
A Fatal Inheritance
How a Family Misfortune Revealed a Deadly Medical Mystery
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Narrado por:
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Roger Wayne
Acerca de esta escucha
Long-listed, BookPage Best Books of the Year, 2024
National Book Critics Circle Award nominee, 2024
Long-listed, Amazon.com Best Books of the Year, 2024
Long-listed, NPR Best Book of the Year, 2024
"Listeners will find A Fatal Inheritance to be an effective overview of research on cancer and hereditary predisposition, one that achieves serious investigation while remaining intensely human.”—BookPage
Weaving his own moving family story with a sweeping history of cancer research, Lawrence Ingrassia delivers an intimate, gripping tale that sits at the intersection of memoir and medical thriller
Ingrassia lost his mother, two sisters, brother, and nephew to cancer—different cancers developing at different points throughout their lives. And while highly unusual, his family is not the only one to wonder whether their heartbreak is the result of unbelievable bad luck, or if there might be another explanation.
Through meticulous research and riveting storytelling, Ingrassia takes us from the 1960s—when Dr. Frederick Pei Li and Dr. Joseph Fraumeni Jr. first met, not yet knowing that they would help make a groundbreaking discovery that would affect cancer patients for decades to come—to present day, as Ingrassia and countless others continue to unpack and build upon Li and Fraumeni’s initial discoveries, and to understand what this means for their families.
In the face of seemingly unbearable loss, Ingrassia holds onto hope. He urges us to “fight like Charlie,” his nephew who battled cancer his entire life starting with a rare tumor in his cheek at the age of two—and to look toward the future, as gene sequencing, screening protocols, CRISPR gene editing, and other developing technologies may continue to extend lifespans and perhaps, one day, even offer cures.
A Macmillan Audio production from Henry Holt & Company.
©2024 Lawrence Ingrassia (P)2024 Macmillan AudioLos oyentes también disfrutaron...
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“A Fatal Inheritance by Lawrence Ingrassia is a compelling personal chronicle of tragedy and triumph. It captures both the ineffable pain of families riddled with cancers and the remarkable research over the past half century by scientists determined to help them.”—Siddhartha Mukherjee, author of The Emperor of All Maladies: A Biography of Cancer
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- Versión completa
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Historia
A good book may have the power to change the way we see the world, but a great book actually becomes part of our daily consciousness, pervading our thinking to the point that we take it for granted, and we forget how provocative and challenging its ideas once were - and still are. The Structure of Scientific Revolutions is that kind of book.
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The problem is not with the book
- De Marcus en 08-09-09
De: Thomas S. Kuhn
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A Crack in Creation
- Gene Editing and the Unthinkable Power to Control Evolution
- De: Jennifer A. Doudna, Samuel H. Sternberg
- Narrado por: Erin Bennett
- Duración: 9 h y 22 m
- Versión completa
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Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.
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In to the abyss we ascend, a scary future
- De Philomath en 06-17-17
De: Jennifer A. Doudna, y otros
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Cloistered takes the listener deep into the hidden world of a traditional Carmelite monastery as it approaches the third Millennium and tells the story of an intense personal journey into and out of an enclosed life of poverty, chastity, and obedience. Finding an apparently perfect world at Akenside Priory, in Northumberland, Catherine trusts herself to a group of twenty silent women, believing she is trusting herself to God. As the beauty and mystery of an ancient way of life enfold her, she surrenders herself wholly to its power, quite unaware of the complexity and dangers that lie ahead.
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Wise, as much about the failings of all human psychologies as about Catholicism specifically. A timely read.
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In this close-up look at the ardent love affair between the author and her painting teacher, which began in the 1970s, when she was seventeen and he was forty-seven and married with two children, Ciment not only reflects on how their love ignited (who leaned in first for that kiss?) but interrogates her 1990s memoir on the subject, Half a Life. She asks herself if she told the whole truth when she wrote about their passion back then, and what truth looked like to her in the even longer-ago era of love-bead curtains when she fell in love.
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Excellent writing; overworked main question
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Tracing a loose arc from Edwidge Danticat’s childhood to the COVID-19 pandemic and recent events in Haiti, the essays gathered in We’re Alone include personal narrative, reportage, and tributes to mentors and heroes such as Toni Morrison, Paule Marshall, Gabriel García Márquez, and James Baldwin that explore several abiding themes: environmental catastrophe, the traumas of colonialism, motherhood, and the complexities of resilience.
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Always a story to tell
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Grief Is for People is a deeply moving and surprisingly suspenseful portrait of friendship, and a book about loss packed with verve for life. Sloane Crosley is one of our most renowned observers of contemporary behavior, and now the pathos that has been ever present in her trademark wit is on full display. After the pain and confusion of losing her closest friend to suicide, Crosley looks for answers in friends, philosophy, and art, hoping for a framework more useful than the unavoidable stages of grief.
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In this extraordinary work of narrative nonfiction, eight years in the making, sociologists Pamela Prickett and Stefan Timmermans uncover a hidden social world. They follow four individuals in Los Angeles, tracing the twisting, poignant paths that put each at risk of going unclaimed, and introducing us to the scene investigators, notification officers, and crematorium workers who care for them when no one else will.
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Humans are complex, in life and death
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The Friday Afternoon Club
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At nine, Sean Connery saved him from drowning. At thirteen, desperate to hook up with Janis Joplin, he attended his aunt Joan Didion and uncle John Gregory Dunne’s legendary LA launch party for Tom Wolfe’s The Electric Kool-Aid Acid Test. At sixteen, he got kicked out of boarding school, ending his institutional education for good.
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Cloistered takes the listener deep into the hidden world of a traditional Carmelite monastery as it approaches the third Millennium and tells the story of an intense personal journey into and out of an enclosed life of poverty, chastity, and obedience. Finding an apparently perfect world at Akenside Priory, in Northumberland, Catherine trusts herself to a group of twenty silent women, believing she is trusting herself to God. As the beauty and mystery of an ancient way of life enfold her, she surrenders herself wholly to its power, quite unaware of the complexity and dangers that lie ahead.
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Consent
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In this close-up look at the ardent love affair between the author and her painting teacher, which began in the 1970s, when she was seventeen and he was forty-seven and married with two children, Ciment not only reflects on how their love ignited (who leaned in first for that kiss?) but interrogates her 1990s memoir on the subject, Half a Life. She asks herself if she told the whole truth when she wrote about their passion back then, and what truth looked like to her in the even longer-ago era of love-bead curtains when she fell in love.
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Excellent writing; overworked main question
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We're Alone
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Tracing a loose arc from Edwidge Danticat’s childhood to the COVID-19 pandemic and recent events in Haiti, the essays gathered in We’re Alone include personal narrative, reportage, and tributes to mentors and heroes such as Toni Morrison, Paule Marshall, Gabriel García Márquez, and James Baldwin that explore several abiding themes: environmental catastrophe, the traumas of colonialism, motherhood, and the complexities of resilience.
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The Masters of Medicine
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Human history hinges on the battle to confront our most dangerous enemies—the half-dozen diseases responsible for killing almost all of mankind. The story of our medical triumphs reveals an inspiring tapestry of human achievement, but the journey was far from smooth. It is a tale replete with dramatic episodes as spellbinding as any blockbuster Hollywood movie. In The Masters of Medicine, Dr. Andrew Lam, an award-winning author and retinal surgeon, distills the long arc of medical progress down to the crucial moments that were responsible for the world's greatest medical miracles.
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Medical history comes to life
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Sociopath
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Patric Gagne realized she made others uncomfortable before she started kindergarten. Something about her caused people to react in a way she didn’t understand. She suspected it was because she didn’t feel things the way other kids did. Emotions like fear, guilt, and empathy eluded her. For the most part, she felt nothing. And she didn’t like the way that “nothing” felt.
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Fascinating and Perfect Performance!
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My Mama, Cass
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To the rest of the world, Cass Elliot was a rock star; A charismatic, wisecracking singer from the Rock & Roll Hall of Fame inducted band, The Mamas & The Papas; A legend of Laurel Canyon, decked out in her custom-made Muumuus, glittering designer jewelry, blessed with a powerful, instantly identifiable singing voice which helped define the sound of the 1960s counterculture movement. But to Owen Elliot-Kugell, she was just Mom. In her long-awaited memoir, Owen Elliot-Kugell shares the groundbreaking story of her mom as only a daughter can tell it.
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Beautifully written
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Rosalind Brown's Practice shows us just one day. Annabel, sitting in her small student room, attempts to write an essay about Shakespeare. She follows a meticulous, solitary routine but finds it repeatedly thrown off course as the day progresses: by family and friends who demand her attention and time, by thoughts of her much older boyfriend and his impending visit, by wild sexual fantasies and stories of her own invented characters—and by darker crises, obliquely glimpsed but capable of derailing Annabel's carefully laid plans.
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Talented author; book won’t be for everyone
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At the height of the Civil Rights movement, Lydia Abarca was a Black prima ballerina with a major international dance company—the Dance Theatre of Harlem, a troupe of women and men who became each other’s chosen family. She performed in some of ballet’s most iconic works with other trailblazing ballerinas, including the young women who became her closest friends—founding Dance Theatre of Harlem members Gayle McKinney-Griffith and Sheila Rohan, as well as first-generation dancers Karlya Shelton and Marcia Sells. The Swans of Harlem is a riveting account of these five accomplished women.
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Amazing story resilience and creativity
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No One Gets to Fall Apart
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On a highway in Houston, Texas, Sarah LaBrie’s mother was found screaming at passing cars, terrified she would be murdered by invisible assailants. The diagnosis of schizophrenia that followed compelled Sarah to rethink her childhood, marked at turns by violence and all-consuming closeness. Digging into the events that led to her mother’s break, Sarah traces her family history of mental illness, from the dysphoria that plagued her great-grandmother, a granddaughter of slaves, to her own experience with depression as a scholarship student at Brown.
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The prompt seemed simple: Race. Your Story. Six Words. Please Send. The answers, though, have been challenging and complicated. In the twelve years since award-winning journalist Michele Norris first posed that question, over half a million people have submitted their stories to The Race Card Project inbox. The stories are shocking in their depth and candor, spanning the full spectrum of race, ethnicity, identity, and class. Even at just six words, the micro-essays can pack quite a punch, revealing, fear, pain, triumph, and sometimes humor.
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Excellent in every way
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Sam and Elena dream of another life. On the island off the coast of Washington where they were born and raised, they and their mother struggle to survive. Sam works on the ferry that delivers wealthy mainlanders to their vacation homes while Elena bartends at the local golf club, but even together they can’t earn enough to get by, stirring their frustration about the limits that shape their existence.
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Depressing drudgery
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The Hypocrite
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August 2020. Sophia, a young playwright, awaits her father’s verdict on her new show. A famous author whose novels haven’t aged as gracefully into the modern era as he might have hoped, he is completely unaware that the play centers around a vacation the two took years earlier to an island off Sicily, where he dictated to her a new book. Sophia’s play has been met with rave reviews, but her father has studiously avoided reading any of them.
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Consistently boring
- De lifelong learner en 10-09-24
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Hard by a Great Forest
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Historia
Saba is just a child when he flees the fighting in the former Soviet Republic of Georgia with his older brother, Sandro, and father, Irakli, for asylum in England. Two decades later, all three men are struggling to make peace with the past, haunted by the places and people they left behind.
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Evocative and deeply moving
- De 2Rivers en 04-11-24
De: Leo Vardiashvili
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Life After Power
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Historia
Former presidents have an unusual place in American life. King George III believed that George Washington’s departure after two terms made him “the greatest character of the age.” But Alexander Hamilton worried former presidents might “[wander] among the people like ghosts.” They were both right. Life After Power tells the stories of seven former presidents, from the Founding to today. Each changed history. Each offered lessons about how to decide what to do in the next chapter of life.
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Very interesting!
- De MsSew en 11-11-24
De: Jared Cohen
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Knife
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General
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On the morning of August 12, 2022, Salman Rushdie was standing onstage at the Chautauqua Institution, preparing to give a lecture on the importance of keeping writers safe from harm, when a man in black—black clothes, black mask—rushed down the aisle toward him, wielding a knife. His first thought: So it’s you. Here you are. What followed was a horrific act of violence that shook the literary world and beyond.
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Triumph of Life
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De: Salman Rushdie
Lo que los oyentes dicen sobre A Fatal Inheritance
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Historia
- Penelope
- 01-28-25
Fascinating medical nonfiction
Beautifully told story of families suffering from an inherited medical disorder and the researchers looking for the cause. The author uses the story of his own extended family and of several others to make this an unusually poignant and affecting book. The writing is outstanding and the narration is perfect.
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- Avid reader
- 05-17-24
Powerful story told incredibly well
Cancer decimated the author's family, taking lives way too soon, way too often, as he recounts in this book. But this story is much bigger than that. It's an incredibly powerful tale, not just of his family, but of other families, of posing questions and seeking answers. The lyrical prose of his retelling reads like a novel, while his decades as a journalist with the Wall Street Journal, the New York Times, and the Los Angeles Times come through in his detailed chronicling of the journey to unwrap the medical mystery of why his branch of the family (and so many other families) have been plagued by cancer. He skillfully distills medical research into everyday language so that readers can understand the science, while he pieces in families' stories so that they can empathize with the real-life toll cancer takes on so many.
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- Patricia Elizondo
- 07-05-24
Touching story with powerful lessons in hope.
This book provides an overview of the history of cancer diagnosis and treatments in a thoughtful way that is accessible to the non-scientific community. It sets the story context in the lives of cancer patients and their families. If you have a loved one who experienced cancer, you will cry painful tears and hopeful ones. I had to take breaks from the book, and each time it was easy to pick it back up. 🫶
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- Charlene
- 09-27-24
Absolutely beautifully written, fascinating, poignant, tragic and unforgettable.
I am an oncology nurse practitioner and the nerd in me adores a good biomedical documentary. This is more than that, it is an odyssey, and from the moment I started it, I could not put it down. The writing is also at a level that is understandable for people without backgrounds in science, nursing or medicine.
The history of the discovery of this particularly brutal heritable cancer syndrome is absolutely fascinating and Lawrence Engrassia skillfully weaves this together with stories from the initial families studied to ascertain the cause of the syndrome with stories of his own family. The details of these families repeated suffering as family member after family member is torn from them will forever be indelibly seared into my memory.
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- Lisa Ingrassia
- 06-07-24
Stunning story and great reporting
Beautifully reported book, wonderfully read by the narrator. The book intertwines the authors story of losing his entire family to cancer with the story of the epidemiologists who discovered a cancer gene, and the families they studied on their path. This book will be interesting to anyone who has lost a family member to cancer and grappled with fear and grief around that loss.
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- Mildred
- 01-08-25
The research
The personal facts of these families was so honest. The cancer research into the causes of cancer was very talented.
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- patricia Caballero Rodriguez
- 01-15-25
Full of emotion
Honest and straightforward prose , full of emotion. I felt the story and learned so much as well . Worth enduring the technical parts , overall enjoyed .
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- Katherine
- 05-20-24
An important book
This book blends the heart wrenching story of the Ingrassia family and how cancer shadowed three generations with chronicling the discovery of a genetic link. Superb story telling that keeps the reader engaged even as we can anticipate the devastating outcome. The science is conveyed clearly, so that non-scientists can grasp the progress to discovering the key mutation. Engrossing, illuminating and personal.
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- Linda Thompson
- 06-02-24
An Elucidating Memoir
Mr. Ingrassia has managed to write a reader friendly treatise on cancer research that reads like a novel. With a journalist’s talent for getting to the heart of a story in a clear and concise manner, he educates the reader on the process of medical research all the while interspersing the technical issues with the very touching human stories of families, including his own, plagued by recurring cancers. This memoir is truly a masterpiece of research by the author as well as a love letter to his family.
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- mmk
- 06-05-24
Fascinating history, heartbreaking story
I am affected by an inherited genetic mutation with increased cancer risk, and an advocate for expanded germline genetic testing for more people, I feel like I am pretty knowledgeable about the topic but I did not know the backstory and history of the way researchers worked to discover and demonstrate the cancer-genetic link. It was very interesting and told in a way that was technical yet understandable - and interesting! The author wove this background history into the devastating losses in his own family that came, one after another, just a bit too early in time for the discoveries of the genetic link to be beneficial for them. I listened to this audiobook twice to absorb it all. I rarely leave reviews, but this one touched me. I hope it is read widely and that even one family will take a closer look at their family experience with cancer and inquire about germline testing - it could save the lives of the current and next generations.
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