In this episode, Dr. JYP welcomes medical oncologist and hematologist Dr. Daisy Escobar to discuss her background and her expertise in cancer diagnosis and treatment. Dr. Escobar shares her journey to the Mitchell Cancer Institute and talks about her family. The conversation focuses on cell-free DNA technology, also known as liquid biopsy, which is used primarily for cancer surveillance and monitoring. Dr. Escobar explains the benefits and limitations of this technology, including how it compares with traditional biopsies and its potential in early cancer detection. The conversation also covers the emotional aspects of cancer surveillance and the importance of patient autonomy in treatment decisions. Dr. Escobar emphasizes the importance of continual research and advancements in cancer diagnostics to improve patient outcomes.

3 Key Listener Takeaways

1. Introduction and implementation of liquid biopsy: Dr. Daisy Escobar explains that liquid biopsy, or cell-free DNA (cfDNA) technology, involves a simple blood draw used primarily to monitor treatment response and detect relapse or recurrence in cancer patients. Unlike traditional biopsies that require tissue samples, liquid biopsy offers a less invasive alternative for surveillance. The ease of monitoring is particularly beneficial for cancer patients who are frequently undergoing lab tests for other reasons. Dr. Escobar details the conditional nature of liquid biopsy’s current use, emphasizing its role in patient monitoring rather than initial cancer diagnosis.

2. Challenges and limitations: Despite its advantages, liquid biopsy is not without its challenges. Dr. Escobar mentions the necessity of comparing ctDNA with DNA from a previous biopsy. Additionally, certain conditions, such as a previous bone marrow transplant, may limit ctDNA effectiveness. Another significant challenge is the potential for emotional impact on patients due to "watchful worrying," knowing that while their markers may be rising, visible signs of cancer may not immediately appear on scans.

3. Potential and future of liquid biopsy: Dr. Escobar discusses the hopeful future of cfDNA technology, particularly for the early detection of ovarian and pancreatic cancers, which currently lack effective screening methods. Advancements in identifying specific ctDNA signatures for various cancers could revolutionize early detection and management, reducing the necessity for more invasive procedures. However, she underscores that while promising, the science has yet to fully catch up to the technology, and ongoing research is crucial.

In this episode, Dr. JYP and State Health Officer Dr. Scott Harris discuss the intersection of infectious disease and cancer in Alabama. Dr. Harris shares insights into the state's cancer trends, including the impact of delayed screenings during the pandemic, and disparities in cancer outcomes based on geography and race. They discuss the collaborative efforts among state agencies, nonprofits, and medical communities to combat cancer. They also delve into Alabama's strategic initiative, Operation Wipe Out, aimed at eliminating cervical cancer through vaccination, screening, and treatment. Additionally, they emphasize the importance of lifestyle changes, regular screenings, and knowing one’s family medical history in preventing cancer. Dr. Harris encourages community involvement and awareness to improve cancer outcomes across Alabama.


3 Key Listener Takeaways


1. Impact of COVID-19 on cancer screenings: Dr. Scott Harris expresses concern over the interruptions in routine cancer screenings due to COVID-19. During the pandemic, many people postponed elective medical procedures, including crucial cancer screenings such as colonoscopies, mammograms, and pap tests. This delay has led to more advanced cancer diagnoses and poorer outcomes.

2. Disparities in cancer outcomes: Dr. Harris highlights significant disparities in cancer outcomes based on geographic location, race, and socioeconomic status. Black residents and those who live in rural areas face a higher risk of developing cancer and dying from the disease. This suggests that social determinants such as access to healthcare, economic opportunity, and education play a significant role in cancer outcomes.

3. Operation Wipe Out and cancer prevention: Operation Wipe Out is a strategic plan to eliminate cervical cancer through vaccination, screening, and timely treatment. The initiative underscores the importance of the HPV vaccine, which can drastically reduce the risk of cervical cancer in women and several other cancers in both men and women. Public health efforts also focus on educating healthcare providers and the public about cancer prevention and available screening programs, particularly in underserved rural areas.

In this heartfelt episode of The Cancering Show, Dr. JYP welcomes back Chaplain Kim Crawford Meeks to discuss the complexities of celebrating the holidays while dealing with cancer. They explore the bittersweet nature of the season, emphasizing the importance of modifying expectations, planning ahead, and cherishing moments with loved ones. Chaplain Kim shares practical advice on managing emotions, supporting family members, and including children in celebrations. They also discuss commemorating a loved one who is no longer present, and ensuring everyone feels valued and included. Whether it's about adjusting holiday plans or creating meaningful memories, this episode offers valuable insights for cancer patients and their families navigating the festive season. Happy holidays from The Cancering Show team.

3 Key Episode Takeaways

Adjust expectations: The holidays may not be the same as they always have been, and that’s OK. Modify your expectations and find new traditions that bring joy.

Plan ahead: Create multiple plans (A, B, C) to accommodate fluctuating energy levels and unexpected changes. This helps to reduce stress and ensures you have fallback options.

Embrace emotions: Allow yourself and your loved ones to feel and express emotions freely. Whether it's sadness, anger, or joy, acknowledging these feelings can lead to more meaningful holiday experiences. Also, don't forget to take photos and videos to capture these precious moments!