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The Peptide Podcast

The Peptide Podcast

De: The Peptide Queen
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 The Peptide Podcast is on a mission to help people enjoy making decisions about their health and wellness. Staying informed with our SIMPLE, FAST, FUN approach. We keep you up-to-date on everything peptides. From disease management and prevention to performance health, anti-aging strategies, and more. We give you accurate, unbiased information so you can choose the peptides that suit YOU best. In our casual and easy-to-understand style, we’ll help you save time and energy for what matters most. About the host: Our experienced clinical pharmacist, The Peptide Queen, knows all too well that the internet is flawed, confusing, and hard to navigate. She has over 14 years of experience in retail, hospital, and specialty pharmacy, with certifications in peptide therapy, international travel medicine, immunization delivery, and pharmacogenomics. She’s passionate about helping you stay informed, save time, and feel less overwhelmed by the amount of information (or misinformation) on the internet.This website and its content are copyright of The Peptide Podcast - All rights reserved. Any redistribution or reproduction of part or all of the contents in any form is prohibited. Actividad Física, Dietas y Nutrición Ejercicio y Actividad Física Hygiene & Healthy Living Medicina Alternativa y Complementaria
Episodios
  • Breaking Through GLP-1 Weight Loss Plateaus

    Breaking Through GLP-1 Weight Loss Plateaus
    Jun 12 2025
    Welcome to The Peptide Podcast. Today we’re going to talk about something that almost everyone on a GLP-1 journey hits eventually, the weight loss plateau. Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. It starts like this: you begin a GLP-1 like semaglutide or tirzepatide, and for the first few weeks or months, the weight seems to fall off. You’re eating less, not obsessing over food, and for the first time in a long time, it feels… easy. Then one day, the scale just stops moving. You’re not doing anything different. You’re still taking the meds. Still trying to eat well. Maybe you’re walking more or lifting weights. But suddenly, nothing’s happening—and the frustration kicks in. Sound familiar? Let’s talk about what’s really going on. 1. What Causes the Plateau? First of all, if you’re in this place right now: you didn’t mess up. GLP-1s are incredibly effective at reducing appetite and creating an initial calorie deficit, which is why people lose weight so quickly in the beginning. But your body isn’t just going to let that continue unchecked. It adapts. This is called adaptive thermogenesis—a fancy way of saying your body becomes more efficient. You start burning fewer calories at rest than you did before. Your resting metabolic rate actually drops beyond what you'd expect just from losing weight alone. It’s a survival mechanism. So what worked at the beginning—eating less and moving a bit more—might no longer be enough to keep the scale moving. This is totally normal. 2. Metabolism & Muscle: Why Strength Training Matters Now More Than Ever So now that we know why the plateau happens, let’s talk about things we can do to help us get over it. Something that often gets overlooked but is absolutely critical—especially if you’re on a GLP-1 or in any kind of calorie deficit. Resistance training is not optional. It’s non-negotiable. Here’s why. When you’re losing weight—whether it’s from a medication like semaglutide or just eating in a calorie deficit—your body isn’t just pulling energy from fat. If you’re not careful, it’s also going to break down lean muscle tissue. And the more muscle you lose, the slower your metabolism gets. Why? Because muscle is metabolically active tissue. It burns calories even when you’re doing absolutely nothing. So if you’re not actively sending a signal to your body to keep that muscle, it’ll start to let it go. That’s where resistance training comes in. When you lift weights or do bodyweight exercises—think squats, push-ups, resistance bands, even heavy housework—you’re telling your body: “Hey, I need this muscle. Don’t burn it for fuel.” This is especially important for those on GLP-1s because these meds reduce appetite so significantly that you might not be eating enough protein—or enough calories in general—to maintain muscle without that extra stimulus. So if you’ve hit a plateau or want to prevent one, ask yourself: Am I strength training at least two to three times a week? Am I prioritizing movements that challenge large muscle groups—like legs, glutes, chest, and back? Am I fueling my workouts with enough protein? And let me be really clear, you don’t have to become a gym rat. You don’t have to lift crazy heavy weights. But you do have to move your muscles in a meaningful, consistent way. Protecting your lean mass is one of the best ways to keep your metabolism humming—not just during your weight loss journey, but after it too. Because this isn’t about just losing weight—it’s about building a strong, metabolically healthy body that can maintain that weight loss for life. 3. Mindset Check: The Plateau Is Not a Failure Now, let’s get into the mental side of this journey—because it’s just as important as nutrition, movement, and medication. One of the biggest challenges people face—especially when progress slows—is the mental roller coaster that comes with watching the scale. And I’ll be honest: weighing yourself every single day is not ideal. Here’s why. Your body weight naturally fluctuates. Daily. And those fluctuations have nothing to do with your actual fat loss or long-term progress. Instead, the number on the scale is influenced by things like: Hydration status – If you’re slightly dehydrated, the scale may dip. But if you drank a ton of water the day before or had more salty food, it may go up due to water retention. Glycogen stores – When you eat carbs, your body stores them in your muscles and liver as glycogen, and for every gram of glycogen, your body stores about 3–4 grams of water. So a pasta dinner or even a healthy grain bowl can cause a temporary increase on the scale. Digestive contents – Let’s be real: if you haven...
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    12 m
  • Injectable L-Carnitine

    Injectable L-Carnitine
    May 31 2025
    In today’s episode we’ll talk about L-Carnitine. What is L-carnitine, what does it do, and why are more people choosing to inject it instead of taking it as a pill? Let’s break it down. L-carnitine is a compound made from the amino acids lysine and methionine, and its main job is helping your body turn fat into energy by shuttling fatty acids into your cells’ mitochondria. While we naturally make some and get more from foods like red meat and dairy, certain people — like athletes, older adults, or those with metabolic issues — may not make or absorb enough. That’s where supplementation, especially the injectable form, comes in. Why inject L-carnitine instead of taking it by mouth? This is a question I get all the time. Yes, you can take L-carnitine as a pill or powder. But here’s the catch: when you take it orally, your body only absorbs about 15 to 20% of it. That means you'd need to take a whopping 4 to 5 grams daily just to get a therapeutic dose — and that often comes with unpleasant side effects, like bloating, diarrhea, and even that infamous fishy body odor, thanks to a byproduct called trimethylamine. Injectable L-carnitine skips all that. It’s way more bioavailable — so you actually absorb and use what you inject. It’s faster-acting, especially when you give it intramuscularly. And it’s also easier on the gut, since it bypasses digestion and liver metabolism. With the injectable form, you get more targeted results, which is great for things like fat loss, athletic performance, or metabolic health. What are the potential benefits of L-carnitine? Let’s talk about what L-carnitine actually does in your body—because honestly, it’s pretty impressive. First off, it helps you burn fat more efficiently by moving fatty acids into your cells’ mitochondria to be used for energy. It can also boost endurance by delaying fatigue, and it supports faster recovery by reducing soreness and muscle damage after tough workouts. On top of that, it improves blood flow and oxygen delivery to your muscles, which can lead to better pumps and overall performance. It even helps keep fat from building up in organs like your liver and heart, which is great for metabolic health. L-carnitine also plays a role in boosting metabolism and improving insulin sensitivity, especially for those with blood sugar issues. Some studies suggest it can support mental focus and even help with heart function in people with heart conditions. Not bad for a single supplement, right? What about dosing? Injectable L-carnitine doses usually fall between 200 to 1,000 mg per day, though some people aiming for fat loss or performance might go as high as 2,000 mg. Most people split the dose to make injections more comfortable and keep levels steady—like 500 mg in each shoulder, or half in the morning and half before a workout. Timing really does matter, too. It tends to work best first thing in the morning when your body’s ready to burn fat, or about 30 to 60 minutes before training when you need a boost in energy and fat oxidation. Just avoid taking it too late, since it can be pretty stimulating and might mess with your sleep. What are the potential side effects of L-carnitine? Overall, injectable L-carnitine is pretty well tolerated, but like anything, it’s not completely free of side effects. Some people might notice redness or soreness at the injection site, especially if their technique isn’t spot-on. Mild nausea or headaches can pop up too, but they’re usually short-lived and related to the dose. That fishy body odor we talked about earlier? It’s less common with injections than with pills, but it can still happen if your body has trouble breaking down carnitine. Taking it too late in the day might lead to insomnia since it ramps up your energy, and some folks notice an increased appetite—probably because their metabolism is kicking into high gear. And if you’re not staying hydrated or your electrolytes are off, you might get muscle cramps. Who shouldn’t take L-carnitine? L-carnitine can be super helpful for energy and fat metabolism, but it’s not right for everyone. If you have low thyroid function, it might actually make your symptoms worse because it can interfere with how your body uses thyroid hormones. People with a history of seizures should also be cautious, since L-carnitine may increase seizure risk. And while it has some benefits for heart health, there’s some debate about whether it could raise certain byproducts like TMAO that might increase heart disease risk—especially in people who already have heart issues. It can also interact with medications like warfarin, so if you're on a blood thinner, definitely check with your provider. Also, anyone with kidney or liver problems should use it carefully, too, since those organs help process and eliminate it. Oh, and if you’re pregnant, breastfeeding, or prone to insomnia, it’s best to hold off or talk ...
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    6 m
  • Pinealon Peptide Overview

    Pinealon Peptide Overview
    May 22 2025
    Today we’re diving into Pinealon, a bioregulatory peptide with promising effects on brain health, cognition, and aging. We’ll cover what it is, how it works, its benefits, origins, potential side effects, and how to stack it with other peptides like Epitalon. What Are Bioregulator Peptides? Let’s start with the basics. Bioregulator peptides are short chains of amino acids — usually just 2 to 4 — that act as gene switches. Think of them as precision tools your body uses to fine-tune organ and tissue function at the cellular level. These peptides were originally discovered by Russian researchers in the 1970s and 80s as part of their military and space medicine programs. The goal? To help soldiers and cosmonauts stay biologically resilient in extreme conditions. What is Pinealon? Pinealon is a tripeptide made of three amino acids — L-glutamic acid, L-aspartic acid, and L-arginine — and is a synthetic analog of peptides from the pineal gland, which helps regulate sleep-wake cycles and circadian rhythms. Research suggests it may help regulate gene expression in neurons and protect the brain from oxidative stress, a major factor in aging and neurodegeneration. How Does Pinealon Work? So, how does Pinealon actually work? Pinealon appears to cross the blood-brain barrier and interact with the central nervous system, where it may influence gene expression, support neuronal metabolism, reduce oxidative stress, and promote cellular repair — key functions for protecting the aging brain. Potential Benefits of Pinealon So what can Pinealon do for you? Improves cognitive function and mental clarity Helps regulate sleep patterns Reduces oxidative stress in brain cells Supports a calm and balanced nervous system May slow age-related brain degeneration Enhances focus and potentially mood regulation Most of the research has been done in animal models and older humans, but the results so far are promising. Where Are The Potential Side Effects of Pinealon? Now that we’ve covered what Pinealon is and its potential benefits, let’s talk safety. While studies so far show a strong safety profile with minimal side effects at low doses, research is still limited outside of Russia and Eastern Europe. So, if you're considering it, medical guidance is strongly recommended and use only trusted vendors or clinicians when sourcing Pinealon. Potential side effects, while rare, might include: Mild headache Temporary fatigue Sleep disturbances (especially if dosed at the wrong time) This brings me to my next point. When it comes to actually getting your hands on Pinealon, it’s a bit of a challenge. It is available in oral capsule form, but those are pretty hard to find, and there’s not a lot of transparency around who’s making them or how well they’re absorbed. There are also a few online peptide sources that offer Pinealon as an injectable, but again, sourcing is tricky. I’ve personally yet to find a verified, reputable supplier that I’d feel 100% confident recommending. Until there's better regulation or more mainstream availability, it's one of those compounds where you really need to proceed with caution. Peptide Stacks Okay, so we’ve explored what Pinealon does on its own — but what about combining it with other peptides? This is where things get interesting. Peptide stacking is becoming more popular, especially for those looking to optimize cognitive function, longevity, or recovery. So let’s talk about how Pinealon might work in synergy with other peptides. One of the most common stacks involves combining Pinealon with another well-known peptide: Epitalon. Epitalon is also derived from the pineal gland and is known for its anti-aging effects. It helps regulate melatonin secretion, lengthens telomeres, and boosts antioxidant defenses. Together, Pinealon and Epitalon form a neuroendocrine-immune stack that may: Enhance longevity Sharpen cognition Normalize sleep Support mood and stress resilience Other possible stacks: Pinealon + Cerebrolysin – for neuroregeneration Pinealon + Semax – for focus and anxiety Pinealon + Thymalin – for immune and systemic anti-aging The most common Pinealon dosing protocol involves injecting 2mg per day for 10 days, followed by a rest period. This cycle can be repeated 2 to 3 times per year, which means you’re using Pinealon for a total of about 30 days annually. But keep in mind that there’s no universally accepted dosage protocol for Pinealon. Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. Have a happy, healthy week!
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    5 m
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