Original Air Date: April 10, 2008

In this powerful and deeply personal episode, we hear from David Sheff, author of Beautiful Boy, as he shares the harrowing journey of watching his son descend into drug addiction—methamphetamines, heroin, cocaine, and more. His son, Nic Sheff, author of Tweak, offers his own raw account from the other side of addiction, giving voice to the pain, chaos, and complexity of substance dependency.

Together, their stories offer a rare and honest look at how addiction impacts not just the individual, but the entire family. Other families also open up, revealing the devastation and heartbreak that drug dependency can bring—and the hope that healing is possible.

From April 3, 1998: Oprah talks to people who have survived terrible tragedies. Dr. Paul Stoltz, keynote speaker and #1 New York Times best-selling author of The Adversity Quotient discusses how to turn obstacles into opportunities and how adversity leads to strength. Dr. Stoltz also explains what he calls the “constructive blame zone.” Holocaust survivor, psychologist and author Dr. Edith Eva Eger shares her traumatic experiences at the Auschwitz Birkenau concentration camp and explains how to overcome anything through the power of your mind.

From September 11, 1996: Oprah and Bob Greene, exercise physiologist and personal trainer, discuss their No. 1 New York Times best seller, Make the Connection, a book that outlines 10 steps to change your life, lose weight and keep it off. Oprah shares insights from her own weight loss journey, including how to gain discipline and will power, and why it’s important to care about yourself daily. She also talks to people who have successfully lost weight.