Dr. James Hill—a expert on obesity, metabolism, and long-term weight management—joins me this week to unpack the biggest challenges in sustainable fat loss. Dr. Hill has spent decades researching weight control and the factors that determine whether people can keep weight off long-term. We discuss the science behind energy balance, metabolic flexibility, and why long-term weight loss is about more than just diet and exercise. He shares insights from his groundbreaking work with the National Weight Control Registry, the role of GLP-1 medications, and why physical activity is the key to preventing weight regain.

We cover:

• The critical differences between weight loss and weight maintenance
• Why physical activity is perhaps more important for keeping weight off than losing it
• The National Weight Control Registry: lessons from long-term weight loss success stories
• How metabolism, muscle mass, and energy expenditure affect weight regain
• The role of protein and resistance training in preserving lean mass
• The impact of GLP-1 medications on weight loss and why most people regain weight after stopping them
• The psychology of weight maintenance: mindset, self-monitoring, and behavior change

If you’ve ever struggled to keep weight off, or you’re interested in the latest research on metabolic health and sustainable weight management, this episode is a must-listen.

Who is Dr. James Hill?

Dr. James Hill is an internationally recognized expert on obesity, metabolism, and weight management. He is the co-founder of the National Weight Control Registry, the largest ongoing study tracking individuals who have successfully lost weight and kept it off long-term. Dr. Hill has published over 400 scientific articles and has led pioneering research on energy balance, metabolic flexibility, and the role of physical activity in weight maintenance. He is a professor at the University of Alabama at Birmingham and has served as the President of The Obesity Society. His work has been instrumental in shaping modern obesity treatment and prevention strategies.

This episode is brought to you by:

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Find Dr. James Hill at:

• International Weight Control Registry https://internationalweightcontrolregistry.org/
• Scholars Profile - https://scholars.uab.edu/6698-james-hill
• Academic Website - https://www.uab.edu/norc/about-us/leadership/executive-committee/james-hill

Find me at:

Instagram: @drgabriellelyon

TikTok: @drgabriellelyon

Facebook: facebook.com/doctorgabriellelyon

YouTube: youtube.com/@DrGabrielleLyon

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In this episode, Dr. Abraham Morgentaler—an expert in urology and hormone health—helps unpack the biggest myths and misconceptions surrounding testosterone therapy for both men and women. He shares his pioneering research on testosterone replacement therapy, challenging outdated fears about its link to prostate cancer and highlighting the latest findings on how hormone therapy can impact overall health, libido, and longevity. The conversation explores the controversial history of testosterone in medicine, the common mismanagement of hormone deficiencies, and why free testosterone may be one of the most important markers for health.

We cover:

• The truth behind the testosterone-prostate cancer debate
• How testosterone deficiency is linked to obesity, cardiovascular disease, and dementia
• The stigma around testosterone therapy and why so many people remain untreated
• The effects of testosterone therapy on fertility, muscle mass, and mental well-being
• The role of testosterone in women's health and aging
• The latest advancements in testosterone treatments and how they compare

Whether you’re considering testosterone therapy, navigating hormone-related issues, or just interested in optimizing your health, this episode offers critical insights that could reshape your understanding of testosterone and its role in overall well-being.

Who is Abraham Morgentaler?

Dr. Abraham Morgentaler is a leading expert in men’s health and a pioneer in the treatment of testosterone deficiency. His research helped overturn the long-held belief that testosterone therapy increases prostate cancer risk, and he has published over 200 scientific articles on testosterone, prostate cancer, and male sexual health. A Harvard-trained urologist, he is currently the Blavatnik Faculty Fellow in Health and Longevity at Harvard Medical School. Dr. Morgentaler is also the founder of Men’s Health Boston and co-founder of the Androgen Society, and he continues to educate clinicians worldwide through his virtual fellowship and best-selling books on men's health.

This episode is brought to you by:

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Find Dr. Morgentaler at:

• T4L Education: https://t4leducation.com/
• Linked In: https://www.linkedin.com/in/abraham-morgentaler-md-81628b6/
• YouTube:

Misinformation in nutrition is rampant. From demonizing red meat to hyping plant-based diets, conflicting advice has left many people confused about what’s truly evidence-based. In this episode, I am joined by Dr. Bradley Johnston, an expert in evidence-based nutrition and public health policies, to separate fact from fiction. With nearly 200 peer-reviewed publications, Dr. Johnston has challenged conventional wisdom—including recommendations from major organizations like the World Health Organization. He shares how evidence-based practices should guide our dietary choices, the importance of systematic reviews and meta-analyses, and how cognitive biases influence the research we trust.

Key Points:

• How evidence-based guidelines are formed—and why they sometimes change
• The three pillars of evidence-based practice and why patient values matter
• Why most nutrition studies aren’t as strong as we think—and how to critically evaluate them
• What the best available research actually says about dietary patterns for longevity
• The role of AI in research and whether it’s a help or hindrance to scientific rigor

If you’ve ever questioned dietary guidelines, nutrition headlines, or conflicting health advice, this episode is a must-listen. Get ready to rethink everything you thought you knew about nutrition.

Who is Dr. Bradley Johnston?

Dr. Bradley Johnston is an Associate Professor at Texas A&M University, specializing in evidence-based nutrition, and the methodology of patient-reported outcomes, randomized clinical trials, systematic reviews, and clinical and public health practice guidelines.

With a PhD in experimental medicine from the University of Alberta and post-doctoral training in evidence-based practice, epidemiology and biostatistics from Oxford and McMaster University, his research focuses on advancing human health research methodology to improve clinical and dietary practice recommendations and public health policies. He co-leads EvidenceBasedNutrition.org and NutriRECS, develops nutrition education resources (e.g. Nutrition Users’ Guides), and currently serves as Co-Chair of the Canadian Pediatric Obesity Management Guidelines, ensuring clinical and public health guidelines are backed and transparently supported by the best available evidence, including end user values and preferences, absolute estimates of effect and the certainty of evidence for estimates of effect. His overall aim is to empower patients, clients and members of the public to make fully-informed health care decisions based on the central tenets of evidence-based practice and policy.

This episode is brought to you by:

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Find Dr. Bradley Johnston at:

• Evidence Based Nutrition - https://www.evidencebasednutrition.org
• Nutrition Users' Guides -https://www.evidencebasednutrition.org/nutrition-user-guides
• Texas A&M University -