Carl Zimmer is one of the finest science communicators of our time, having spent decades writing about biology, evolution, and heredity. His latest (and 16th) book, Air-Borne: The Hidden History of the Life We Breathe, explores something even more fundamental—how the very air around us is teeming with life, from pollen to pathogens to microbes floating miles above the Earth.

He joins Tyler to discuss why it took scientists so long to accept airborne disease transmission and more, including why 19th-century doctors thought hay fever was a neurosis, why it took so long for the WHO and CDC to acknowledge COVID-19 was airborne, whether ultraviolet lamps can save us from the next pandemic, how effective masking is, the best theory on the anthrax mailings, how the U.S. military stunted aerobiology, the chance of extraterrestrial life in our solar system, what Lee Cronin’s “assembly theory” could mean for defining life itself, the use of genetic information to inform decision-making, the strangeness of the Flynn effect, what Carl learned about politics from growing up as the son of a New Jersey congressman, and much more.

Read a full transcript enhanced with helpful links, or watch the full video.

Recorded January 15th, 2025.

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Photo Credit: Mistina Hanscom

How much of your life’s trajectory was set in motion centuries ago? Gregory Clark has spent decades studying social mobility, and his findings suggest that where you land in society is far more predictable than we like to think. Using historical data, surname analysis, and migration patterns, Clark argues that social mobility rates have remained largely unchanged for 300 years—even across radically different political and economic systems.

He and Tyler discuss why we should care about relative mobility vs growing the size of the pie, how physical mobility does and doesn’t matter, why England was a meritocracy by 1700, how assortative mating affects economic and social progress, why India industrialized so late, a new potential explanation why Britain’s economic performance has been lukewarm since WWI, Malthusian societies then and now, whether a “hereditarian” stance favors large-scale redistribution or a free-market approach, the dynamics of assimilation within Europe and the role of negative selection in certain migrations, the challenge of accurately measuring living standards, the neighborhood-versus-family debate over what drives mobility, whether we need datasets larger than humanity itself to decode the genetics of social outcomes, and much more.

Read a full transcript enhanced with helpful links, or watch the full video.

Recorded February 5th, 2025.

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Photo Credit: Chris Williams, Zoeica Images

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For Ross Douthat, phenomena like UFO sightings and the simulation hypothesis don't challenge religious belief—they demonstrate how difficult it is to escape religious questions entirely. His new book, Believe: Why Everyone Should Be Religious makes the case for religious faith in an age of apparent disenchantment.

In his third appearance on Conversations with Tyler, Ross joined Tyler to discuss what getting routed by Christopher Hitchens taught him about religious debate, why the simulation hypothesis resembles ancient Gnostic religion, what Mexican folk Catholicism reveals about spiritual intermediaries, his evolving views on papal authority in the Francis era, what UFO sightings might tell us about supernatural reality, why he's less apocalyptic than Peter Thiel about the Antichrist, and why he's publishing a fantasy novel on Substack before AI potentially transforms creative writing.

Read a full transcript enhanced with helpful links, or watch the full video.

Recorded January 16th, 2025.

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Photo Credit: Abigail Douthat ©