Biology Genetics

Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the 20-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics.

In Regenesis, George Church and science writer Ed Regis explore the possibilities of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies - far from the out-of-control nightmare depicted in science fiction - have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span.

Evolutionary theory has long established that humans are animals: Modern Homo sapiens are primates who share an ancestor with monkeys and other great apes. Our genome is 98 percent identical to a chimpanzee's. And yet we think of ourselves as exceptional. Are we? In this original and entertaining tour of life on Earth, Adam Rutherford explores the profound paradox of the "human animal".

Naming Darwin's Black Box to the National Review's list of the 100 most important nonfiction works of the 20th century, George Gilder wrote that it "overthrows Darwin at the end of the 20th century in the same way that quantum theory overthrew Newton at the beginning". Discussing the book in the New Yorker in May 2005, H. Allen Orr said of Behe, "He is the most prominent of the small circle of scientists working on intelligent design, and his arguments are by far the best known."

With rapid advances in genomic technologies, genetic testing has become a key part of both clinical practice and research. Scientists are constantly discovering more about how genetics plays a role in health and disease, and healthcare providers are using this information to more accurately identify their patients' particular medical needs. Genetic information is also increasingly being used for a wide range of non-clinical purposes, such as exploring one's ancestry.

We humans like to think of ourselves as highly evolved creatures. But if we are supposedly evolution's greatest creation, why do we have such bad knees? Why do we catch head colds so often - 200 times more often than a dog does? How come our wrists have so many useless bones? And are we really supposed to swallow and breathe through the same narrow tube? Surely there's been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last.

It seems likely that scientists will someday discover how life can emerge on habitable planets like the early Earth and Mars. In Origin of Life: What Everyone Needs to Know, David W. Deamer has written a comprehensive guide to the origin of life that is organized in three sections.

In this groundbreaking work, evolutionary biologist Jared Diamond stunningly dismantles racially based theories of human history by revealing the environmental factors actually responsible for history's broadest patterns. It is a story that spans 13,000 years of human history, beginning when Stone Age hunter-gatherers constituted the entire human population. Guns, Germs, and Steel is a world history that really is a history of all the world's peoples, a unified narrative of human life.

Australopithecines, dinosaurs, trilobites - such fossils conjure up images of lost worlds filled with vanished organisms. But in the full history of life, ancient animals, even the trilobites, form only the half-billion-year tip of a nearly four-billion-year iceberg. Andrew Knoll explores the deep history of life from its origins on a young planet to the incredible Cambrian explosion, presenting a compelling new explanation for the emergence of biological novelty.

At once a spirited defense of Darwinian explanations of biology and an elegant primer on evolution for the general listener, What Evolution Is poses the questions at the heart of evolutionary theory and considers how our improved understanding of evolution has affected the viewpoints and values of modern man.

Humans are a puzzling species. On the one hand, we struggle to survive on our own in the wild, often failing to overcome even basic challenges, like obtaining food, building shelters, or avoiding predators. On the other hand, human groups have produced ingenious technologies, sophisticated languages, and complex institutions that have permitted us to successfully expand into a vast range of diverse environments. What has enabled us to dominate the globe, more than any other species, while remaining virtually helpless as lone individuals?

In Survival of the Prettiest, Nancy Etcoff, a faculty member at Harvard Medical School and a practicing psychologist at Massachusetts General Hospital, argues that beauty is neither a cultural construction, an invention of the fashion industry, nor a backlash against feminism - it's in our biology.

Everyone has heard of DNA. But by itself, DNA is just an inert blueprint for life. It is the ribosome - an enormous molecular machine made up of a million atoms - that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases.

One of the most famous and influential books of its (or any) time, The Origin of Species is, surprisingly, little read. True enough, most people know what it says, or think they do, at any rate. The first comprehensive statement of the theory of natural selection, it does, indeed, provide the basic argument and demonstration of what we think of as Darwinism.

You are just 10% human. For every one of the cells that make up the vessel that you call your body, there are nine impostor cells hitching a ride. You are not just flesh and blood, muscle and bone, brain and skin, but also bacteria and fungi. Over your lifetime, you will carry the equivalent weight of five African elephants in microbes. You are not an individual but a colony. Until recently, we had thought our microbes hardly mattered, but science is revealing a different story, one in which microbes run our bodies and becoming a healthy human is impossible without them.

From star-nosed moles that have super-sensing snouts to electric eels that paralyze their prey, animals possess unique and extraordinary abilities. In Great Adaptations, Kenneth Catania presents an entertaining and engaging look at some of nature's most remarkable creatures. Telling the story of his biological detective work, Catania sheds light on the mysteries behind the behaviors of tentacled snakes, tiny shrews, zombie-making wasps, and more.

Throughout history, even as daily life has exhibited calm and tolerance, war has never been far away, and even within societies, violence can be a threat. The Goodness Paradox gives a new and powerful argument for how and why this uncanny combination of peacefulness and violence crystallized after our ancestors acquired language in Africa a quarter of a million years ago.

Stepping effortlessly from myth to cutting-edge science, Mutants gives a brilliant narrative account of our genetic code and the captivating people whose bodies have revealed it - a French convent girl who found herself changing sex at puberty; children who, echoing Homer's Cyclops, are born with a single eye in the middle of their foreheads; a village of long-lived Croatian dwarves; one family, whose bodies were entirely covered with hair, was kept at the Burmese royal court for four generations and gave Darwin one of his keenest insights into heredity.

Scientists' understanding of life is progressing more rapidly than at any point in human history, from the extraordinary decoding of DNA to the controversial emergence of biotechnology. Featuring pioneering biologists, geneticists, physicists, and science writers, Life explains just how far we've come - and takes a brilliantly educated guess at where we're heading.

Biogeography is the study of geographic variation in all characteristics of life - ranging from genetic, morphological, and behavioral variation among regional populations of a species, to geographic trends in diversity of entire communities across our planet's surface. From the ancient hunters and gatherers to the earliest naturalists, Charles Darwin, Alfred Russel Wallace, and scientists today, the search for patterns in life has provided insights that proved invaluable for understanding the natural world.