When Fred Saad (Urologist, University of Montreal, Montreal) and Andrew Weickhardt (Medical Oncologist, Austin Health, Melbourne) popped into our studio recently we decided to pick their brains on a few hot topics in mHSPC - we called it the ABC of mHSPC! Fred was in Melbourne to visit Peter Mac and do some educational talks and we loved welcoming him back on GU Cast.

A is for ARPIs - who/when/which?
B is for treatment Break - can we use an intermittent approach to ADT/ARPI doublets without yet having trials in the ARPI era to guide us?
C is for Chemo - surely there is almost no role for docetaxel chemo in the ARPI era?? Or so asks Declan, well known triplet therapy sceptic! Do Fred and Andrew agree??!

A great overview of hot topics in mHSCP! Thanks to Fred and Andrew! With your usual hosts Declan Murphy and Renu Eapen.

Even better on our YouTube channel

A big welcome back to EAU Guideline gurus, Dr Derya Tilki (Martini-Klinik, Hamburg, Germany), and Dr Gianluca Giannarini (Santa Maria della Misericordia University Hospital, Udine, Italy), for an overview of the major headlines from this year's EAU Guideline update. Derya is Deputy Chair of the EAU Prostate Cancer Guideline Committee and has picked out four areas to discuss. These are:
1. New stratification for favourable and unfavourable prostate cancer
2. PSMA PET/CT now recommended for unfavourable intermediate-risk cancer
3. No change to PLND recommendations due to lack of benefit in MSKCC RCT update
4. Importance of multidisciplinary approach for mHSPC

So tune in so you can pretend you have read the full 250 page 2025 Guideline!!

Your usual co-hosts are Professor Declan Murphy and Dr Renu Eapen.

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Links:
Updated 2025 EAU Prostate Cancer Guideline

For serious PSMA theranostics enthusiasts!!! We bring you the ninth of our collaborative PSMA webinars over the past five years, in collaboration with our team at ProsTIC and at the Prostate Cancer Foundation in the US. A truly outstanding faculty presenting today including Misha Beltran, Marty Pomper, Ed Kwan and Louise Emmett.

Co-hosted by Declan Murphy and Michael Hofman with a welcome from Howard Soule and Andrea Miyahira. Declan and Michael are joined in studio by Louise Kostos who helps field the many questions from the huge global audience who joined us live.

Much better appreciated on our YouTube channel where you can see all the presentations

What is the da Vinci Single Port (SP) robot and is it any good? Is it easy to transition from the multiport robot to a single port robot? What about Retzius-sparing prostatectomy using the SP robot? GU Cast hosts Declan Murphy and Renu Eapen learn the answers to these questions and more when we visit top prostate cancer surgeons Dr Declan Cahill and Prof Chris Eden at London Bridge Hospital, to see the UK's only SP robot in action. The SP robot has been approved in the US for a few years, and now approved in Europe and Australia, so we hope to have it available for our patients very soon. Plus we see how they use the Neurosafe intra-operative margin assessment technique at London Bridge Hospital.

This one definitely best enjoyed on our YouTube channel

This is a Themed Episode supported by our Partners, Device Technologies.

Like very many countries around the world our friends in China are big fans of the EAU Guidelines, and are always tuned in when the updated Prostate Cancer Guidelines is released every year. So as part of our China Themed Episode Series, supported by our Gold Partners Bayer China, we are discussing some key updates to this year's Guideline with our China Editor Dr Yao Zhu (Shanghai) along with Dr Junlong Zhuang (Nanjing).

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A bit of a break from the usual GU Oncology routine today folks! Declan was back at Guy's Hospital recently doing a talk and heard a remarkable story told by one of the Urology Fellows, Dr Joachim Jimie. A quite spectacular mid-air crisis, and some great life lessons in there also.

Declan could not resist the opportunity to grab Jimie and tell the tale again for GU Cast. Enjoy!!!

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180 episodes later and Declan and Renu have cracked out the champagne in the GU Cast studio! Tune in for this quick pod with some reminiscing and some thank you's, especially to you our global audience!

Radiation cystitis! Now this can be a really challenging condition for urologists, and especially for patients, to manage and to live with. And we frequently struggle to get good results.
It is often years and years after radiation to the pelvis when patients return with problems like bleeding, pain, incontinence, fistula etc, which can have everything from minor, to ruinous effects on quality of life. And although these are radiation oncology patients, it is the urologist (and sometimes other surgeons) who have to manage these unfortunate side-effects of radiation.
Today we travel to London to chat with two Urologists at Guy’s Hospital who have set up a dedicated clinic to manage Radiation Cystitis patients from across the UK. Dr Ramesh Thurairaja and Dr Yasmin Abu Ghanem, explain why they set up this service, and share with us their strategy for assessing and managing radiation cystitis. This episode is full of useful advice for anyone out there managing radiation cystitis, and hopefully might inspire more people to set up similar clinics to look after these unfortunate patients.

Even better on our Youtube channel

Links:
Guy's Hospital Radiation Cystitis Clinic
Pelvic Radiation Disease Best Practice Pathway