- By: Siddhartha Mukherjee
- Narrated by: Fred Sanders
- Length: 22 hrs and 18 mins
- Unabridged
-
Overall5 out of 5 stars 4,689
-
Performance5 out of 5 stars 4,110
-
Story5 out of 5 stars 4,088
The Emperor of All Maladies reveals the many faces of an iconic, shape-shifting disease that is the defining plague of our generation. The story of cancer is a story of human ingenuity, resilience, and perseverance but also of hubris, arrogance, paternalism, and misperception, all leveraged against a disease that, just three decades ago, was thought to be easily vanquished in an all-out "war against cancer".
-
5 out of 5 stars
-
Incredible
- By S.R.E. on 03-02-16
-
Missing Microbes
- How the Overuse of Antibiotics Is Fueling Our Modern Plagues
- By: Martin J. Blaser
- Narrated by: Patrick Lawlor
- Length: 8 hrs and 43 mins
- Unabridged
-
Overall4.5 out of 5 stars 379
-
Performance4.5 out of 5 stars 322
-
Story4.5 out of 5 stars 324
In Missing Microbes, Dr. Martin J. Blaser invites us into the wilds of the human microbiome, where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the health and equilibrium of our body. Now this invisible eden is being irrevocably damaged by some of our most revered medical advances-antibiotics-threatening the extinction of our irreplaceable microbes with terrible health consequences.
-
5 out of 5 stars
-
Very enlightening and information well supported
- By James on 05-03-15
By: Martin J. Blaser
-
The Truth About Cancer
- By: Ty M. Bollinger
- Narrated by: Ty M. Bollinger
- Length: 9 hrs and 11 mins
- Unabridged
-
Overall4.5 out of 5 stars 318
-
Performance4.5 out of 5 stars 276
-
Story4.5 out of 5 stars 275
One out of three women alive today, and one out of two men, will face a cancer diagnosis, according to the World Health Organization. Ty Bollinger takes this personally: in the course of a decade, he says, "I lost my entire family to cancer. I don't believe I had to lose them." The Truth about Cancer has been written for one simple reason: to share the knowledge we need to protect ourselves, treat ourselves, and in some cases save our lives or the lives of those we love.
-
5 out of 5 stars
-
save a life with this valuable information.
- By edwin matias on 12-30-16
By: Ty M. Bollinger
-
Influenza
- The Hundred-Year Hunt to Cure the 1918 Spanish Flu Pandemic
- By: Dr. Jeremy Brown
- Narrated by: Holter Graham
- Length: 6 hrs and 28 mins
- Unabridged
-
Overall4.5 out of 5 stars 361
-
Performance4.5 out of 5 stars 309
-
Story4.5 out of 5 stars 307
On the 100th anniversary of the devastating pandemic of 1918, Jeremy Brown, a veteran ER doctor, explores the troubling, terrifying, and complex history of the flu virus, from the origins of the Great Flu that killed millions, to vexing questions such as: are we prepared for the next epidemic, should you get a flu shot, and how close are we to finding a cure?
-
5 out of 5 stars
-
Important read
- By Kathryn C. on 12-21-18
By: Dr. Jeremy Brown
-
An Epidemic of Absence
- A New Way of Understanding Allergies and Autoimmune Diseases
- By: Moises Velasquez-Manoff
- Narrated by: Chris Sorensen
- Length: 17 hrs and 6 mins
- Unabridged
-
Overall4.5 out of 5 stars 55
-
Performance4.5 out of 5 stars 48
-
Story4.5 out of 5 stars 49
An Epidemic of Absence asks what will happen in developing countries, which, as they become more affluent, have already seen an uptick in allergic disease: Will India end up more allergic than Europe? Velasquez-Manoff also details a controversial underground movement that has coalesced around the treatment of immune-mediated disorders with parasites. Against much of his better judgment, he joins these do-it-yourselfers and reports his surprising results.
-
5 out of 5 stars
-
The point of view from a Veterinarian immunologist
- By rtgymnast on 11-03-17
-
The HPV Vaccine on Trial
- Seeking Justice for a Generation Betrayed
- By: Mary Holland, Kim Mack Rosenberg, Eileen Iorio
- Narrated by: Caroline Slaughter
- Length: 13 hrs and 41 mins
- Unabridged
-
Overall5 out of 5 stars 58
-
Performance5 out of 5 stars 50
-
Story5 out of 5 stars 51
Cancer strikes fear in people’s hearts around globe. So the appearance of a vaccine to prevent cancer - as we are assured the human papillomavirus (HPV) vaccine will - seemed like a game-changer. Since 2006, over 80 countries have approved the vaccine, with glowing endorsements from the world’s foremost medical authorities. Bringing in over $2.5 billion in annual sales, the HPV vaccine is a pharmaceutical juggernaut. Yet scandal now engulfs it worldwide. The HPV Vaccine on Trial is a shocking tale, chronicling the global efforts to sell and compel this alleged miracle.
-
5 out of 5 stars
-
Outstanding Investigative Book!
- By Barbara Loeppke on 10-02-19
By: Mary Holland, and others
-
Rigor Mortis
- How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions
- By: Richard Harris
- Narrated by: Joe Delafield
- Length: 5 hrs and 56 mins
- Unabridged
-
Overall4.5 out of 5 stars 117
-
Performance4.5 out of 5 stars 100
-
Story4.5 out of 5 stars 99
American taxpayers spend $30 billion annually funding biomedical research, but over half of these studies can't be replicated due to poor experimental design, improper methods, and sloppy statistics. Bad science doesn't just hold back medical progress, it can sign the equivalent of a death sentence for terminal patients. In Rigor Mortis, Richard Harris explores these urgent issues with vivid anecdotes, personal stories, and interviews with the top biomedical researchers. We need to fix our dysfunctional biomedical system - before it's too late.
-
5 out of 5 stars
-
Eye opening introduction to biomedical R&D
- By Amazon Customer on 09-18-18
By: Richard Harris
-
Welcome to the Microbiome
- Getting to Know the Trillions of Bacteria and Other Microbes In, On, and Around You
- By: Rob DeSalle, Susan L. Perkins
- Narrated by: Stephen McLaughlin
- Length: 7 hrs and 25 mins
- Unabridged
-
Overall4.5 out of 5 stars 36
-
Performance4.5 out of 5 stars 35
-
Story4.5 out of 5 stars 34
Suddenly, research findings require a paradigm shift in our view of the microbial world. The Human Microbiome Project at the National Institutes of Health is well under way, and unprecedented scientific technology now allows the censusing of trillions of microbes inside and on our bodies as well as in the places where we live, work, and play. This intriguing, up-to-the-minute book for scientists and nonscientists alike explains what researchers are discovering about the microbe world and what the implications are for modern science and medicine.
-
5 out of 5 stars
-
I learned so much from this book. I am happy.
- By Jonathan Miller on 09-08-18
By: Rob DeSalle, and others
-
The Deeper Genome
- Why There Is More to the Human Genome than Meets the Eye
- By: John Parrington
- Narrated by: John Lee
- Length: 9 hrs
- Unabridged
-
Overall4 out of 5 stars 106
-
Performance4 out of 5 stars 91
-
Story4 out of 5 stars 92
Over a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way.
-
3 out of 5 stars
-
Great Scientific Writing/ Wrong Narrator
- By Richard on 11-24-15
By: John Parrington
-
Evolving Ourselves
- How Unnatural Selection and Nonrandom Mutation are Changing Life on Earth
- By: Juan Enriquez, Steve Gullans
- Narrated by: Rob Shapiro
- Length: 10 hrs and 50 mins
- Unabridged
-
Overall4.5 out of 5 stars 204
-
Performance4.5 out of 5 stars 178
-
Story4.5 out of 5 stars 181
Why are conditions like autism, asthma, obesity, and allergies exploding at unprecedented rates? Why are we living longer, getting smarter, having far fewer kids? If Darwin were alive today, how would he explain this new world?
-
5 out of 5 stars
-
fascinating ideas and science
- By Joel on 07-04-15
By: Juan Enriquez, and others