What if we could predict diseases before they happen? For Maria Dunford, this isn't science fiction – it's the mission driving her pioneering company LifeBit.

In this captivating conversation with Méline, Maria built the world's largest provider of clinical and DNA data, accessing 270 million patients worldwide. Sparked by her grandfather's cancer diagnosis, she's revolutionising healthcare by shifting from treating symptoms to preventing disease through data.

From newborn genome sequencing screening for 430 diseases to digital twins predicting health trajectories, Maria challenges our understanding of ageing as potentially controlled by resettable molecular clocks. LifeBit's breakthrough? Securely connecting sensitive health data across organisations while keeping individuals in control.

In this enlightening episode, discover:

How birth-to-death data collection could prevent disease before symptoms appear
Why ageing might be a reversible "molecular clock"
How autophagy holds the key to living longer, healthier lives
Why LifeBit's 270 million patient datasets are transforming medicine
Subscribe to The HumanWare Project to join us exploring the frontier where human potential meets cutting-edge technology.

*This content is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional before making any health or lifestyle changes.*

"There are two important days in your life – the day you were born and the day that you found out why."

What drives some of the world's most successful entrepreneurs? For Peter Diamandis – the celebrated founder of XPRIZE, Singularity University and Fountain Life – it's discovering your "Massive Transformative Purpose" (MTP).

In this thought-provoking conversation with Méline, Peter reveals:

• Why only a third of the brightest students at Singularity University knew their purpose in life
• How his purposefinder.ai helps people discover what truly drives them through a series of powerful questions
• Why our medical system trains doctors who follow established patterns rather than staying at the cutting edge
• The science behind biological age – and how it can be reversed through targeted lifestyle interventions
• His approach to longevity through Fountain Life, where he measures and optimises over 200 biomarkers
• The secret to entrepreneurial success: "The world's biggest problems are the world's biggest business opportunities

Peter shares his own journey through multiple MTPs – from opening space commercially to helping entrepreneurs impact a billion people, and now extending the human healthspan. He offers practical wisdom on finding the purpose that will wake you up in the morning and sustain you through challenges.

As Peter puts it: "I truly believe everybody was born to do one special thing only they are born for – but it takes a lot of courage, trial and failure to find it."

**This content is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional before making any health or lifestyle changes.**

What if everything you've been told about healthcare is fundamentally incomplete? While conventional medicine excels at treating disease, in this episode Dr. E reveals why it's shockingly ill-equipped to help you truly thrive. "Industrialised healthcare is like Ford industrialised the manufacturing of cars," he explains. "We have a heart doctor, but you can't speak to them about your stomach problem. It doesn't make sense, right? Because you're one human body."

In this riveting conversation with Méline Liu, Dr. E - a London-trained general practitioner, TEDx speaker, and visionary behind one of London's premier longevity clinics - unveils his revolutionary framework for understanding human health. He reveals how treating the body as disconnected parts is failing us all, while sharing the four fundamental pillars of health that conventional medicine overlooks.

Dr. E explains how the earliest signs of deterioration - subtle changes in energy, mood, digestion - are systematically ignored until they manifest as diagnosable disease. "The HumanWare deteriorates over time," he warns. "The sooner we can identify the deterioration, the quicker we can prevent that deterioration."

Through fascinating insights into cutting-edge therapies, Dr. E shares how his clinic is achieving what many would consider impossible: "I was really surprised that we could improve people's health and their requirement for medication would decrease." From hyperbaric oxygen chambers that stimulate stem cell production to revolutionary treatments that can "reverse a decade of decline in just two weeks," his approach bridges the gap between conventional medicine and optimal human performance.

And what exactly are the four pillars of health as he sees them?

Listen in to find out that what makes Dr. E's perspective so valuable is his ability to bridge conventional medicine with cutting-edge science. Whether you're dealing with persistent health issues or simply want to understand how to maintain optimal performance as you age, this conversation offers practical wisdom for taking control of your health in ways conventional medicine rarely addresses.

As Dr. E eloquently puts it: "Our state now is determined by how we've lived, and our state in the future is how we live now. Big energy equals big bank."

**This content is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional before making any health or lifestyle changes.**

"It might sound corny, but I think this technology will change the world. Imagine how much of our life is dictated by how our brain works and how we've been conditioned by the past. This will help us break free." – James Croall

What happens when a successful Silicon Valley cybersecurity expert keeps falling asleep in executive meetings and struggles to focus? For James Croall, this frustrating reality led to a profound discovery that would completely transform not only his own life but also his entire career trajectory.

In this eye-opening next episode of The Humanware Project, Méline sits down with James Croall, a self-described "neurohacker" who spent 25 years in cybersecurity before pivoting to help others optimise their brain function. Through his own journey overcoming attention deficits and sleep disorders, James discovered that we aren't limited by the brains we think we have – they can be trained, conditioned, and fundamentally rewired.

James reveals the fascinating science behind neurofeedback and neurostimulation, explaining how techniques like transcranial direct current stimulation (tDCS), photobiomodulation, and PEMF therapy can create lasting changes in brain function. As he puts it, "We're trying to understand the language of the brain and then hack it." The results can be remarkable – from clients who go from completing 20% of their to-do lists to 80%, to those overcoming anxiety patterns that had previously paralysed their careers.

Perhaps most compelling is James's breakdown of how our modern environment has rewired many of our brains for distraction. Social media, constant notifications, and multitasking have disrupted our dopamine reward circuitry, leading to attention difficulties even in those without genetic predispositions. Through the neurotherapy techniques James employs, we can potentially reverse these patterns and reclaim our capacity for sustained focus.

What sets this conversation apart is James's unique perspective as someone who approaches the brain like a computer system – identifying patterns, applying the right inputs, and measuring outputs. His background in programming and cybersecurity gives him a distinct advantage in understanding the "language" of the brain and how to hack it for optimal performance.

In this wide-ranging conversation, you'll discover:

- How neurofeedback acts like a "mirror" for your brain, allowing it to see and correct its own patterns
- Why neurostimulation can create faster, more effortless changes in brain function
- The surprising connection between sleep quality and attention span
How vagus nerve stimulation can help balance your autonomic nervous system
- Why ADHD may actually confer certain creative advantages when properly managed
- The ethical considerations around "neurohacking" and finding qualified practitioners
- Through James's eyes, we glimpse a future where technologies like these could fundamentally change how we approach mental health, cognitive performance, and human potential – not by medicating symptoms away, but by teaching our brains to function more optimally from the inside out.

"I've seen people that train twice a day because they believed that was the right thing to do. Yet they were able to achieve better results by actually doing less." - Aaron Deere

The fitness industry thrives on extremes - train harder, eat cleaner, track everything. But what if the secret to optimal health isn't found in pushing limits but in precision? In this episode of The HumanWare Project, Méline sits down with Aaron Deere, Hooke's leading fitness and nutrition expert, who dismantles popular health myths with data-driven clarity.

Aaron, whose journey began as a basketball player before evolving into strength conditioning and nutrition, reveals how the current information overload often leads to confusion and misguided health choices. Drawing from his extensive experience working with athletes, actors, and now longevity-focused clients, he challenges common misconceptions about exercise frequency, nutrition plans, and the latest health technologies.

The conversation takes a fascinating turn as Aaron breaks down Hooke's comprehensive approach to health optimisation. Unlike generic fitness advice found online, their method begins with extensive testing – from cardiovascular fitness to strength assessments – before creating truly customised programs. As Aaron explains, "The key bit is personalisation because you might see something where somebody is giving generic information that might have worked for them or they believe works, but that doesn't mean that it's going to work for you."

Aaron offers valuable insights on several trending health topics, including:

- Why continuous glucose monitors are often misused and how they should instead track patterns rather than vilify specific foods
- The nuanced truth about medications like Ozempic and semaglutide for weight management
- How resistance training becomes even more crucial when using these medications
- The delicate balance between pushing yourself physically and proper recovery
- The four major diseases that comprehensive nutrition plans should aim to prevent

Working alongside Hooke's cognitive health team, Aaron addresses the challenging reality that most lifestyle changes require more than just willpower – they demand systematic approaches to breaking decades-old habits. For listeners struggling to maintain consistency in their health journey, he offers this simple yet powerful reminder: the most effective approach isn't found in New Year's resolutions or extreme regimens, but rather in sustainable practices maintained over time. Listen in to find out the 'one' word that's more important to fitness than any other.

This episode provides a rare glimpse into how elite health optimisation centres like Hooke approach holistic wellbeing, combining cutting-edge testing with personalised interventions and behavioural support to achieve lasting results.

"The ageing phenomenon itself is a kind of inflammatory syndrome... so much cutting-edge research is trying to minimise the impact of that inflammatory change." – Professor Bouloux

What if understanding your brain's electrical activity could unlock the secrets to how you age? In our latest episode, Méline explores the frontier of brain health with Professor Bouloux, senior physician at Hooke and leading endocrinologist.

Professor Bouloux reveals how our brains communicate with our bodies through two crucial pathways – electrical signals via the nervous system and chemical messengers through hormones. This bidirectional communication influences everything from mood fluctuations to the ageing process itself.

The conversation challenges widely-held beliefs about hormonal influences. Women experiencing premenstrual symptoms aren't producing different hormones – they have different responses to them. This individual susceptibility explains why universal health approaches often fall short.

Using Méline's brain scan results, Professor Bouloux demonstrates how measuring brain voltage can provide early warning signs of cognitive issues and establish a baseline for tracking brain health over time.

While cutting-edge experimental treatments exist, Professor Bouloux emphasises the timeless fundamentals: "Lead a really healthy lifestyle, sleep well, be happy, have good nutrition, exercise... and be able to cope with stress." These elements, combined with understanding your unique biology, remain the true "secrets and ingredients" for extending both healthspan and lifespan.

Listen in to understand how your brain-body connection could be the key to living not just longer, but better.

"Whilst chronological age is fixed, biological age can be changed and adapted. Knowledge is power." – Dr. Clare Nieland

What if we could fundamentally transform our approach to ageing, moving from treating illness to preventing it entirely? In this eye-opening episode of The HumanWare Project, Méline sits down with Dr. Clare Nieland, a pioneering longevity physician who splits her time between the NHS and Hooke – one of London's premier longevity clinics.

Dr. Nieland reveals how our traditional healthcare system was never designed for prevention, while explaining how modern science now allows us to measure – and improve – our biological age. By testing over 200 biomarkers – from cardiovascular health to cognitive function – Hooke's approach provides a comprehensive picture of how well you're actually ageing.

The most powerful revelation? While chronological age is fixed, biological age is surprisingly fluid. Through small, sustainable lifestyle changes, we can literally turn back our body's clock. As Dr. Nieland explains, "If you know your numbers, you can introduce small changes that are sustainable, that can then mean those numbers are on an improving trajectory."

This isn't about radical interventions or unattainable regimens. It's about understanding your body's unique needs and making targeted adjustments – whether that's increasing omega-3 intake, improving sleep habits, or finding social connections that give your life meaning and purpose.

Perhaps most importantly, Dr. Nieland challenges our cultural perceptions about ageing itself. Looking at centenarians in the world's Blue Zones, she highlights how many older adults continue living vibrant, meaningful lives well into their 80s, 90s, and beyond.

For listeners of any age, this conversation offers practical wisdom on taking ownership of your health journey. Whether you're in your 20s establishing foundational habits, or later in life seeking optimisation, Dr. Nieland provides actionable insights on how small, consistent changes can yield remarkable long-term results.

In this episode you'll discover why the future of healthcare isn't about treating disease – it's about preventing it entirely through personalised, data-driven approaches that empower you to live your healthiest life at any age.

What if you could predict health problems before they happen? In this eye-opening episode of The HumanWare Project, Méline Liu takes us inside HOOKE – one of London's premier longevity clinics where the focus isn't just on extending life, but optimising it.

Join Méline as she undergoes a series of cutting-edge assessments that go far beyond standard check-ups:

- A brain scan that measures electrical activity and cognitive function
- Analysis of over 200 biomarkers to determine her true "biological age"
- Physical performance tests revealing hidden strengths and weaknesses

Through conversations with HOOKE’S top experts including Dr. Clare Nieland, Professor Pierre-Marc Bouloux and Aaron Deere, Méline uncovers the fascinating science behind preventative healthcare and how small lifestyle changes can dramatically alter your ageing trajectory.

The most powerful revelation? While your chronological age is fixed, your biological age is surprisingly fluid – capable of being improved through targeted interventions based on your unique biomarkers.

This isn't just about living longer – it's about taking ownership of your health, understanding what's actually happening inside your body, and making data-driven decisions that could add years of vitality to your life.

Whether you're a health optimisation enthusiast or simply curious about the future of preventative care, this episode reveals how cutting-edge technology and personalised medicine are transforming our approach to longevity.

As Dr. Nieland says: "Everybody brings to the table their own different experiences... there is no one-size-fits-all when it comes to health."
Discover what your body might be trying to tell you, and why the future of healthcare isn't about treating disease – it's about preventing it entirely.

This is the first of four videos on HOOKE, with the full interviews with Dr Clare Nieland, Professor Pierre-Marc Bouloux and Aaron Deere being released each week.

**This content is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional before making any health or lifestyle changes.**